Hematology
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Hematology Basics: Blood Compon... Hematology: Blood Physiology, Co... BIOL 210 Lecture Exam 2 Heredi
27 terms 58 terms 94 terms 62 terms
taylorfoster33 Preview jjbloemker4 Preview Dillonkeithley7 Preview cier
Terms in this set (27) Hide definitions
Order of Erythropoiesis Proerythroblast
Basophilic erythroblast
Polychromatophylic erythroblast
Orthochromic erythroblast
Reticulocyte
Mature RBC
In erythropoiesis, what stages of the rbc are in the Bone 1 through the blast stage
marrow?
Function of blood Carries oxygen in blood to vital organs
Hemolysis Destruction of red blood cells. Can happen after 120 day lifespan, or internal or
external hemolysis factors
What genetic change is seen most often in cases of t(8;14) Translocation of chromosomes 8 and 14
Burkitt Lymphoma?
, What genetic change is seen in patients with Chronic Deletion of 13q
Lymphocyti leukemia? CLL
What genetic change is seen in patients with follicular Translocation of chromosome 14:18
lymphoma?
What genetic change is seen in patients with Chrmic Translocation of chromosome 9:22
myeloid leukemia CML? and even ALL?
What is seen on a peripheral smear for postsplenectomy Since spleen is removed, the body can filter out these rbcs in circulation:
syndrome? acanthocytes, echinocytes, target cells, spherocytes, shistocytes, howell-jolly
Types of Microcytic anemia IDA, Thalassemia, Sideroblastic, Chronic Inflammation
Types of Normocytic Anemia Hereditary hemolytic, acquired hemolytic, hypoproliferative, acute hemorrhage
Types of Macrocytic anemia Megaloblastic, Non-megaloblastic
Iron Deficiency Anemia (IDA) Causes: GI bleedm nosebleeds, kidney or bladder blood loss, intravascular
hemolysis: TTP, DIC
Symptoms: pale, fatigue, SOB, chest pain, Rapid HR, Craving for Ice/clay, brittle
nail, hair loss, dizziness, cold intolerance
Diagnosed via: low: HGB, HCT, MCV, Ferritin, Serum Iron, iron sat, High:TIBC
PB Smear: small, oval shaped RBCs with pale centers, Severe IDA: WBC low, PLT
high or low
Treatment: Red meat, iron supplements, iv iron, blood transfusion
Different types of Thalassemia Alpha-thalassemia, Beta Thalassemia,
Alpha Thalassemia Cause: Deletion in any # of globin gene on chromosome 16
-Silent carrier (1 alpha gene deleted): αα/α- w/ in neborns small amts of Hb Barts
-Thalassemia Minor (two alpha genes deleted) : (αα/–) or (α-/α-)
-microcytic
Alpha Thalassemia Silent Carrier` (αα/α-)
CBC: Normal
PBS:normocytic rbcs
HbA: Normal
HB Barts: 1-3% at birth
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Students also studied
Flashcard sets Study guides
Hematology Basics: Blood Compon... Hematology: Blood Physiology, Co... BIOL 210 Lecture Exam 2 Heredi
27 terms 58 terms 94 terms 62 terms
taylorfoster33 Preview jjbloemker4 Preview Dillonkeithley7 Preview cier
Terms in this set (27) Hide definitions
Order of Erythropoiesis Proerythroblast
Basophilic erythroblast
Polychromatophylic erythroblast
Orthochromic erythroblast
Reticulocyte
Mature RBC
In erythropoiesis, what stages of the rbc are in the Bone 1 through the blast stage
marrow?
Function of blood Carries oxygen in blood to vital organs
Hemolysis Destruction of red blood cells. Can happen after 120 day lifespan, or internal or
external hemolysis factors
What genetic change is seen most often in cases of t(8;14) Translocation of chromosomes 8 and 14
Burkitt Lymphoma?
, What genetic change is seen in patients with Chronic Deletion of 13q
Lymphocyti leukemia? CLL
What genetic change is seen in patients with follicular Translocation of chromosome 14:18
lymphoma?
What genetic change is seen in patients with Chrmic Translocation of chromosome 9:22
myeloid leukemia CML? and even ALL?
What is seen on a peripheral smear for postsplenectomy Since spleen is removed, the body can filter out these rbcs in circulation:
syndrome? acanthocytes, echinocytes, target cells, spherocytes, shistocytes, howell-jolly
Types of Microcytic anemia IDA, Thalassemia, Sideroblastic, Chronic Inflammation
Types of Normocytic Anemia Hereditary hemolytic, acquired hemolytic, hypoproliferative, acute hemorrhage
Types of Macrocytic anemia Megaloblastic, Non-megaloblastic
Iron Deficiency Anemia (IDA) Causes: GI bleedm nosebleeds, kidney or bladder blood loss, intravascular
hemolysis: TTP, DIC
Symptoms: pale, fatigue, SOB, chest pain, Rapid HR, Craving for Ice/clay, brittle
nail, hair loss, dizziness, cold intolerance
Diagnosed via: low: HGB, HCT, MCV, Ferritin, Serum Iron, iron sat, High:TIBC
PB Smear: small, oval shaped RBCs with pale centers, Severe IDA: WBC low, PLT
high or low
Treatment: Red meat, iron supplements, iv iron, blood transfusion
Different types of Thalassemia Alpha-thalassemia, Beta Thalassemia,
Alpha Thalassemia Cause: Deletion in any # of globin gene on chromosome 16
-Silent carrier (1 alpha gene deleted): αα/α- w/ in neborns small amts of Hb Barts
-Thalassemia Minor (two alpha genes deleted) : (αα/–) or (α-/α-)
-microcytic
Alpha Thalassemia Silent Carrier` (αα/α-)
CBC: Normal
PBS:normocytic rbcs
HbA: Normal
HB Barts: 1-3% at birth
