FINAL ADVANCED PHARMACOLOGY CARE OF
THE FUNDAMENTALS ACTUAL ASSESSMENT
2026 COMPLETE SOLVED QUESTIONS
◉ Proton Pump Inhibitors (PPIs). Answer: A group of drugs whose
main action is a pronounced and long-lasting reduction of gastric
acid production. They are the most potent inhibitors of acid
secretion available today. Include drugs like omepraze, and
pentoprazole
◉ Proton pump inhibitors indications. Answer: Gastric/duodenal
ulcers, GERD, erosive esophagitis, Zollinger-Ellison syndrome.
◉ Proton Pump inhibitors MOA. Answer: IRREVERSIBLY Block
H+/K+ ATPase in Parietal Cells of the Stomach --> block acid
production in parietal cells
◉ Proton Pump Inhibitors adverse effects. Answer: Fractures, PNA,
acid rebound, intestinal infections with C. diff, hypomagnesemia,
diarrhea,
◉ Sucralfate (Carafate) MOA. Answer: forms a *physical barrier*
over an open ulcer
, ◉ Sucralfate (Carafate) drug interactions. Answer: •Decreases the
absorption of tetracycline, phenytoin, fat-soluble vitamins, and some
antibiotics
•Antacids decrease the effects of sucralfate
- take Sucralfate at least 2hrs apart from these other drugs.
◉ H. pylori treatment. Answer: PPI + 2 of the following antibiotics
--Clarithromycin
--Metronidazole
--Amoxicillin
One week treatment: 90% cure rate
◉ Hpylori treatment regimens. Answer: PPI+Clarith+Amox
PPI+Clarith+Metro
PPI/H2+Bismuth+Metro+Tetra if clarithromycin allergy (quadruple
therapy)
10-14 days
◉ Antacids MOA. Answer: Neutralize gastric acid to bring the pH
above 3 and inactivate pepsin
Most preparations not absorbed
THE FUNDAMENTALS ACTUAL ASSESSMENT
2026 COMPLETE SOLVED QUESTIONS
◉ Proton Pump Inhibitors (PPIs). Answer: A group of drugs whose
main action is a pronounced and long-lasting reduction of gastric
acid production. They are the most potent inhibitors of acid
secretion available today. Include drugs like omepraze, and
pentoprazole
◉ Proton pump inhibitors indications. Answer: Gastric/duodenal
ulcers, GERD, erosive esophagitis, Zollinger-Ellison syndrome.
◉ Proton Pump inhibitors MOA. Answer: IRREVERSIBLY Block
H+/K+ ATPase in Parietal Cells of the Stomach --> block acid
production in parietal cells
◉ Proton Pump Inhibitors adverse effects. Answer: Fractures, PNA,
acid rebound, intestinal infections with C. diff, hypomagnesemia,
diarrhea,
◉ Sucralfate (Carafate) MOA. Answer: forms a *physical barrier*
over an open ulcer
, ◉ Sucralfate (Carafate) drug interactions. Answer: •Decreases the
absorption of tetracycline, phenytoin, fat-soluble vitamins, and some
antibiotics
•Antacids decrease the effects of sucralfate
- take Sucralfate at least 2hrs apart from these other drugs.
◉ H. pylori treatment. Answer: PPI + 2 of the following antibiotics
--Clarithromycin
--Metronidazole
--Amoxicillin
One week treatment: 90% cure rate
◉ Hpylori treatment regimens. Answer: PPI+Clarith+Amox
PPI+Clarith+Metro
PPI/H2+Bismuth+Metro+Tetra if clarithromycin allergy (quadruple
therapy)
10-14 days
◉ Antacids MOA. Answer: Neutralize gastric acid to bring the pH
above 3 and inactivate pepsin
Most preparations not absorbed
