CELL CYCLE,ROLE IN CONTROL OF DISEASE
.
MLS501
Seminar
A seminar presented to the department of Medical laboratory Science,Faculty of Basic
Medical Science,College of Medicine,ESUT.
Presented By: AGU BARBARA ADAORA
MATRIC NO:2018030186087
Supervisor:Dr Ogbuagbor
, ABSTRACT
Cell cycle, the ordered sequence of events that occur in a cell in preparation for cell
division .The cell cycle is a four-stage process in which the cell increases in size (gap 1, or
G1, stage), copies
its DNA (synthesis, or S, stage), prepares to divide (gap 2, or G2, stage), and divides (mitosis,
or M, stage). The stages G1, S, and G2 make up interphase, which accounts for the span
between cell divisions. On the basis of the stimulatory and inhibitory messages a cell
receives, it “decides” whether it should enter the cell cycle and divide.Using cell cycle and
Understanding the molecular mechanisms of the regulation of cell cycle is a central issue in
molecular cell biology, due to its fundamental role in the existence of cells. The regulatory
circuits that make decisions on when a cell should divide are very complex and particularly
subtly balanced in eukaryotes, in which the harmony of many different cells in an organism is
essential for life. We can study the phases of cell cycle which can be used in control of
diseases.
INTRODUCTION
All living organisms on Earth are made up of cells, which are the functional unit of life.
Eukaryotic organisms can consist of a single cell (unicellular) or a group of either identical or
different cells (multicellular).
This is made possible by cell division, whereby a single cell divides to form two cells. During
a symmetric cell division, a mother cell produces two daughter cells, while an asymmetric
cell division results in a mother and a daughter cell .
The cell cycle refers to the sequence of events that a cell must go through in order to divide.
These events, which always occur in the same order, define the different stages of the cell
cycle: G1, S, G2, and M. What is fascinating about the cell cycle is its universality, and the
main reason for this is that the genetic information of the cell is encoded by exactly the same
molecular entity with exactly the same structure: the DNA double helix. Since both daughter
cells always inherit their genetic information from their parent cell, the underlying
fundamentals of the cell cycle-DNA replication and chromosome segregation-are shared by
all organisms. This review goes back in time to provide a historical summary of the main
discoveries that led to the current understanding of how cells divide and how cell division is
regulated to remain highly reproducible. (Rustem Uzbekov et al.)2022.
The cell cycle is the series of events that take place in a cell that drives it to divide and
produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the G1,
S, G2, and M phases. The M phase is further divided into prophase, pro-metaphase,
metaphase, anaphase, telophase, and cytokinesis. Cell cycle progression is mediated by
cyclin-dependent kinases (Cdks) and their regulatory cyclin subunits. However, the driving
force of cell cycle progression is growth factor-initiated signaling pathways that controls the
activity of various Cdk-cyclin complexes. Most cellular events, including DNA duplication,
gene transcription, protein translation, and post-translational modification of proteins, occur
in a cell-cycle-dependent manner. (Zhixiang Wang)2022.
.
MLS501
Seminar
A seminar presented to the department of Medical laboratory Science,Faculty of Basic
Medical Science,College of Medicine,ESUT.
Presented By: AGU BARBARA ADAORA
MATRIC NO:2018030186087
Supervisor:Dr Ogbuagbor
, ABSTRACT
Cell cycle, the ordered sequence of events that occur in a cell in preparation for cell
division .The cell cycle is a four-stage process in which the cell increases in size (gap 1, or
G1, stage), copies
its DNA (synthesis, or S, stage), prepares to divide (gap 2, or G2, stage), and divides (mitosis,
or M, stage). The stages G1, S, and G2 make up interphase, which accounts for the span
between cell divisions. On the basis of the stimulatory and inhibitory messages a cell
receives, it “decides” whether it should enter the cell cycle and divide.Using cell cycle and
Understanding the molecular mechanisms of the regulation of cell cycle is a central issue in
molecular cell biology, due to its fundamental role in the existence of cells. The regulatory
circuits that make decisions on when a cell should divide are very complex and particularly
subtly balanced in eukaryotes, in which the harmony of many different cells in an organism is
essential for life. We can study the phases of cell cycle which can be used in control of
diseases.
INTRODUCTION
All living organisms on Earth are made up of cells, which are the functional unit of life.
Eukaryotic organisms can consist of a single cell (unicellular) or a group of either identical or
different cells (multicellular).
This is made possible by cell division, whereby a single cell divides to form two cells. During
a symmetric cell division, a mother cell produces two daughter cells, while an asymmetric
cell division results in a mother and a daughter cell .
The cell cycle refers to the sequence of events that a cell must go through in order to divide.
These events, which always occur in the same order, define the different stages of the cell
cycle: G1, S, G2, and M. What is fascinating about the cell cycle is its universality, and the
main reason for this is that the genetic information of the cell is encoded by exactly the same
molecular entity with exactly the same structure: the DNA double helix. Since both daughter
cells always inherit their genetic information from their parent cell, the underlying
fundamentals of the cell cycle-DNA replication and chromosome segregation-are shared by
all organisms. This review goes back in time to provide a historical summary of the main
discoveries that led to the current understanding of how cells divide and how cell division is
regulated to remain highly reproducible. (Rustem Uzbekov et al.)2022.
The cell cycle is the series of events that take place in a cell that drives it to divide and
produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the G1,
S, G2, and M phases. The M phase is further divided into prophase, pro-metaphase,
metaphase, anaphase, telophase, and cytokinesis. Cell cycle progression is mediated by
cyclin-dependent kinases (Cdks) and their regulatory cyclin subunits. However, the driving
force of cell cycle progression is growth factor-initiated signaling pathways that controls the
activity of various Cdk-cyclin complexes. Most cellular events, including DNA duplication,
gene transcription, protein translation, and post-translational modification of proteins, occur
in a cell-cycle-dependent manner. (Zhixiang Wang)2022.
