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MSN 672 Quiz 1Antipsychotics
Questions and Answers Latest 2026
Positive symptoms of schizophrenia Ans: Delusions,
hallucinations, disorganized speech/behavior, catatonia.
Negative symptoms of schizophrenia Ans: Blunted affect,
anhedonia, alogia, avolition, apathy, and social
withdrawal.
Cognitive deficits in schizophrenia Ans: Impaired
memory, attention, language, and executive function.
Mood/affective symptoms of schizophrenia Ans:
Depression, dysphoria, and irritability.
FDA-approved indications for antipsychotics Ans:
Psychosis, schizophrenia, mania, Tourette's,
agitation/hyperactivity in autism, intractable hiccups,
nausea, and anxiety.
First-generation antipsychotics (FGAs) Ans: "Typical" or
"conventional" D2 receptor antagonists with higher EPS
risk.
Second-generation antipsychotics (SGAs) Ans: "Atypical"
drugs that block 5HT2A and D2 receptors; lower EPS but
higher metabolic risks.
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Third-generation antipsychotics Ans: Partial D2 agonists
(e.g., aripiprazole, brexpiprazole, cariprazine) that
stabilize dopamine activity.
D2 receptor occupancy needed for efficacy Ans: ~65% for
symptom control.
D2 occupancy causing EPS Ans: >80%.
What reduces EPS risk? Ans: Shorter D2 receptor binding
time (SGAs) and 5HT2A antagonism.
Effect of 5HT2A receptor binding Ans: Reduces EPS and
increases dopamine in the prefrontal cortex.
Alpha-adrenergic receptor blockade effect Ans:
Vasodilation → orthostatic hypotension, erectile
dysfunction, drowsiness.
Histaminic (H1) blockade effect Ans: Sedation, weight
gain, increased appetite.
Muscarinic (M1) blockade effect Ans: Dry mouth,
constipation, blurred vision, urinary retention, cognitive
blunting.
Why do strong anticholinergics have fewer EPS? Ans:
Dopamine normally inhibits acetylcholine; blocking
dopamine increases ACh, so anticholinergics balance this.
Mesolimbic pathway blockade effect Ans: Reduces
psychosis (positive symptoms).
© 2025 All rights reserved
MSN 672 Quiz 1Antipsychotics
Questions and Answers Latest 2026
Positive symptoms of schizophrenia Ans: Delusions,
hallucinations, disorganized speech/behavior, catatonia.
Negative symptoms of schizophrenia Ans: Blunted affect,
anhedonia, alogia, avolition, apathy, and social
withdrawal.
Cognitive deficits in schizophrenia Ans: Impaired
memory, attention, language, and executive function.
Mood/affective symptoms of schizophrenia Ans:
Depression, dysphoria, and irritability.
FDA-approved indications for antipsychotics Ans:
Psychosis, schizophrenia, mania, Tourette's,
agitation/hyperactivity in autism, intractable hiccups,
nausea, and anxiety.
First-generation antipsychotics (FGAs) Ans: "Typical" or
"conventional" D2 receptor antagonists with higher EPS
risk.
Second-generation antipsychotics (SGAs) Ans: "Atypical"
drugs that block 5HT2A and D2 receptors; lower EPS but
higher metabolic risks.
© 2025 All rights reserved
, 2 | Page
Third-generation antipsychotics Ans: Partial D2 agonists
(e.g., aripiprazole, brexpiprazole, cariprazine) that
stabilize dopamine activity.
D2 receptor occupancy needed for efficacy Ans: ~65% for
symptom control.
D2 occupancy causing EPS Ans: >80%.
What reduces EPS risk? Ans: Shorter D2 receptor binding
time (SGAs) and 5HT2A antagonism.
Effect of 5HT2A receptor binding Ans: Reduces EPS and
increases dopamine in the prefrontal cortex.
Alpha-adrenergic receptor blockade effect Ans:
Vasodilation → orthostatic hypotension, erectile
dysfunction, drowsiness.
Histaminic (H1) blockade effect Ans: Sedation, weight
gain, increased appetite.
Muscarinic (M1) blockade effect Ans: Dry mouth,
constipation, blurred vision, urinary retention, cognitive
blunting.
Why do strong anticholinergics have fewer EPS? Ans:
Dopamine normally inhibits acetylcholine; blocking
dopamine increases ACh, so anticholinergics balance this.
Mesolimbic pathway blockade effect Ans: Reduces
psychosis (positive symptoms).
© 2025 All rights reserved
