UPDATE 2026
Define Pharmacokinetics - AnswersThe impact of the body on drugs. How much of an administered
dose gets to its sites of action.
Four major pharmokinetic processes - AnswersDrug absorption, drug distribution, drug metabolism,
and drug excretion.
Define Pharmacodynamics - AnswersThe impact of drugs on the body. The nature and intensity of the
response to the drug.
Two major areas in which you can apply pharmacologic knowledge. - AnswersPatient care and patient
education.
Seven aspects of drug therapy. - AnswersPre administration assessment, dosage and administration,
evaluating and promoting therapeutic effects, minimizing adverse effects, minimizing adverse
reactions, making "as needed" (PRN) decisions, and managing toxicity.
Pre administration assessment - AnswersThree basic goals: collecting baseline data needed to
evaluate therapeutic and adverse responses, identifying high -risk patients, and assessing the patient's
capacity for self-care.
To help reduce adverse effects, you must know - AnswersThe major adverse effects the drug can
produce, when these reactions are likely to occur, early signs that an adverse reaction is developing,
and interventions that can minimize discomfort and harm.
PRN - Answerspro re nata, a Latin phrase meaning as needed
Nursing process - AnswersADPIE - Assessment, analysis (diagnosis), planning, implementation, and
evaluation.
Complete nursing diagnosis - AnswersA statement of the pt's actual or potential health problem, a
statement of the problem's probable cause or risk factors, and the signs, symptoms, or other evidence
of the problem. Statements are separated by the phrases related to and as evidenced by
Objective of drug therapy - AnswersProduce maximum benefit with minimum harm
Pre administration assessment - AnswersEstablish the baseline data needed to tailor drug therapy to
the individual.
Pre administration assessment goals - AnswersCollection of baseline data needed to evaluate
therapeutic effects, collection of baseline data needed to evaluate adverse effects, identification of
high-risk patients, and assessment of the pt's capacity for self-care.
Containdication - AnswersA preexisting condition that precludes use of a particular drug under all but
the most critical of circumstances.
Precaution - AnswersA preexisting condition that significantly increases the risk of an adverse reaction
to a particular drug, but not to s degree that is life threatening.
Pharmacokinetics - Answers1. Absorption 2. distribution 3. metabolism 4. elimination
"Body affecting drugs"
Absorption - AnswersEnteral route involves the GI system (oral)
Parenteral route = IV, IM
Transdermal = through the skin
Respiratory = droplet, inhalation
Distribution - AnswersAmount of drug in the body divided by the plasma drug concentration.
Factors effecting distribution - AnswersBlood flow, lipid solubility, molecular size of the drug, plasma
proteins (very important)
Volume of distribution - AnswersVd = amount of drug in the body divided by the amount of drug in
the plasma divided by bioavailability.
Bioavailability - AnswersHow much drug makes it into the system. Must account for absorption and
extraction.
Extraction - AnswersHow much of the drugs bioavailability can be used by the body.
**IV route dosing (parenteral) - AnswersGoes directly to the body. Results in 100% bioavailability.
Decreasing first pass effect, decreasing absorption limitations, extractions...
By passes absorption and extraction.
Loading dose - Answers[Peak] concentration X Vd divided by bioavailability
Maintenance dose - Answers[Peak] X Clearance divided by bioavailability
Clearance is affected by - AnswersKidney function