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Advanced Pharmacology Exam 1: The Definitive Study Guide | Core Concepts, Rational Prescribing & PK/PD Mastery

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This guide breaks down complex pharmacologic principles—from pharmacokinetics (PK) and pharmacodynamics (PD) to the rational prescribing process, pharmacogenomics, and Ohio prescribing laws—into clear, digestible sections. It’s tailored for Nurse Practitioner, PA, or PharmD students who need to build a rock-solid foundation. Understand enzyme systems, drug-receptor theory, and legal scopes of practice, not just for the test, but for your entire clinical career. Turn pharmacology from a hurdle into your strength.

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Advanced Pharmacology Exam 1 Final Exam Newest Actual
Exam Preparation With Complete Questions And Correct
Answers With Rationales | Already Graded A+||Brand New
Version!!




Prescription writing: required pt and prescriber info - ANSWERS--
Patient's name and full address
Date of prescription
Prescriber's full name, address, and phone number
Prescriber's DEA # if controlled substance


Prescription writing: required drug info - ANSWERS--Name (don't
abbreviate)
Strength and vehicle
Dosage
Route of administration
Directions (Sig) for taking the med: frequency, timing, details specific
to drug
Amount to be dispensed
Refills

,2|Page


Critical Rx Information? - ANSWERS--DAW vs generic, refill #, dose
form, length of therapy/quantity, pt Ax, date of Rx, route, signature,
DEA #


"Rational" Prescribing Process, WHO - ANSWERS--Choose a rational
treatment
Selection of P-drugs (Personal drugs)
Treating the pt (select, Rx, monitor)
Keeping up-to-date


What are P-drugs? - ANSWERS--P(ersonal) drugs - those that you are
going to prescribe regularly and with which you become familiar


Steps of Rational Prescribing - ANSWERS--Define the pt's problem
Specify the therapeutic objective
Choose Tx
Verify: efficacy, safety, suitability, cost
Start Tx (write a clear Rx)
Educate! Give inform instructions, warnings
Monitor treatment


What is DAW in prescribing? - ANSWERS--Dispense as written


"Rights" of a prescription - ANSWERS--Patient
Medication

,3|Page


Dose
Route
Dose schedule
Does this make sense for this drug, patient, situation?


Pharmacokinetics - ANSWERS--How the body affects a drug


Pharmacodynamics - ANSWERS--How a drug affects the body -
effects that occur at the cellular and systemic levels


Pharmacogenomics - ANSWERS--General study of how one's
individual genetic variation affects drug behavior


Four components of pharmacokinetics - ANSWERS--ADME -
absorption, distribution, metabolism, excretion


Absorption - ANSWERS--How (well) does the body uptake the drug?


Distribution - ANSWERS--Transportation of the drug to the site of
action
How (well) is the drug carried to the site of action?


Elimination - ANSWERS--How (well) is the drug cleared from the
body?

, 4|Page


All types of absorption are affected by... - ANSWERS--Drug properties
(molecular weight, lipid solubility) pKa, drug formulation,
disintegration time, dissolution rate)


Enteral Absorption - GI tract - affected by? (4 things) - ANSWERS--
Blood flow to area of absorption
First pass effect
Cellular membrane permeability (passive vs. active)
GI motility (absence/presence of food in stomach, other drugs)


Parenteral Absorption - affected by? (2 things) - ANSWERS--Blood
flow to area of absorption
Cell membrane permeability (passive vs. active transport)


Bioavailability - ANSWERS--Percentage of a drug that reaches the
systemic circulation
Ex: IV route = 100% bioavailability


First pass effect - ANSWERS--PO drug that is absorbed in the GI tract
and metabolized via liver before reaching systemic circulation


Distribution is dependent upon... (3 things) - ANSWERS--Route of
administration
Blood flow
Solubility of drug (lipid/water)

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Number of pages
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