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ORTHOPEDIC NURSE CERTIFICATION (ONC) EXAM 2025/2026 – 200+ PRACTICE QUESTIONS & ANSWERS WITH RATIONALES

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Ace your Orthopedic Nurse Certification (ONC) exam on the first try with this complete 200+ question practice test – updated for 2025/2026. Covers every essential topic: fracture management (open vs. closed, complications like compartment syndrome, fat embolism), joint arthroplasty (TKA, THA, shoulder), postoperative care & complications, pain management (multimodal, opioid stewardship, neuropathic pain), pharmacology (bisphosphonates, DOACs, gabapentin), rehabilitation & patient education, special populations (geriatric, pediatric, metabolic bone disease), and professional ethics. Every answer includes a detailed rationale so you understand the why – not just memorization. Perfect for orthopedic nurses, nurse practitioners, and those preparing for ONC certification. Stop stressing and start passing. Buy now and get exam‑ready today!

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Orthopedic Nurse Certification (ONC®) Exam

| 2025/2026 Edition Complete Study Guide

with 100% Verified Questions & Answers |

Covers Anatomy, Fractures, Joint

Replacement, Postoperative Care, Pain

Management, Pharmacology, Rehab & More |

Graded A+ | La

1. A patient sustains a fracture that disrupts the blood supply to

the femoral head. Which artery is most likely injured?

A. Lateral circumflex femoral artery

B. Medial circumflex femoral artery

C. Superior gluteal artery

D. Obturator artery

,Page 2 of 138


Answer: B. Medial circumflex femoral artery

Rationale: The medial circumflex femoral artery supplies the

femoral head and neck. Disruption (e.g., femoral neck fracture) can

lead to avascular necrosis.

2. Which structure in the knee is most commonly injured in a non-

contact pivoting injury?

A. Posterior cruciate ligament (PCL)

B. Medial collateral ligament (MCL)

C. Anterior cruciate ligament (ACL)

D. Lateral collateral ligament (LCL)

Answer: C. Anterior cruciate ligament (ACL)

Rationale: The ACL is commonly torn during sudden deceleration,

pivoting, or hyperextension. It prevents anterior translation of the

tibia on the femur.

3. A patient with a rotator cuff tear would most likely have

weakness in which motion?

,Page 3 of 138


A. Shoulder adduction

B. Shoulder external rotation

C. Shoulder internal rotation

D. Elbow flexion

Answer: B. Shoulder external rotation

Rationale: The infraspinatus and teres minor (external rotators) are

part of the rotator cuff. Tears commonly cause weakness in

external rotation and abduction.

4. Which nerve is at greatest risk during a total hip arthroplasty

via a posterior approach?

A. Femoral nerve

B. Obturator nerve

C. Sciatic nerve

D. Superior gluteal nerve

, Page 4 of 138


Answer: C. Sciatic nerve

Rationale: The posterior approach places the sciatic nerve at risk

due to retraction. Damage can cause foot drop and sensory loss.

5. The primary blood supply to the scaphoid bone enters distally.

A fracture through the proximal pole is at high risk for:

A. Nonunion and avascular necrosis

B. Rapid healing

C. Compartment syndrome

D. Infection

Answer: A. Nonunion and avascular necrosis

Rationale: The scaphoid has a retrograde blood supply from distal

to proximal. A proximal pole fracture disrupts blood flow, leading

to high rates of AVN and nonunion.

6. Which ligament of the knee prevents posterior translation of

the tibia relative to the femur?

A. Anterior cruciate ligament (ACL)

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