Lung Cancer
most common cause mortality worldwide
55
of cancer
age 84
peak b w 65 76
yes
most Ca are I
of lung as
cigarette smoking
Etropathogenesis
Smoking
Tobacco consists of polycyclic hydrocarbons
nitrosamines potent carcinogens
polyclic hydrodcarbon bopyline compoun
bind to nuclear DNA
tumorpromoter
mutations
80
lung cancers in smokers
occur
cessation Isa risk not to baseline
of cancer α
smoking
feeg lung
of pack of cigerate years
women are more susceptible smoking
secondhand smoke Carcinogenic effect to those
who live work I smokers
industrial Hazards
Exposure to Asbestos assent beanium chrome
nickel high doseof ionizing radiation
the risk
of
lung ca
, Air pollution
Chr exposure to pollutants
being tipitation inflammation
repair
Trisk of cancer
adds on in smokers
Acquired mutations
Adenocarcinoma common in nonsmokers
GOF meet in genes encoding receptor TK
EGFR
ACK
ROSI
MET
GOF meet in KRAS BRAF genes
Squamous cell carcinoma
Chr deletions 3p 9p CDK NIA
of gene
17p P53
amplificationof FG FRI
SCC both p53 RB inactivated
3p deletion
Precursor
leftypical adenomatous hyperplasia
12 adenocarcinoma insite
3
Squamous dysplasia CIS
a differe idiopathic pulmonary
neuroendocrine cells hyperplasia
most common cause mortality worldwide
55
of cancer
age 84
peak b w 65 76
yes
most Ca are I
of lung as
cigarette smoking
Etropathogenesis
Smoking
Tobacco consists of polycyclic hydrocarbons
nitrosamines potent carcinogens
polyclic hydrodcarbon bopyline compoun
bind to nuclear DNA
tumorpromoter
mutations
80
lung cancers in smokers
occur
cessation Isa risk not to baseline
of cancer α
smoking
feeg lung
of pack of cigerate years
women are more susceptible smoking
secondhand smoke Carcinogenic effect to those
who live work I smokers
industrial Hazards
Exposure to Asbestos assent beanium chrome
nickel high doseof ionizing radiation
the risk
of
lung ca
, Air pollution
Chr exposure to pollutants
being tipitation inflammation
repair
Trisk of cancer
adds on in smokers
Acquired mutations
Adenocarcinoma common in nonsmokers
GOF meet in genes encoding receptor TK
EGFR
ACK
ROSI
MET
GOF meet in KRAS BRAF genes
Squamous cell carcinoma
Chr deletions 3p 9p CDK NIA
of gene
17p P53
amplificationof FG FRI
SCC both p53 RB inactivated
3p deletion
Precursor
leftypical adenomatous hyperplasia
12 adenocarcinoma insite
3
Squamous dysplasia CIS
a differe idiopathic pulmonary
neuroendocrine cells hyperplasia
