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Obesity Medicine Exam Questions And Answers Graded A+ 2025/2026

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Obesity Medicine Exam Questions And Answers Graded A+ 2025/2026 FTO gene - Fat mass and obesity associated gene region first locus unequivocally associated with adiposity- higher BMI/total weight (chromosome 16 q12.2) Only chromosome that does not show obesity loci? - Y chromosome Most common syndromal cause of obesity? - Prader Willi Syndrome Autosomal dominant 1/25000 Hypotonia, short stature, hyperphagia Prader-Willi Syndrome - Most common syndromal cause of obesity Autosomal dominant 1/25,000 Hypotonia, short stature, hyperphagia Most common obesity syndrome - MC4R syndrome 1/2000 LEP deficiency - Gene: LEP Hypogonadism frequent infections undetectable serum leptin LEPR deficiency - LEPR Gene

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Obesity Medicine Exam Questions And Answers
Graded A+ 2025/2026
FTO gene - Fat mass and obesity associated gene region first locus unequivocally
associated with adiposity- higher BMI/total weight (chromosome 16 q12.2)

Only chromosome that does not show obesity loci? - Y chromosome

Most common syndromal cause of obesity? - Prader Willi Syndrome
Autosomal dominant 1/25000
Hypotonia, short stature, hyperphagia

Prader-Willi Syndrome - Most common syndromal cause of obesity
Autosomal dominant
1/25,000
Hypotonia, short stature, hyperphagia

Most common obesity syndrome - MC4R syndrome
1/2000

LEP deficiency - Gene: LEP
Hypogonadism
frequent infections
undetectable serum leptin

LEPR deficiency - LEPR Gene
Hypogonadism

POMC deficiency - POMC gene
Hypopigmentation
Isolated ACTH deficiency

PCSK1/3 deficiency - PCSK1 gene
Postprandial hypoglycemia
Hypogonadism
Elevated plasma pro insulin
Elevated 32-33 split proinsulin

MC4R deficiency - MC4R gene
Melanocortin 4 receptor
Accelerated growth
Increased final height

BDNf deficiency - BDNF gene
Development delay
Hyperactivity

, Impaired memory
Impaired pain sensation

TrkB deficiency - NTRK2 gene
Development delay
Hyperactivity
Impaired memory
Impaired pain sensation

S1M1 deficiency - S1M1 gene
Spectrum of development delay

BBS deficiency - BBS1-16 gene
Polydactyly
Retinal dystrophy
Hypogonadism
Renal abnormalities
Developmental delay

Alstrom Syndrome - ALMS-1 gene
Photophobia
Nystagmus
Visual impairment
Deafness
Severe insulin resistance
Can have high triglycerides

AHD - GNAS1
Short stature
Skeletal defects
Hormone resistance

Short stature
Skeletal defects
Hormone resistance - AHD deficiency

Photophobia
Nystagmus
Visual impairment
Deafness
Severe insulin resistance - Alstrom syndrome

Polydactyly
Retinal dystrophy
Hypogonadism
Renal abnormalities

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