1. Etiology
• Initiating cause
• Genetic and
Environmental factors
2. Pathogenesis
• Sequence of events
that lead to the
development of the
disease.
• Central focus of
pathology 4 Aspects of a
3. Morphologic Changes Gen
• Structural changes Disease
seen in tissues and System
cells Process
• Pathognomonic signs
or characteristics of a
disease.
4. Clinical Manifestations Rudolf
• Signs and symptoms Virchow
manifested by the Pioneer of pathology
Asserted that diseases
patient based on originated at
etiology, pathogenesis, cellular
level.
and morphologic
changes.
Pathology: Study
functional changes in
• Logos: s
• Pathos: s
General Pathology
• Common reactions of cells and
tissues and how they respond to
injurious stimuli.
Epidermal Growth Factor/ TGF-ą
• Promote mitosis of hepatocytes, fibroblasts, and
other epithelial cells (keratinocytes).
SOURCES: • Stimulates formation of granulation tissue and
• Activated macrophages keratinocyte migration
• Salivary glands • ERB-B1/EGFR1 Mutation: indicative of cancer
• Keratinocytes (lung, head and neck, breast, brain)
• ERB-B2/HER2: Breast cancer (treated with
Herceptin/Trastuzumab)
Transforming Growth Factor/ TGF-ß
SOURCES: • Belongs to a larger family which includes: BMPs, Activins,
• Initiating cause
• Genetic and
Environmental factors
2. Pathogenesis
• Sequence of events
that lead to the
development of the
disease.
• Central focus of
pathology 4 Aspects of a
3. Morphologic Changes Gen
• Structural changes Disease
seen in tissues and System
cells Process
• Pathognomonic signs
or characteristics of a
disease.
4. Clinical Manifestations Rudolf
• Signs and symptoms Virchow
manifested by the Pioneer of pathology
Asserted that diseases
patient based on originated at
etiology, pathogenesis, cellular
level.
and morphologic
changes.
Pathology: Study
functional changes in
• Logos: s
• Pathos: s
General Pathology
• Common reactions of cells and
tissues and how they respond to
injurious stimuli.
Epidermal Growth Factor/ TGF-ą
• Promote mitosis of hepatocytes, fibroblasts, and
other epithelial cells (keratinocytes).
SOURCES: • Stimulates formation of granulation tissue and
• Activated macrophages keratinocyte migration
• Salivary glands • ERB-B1/EGFR1 Mutation: indicative of cancer
• Keratinocytes (lung, head and neck, breast, brain)
• ERB-B2/HER2: Breast cancer (treated with
Herceptin/Trastuzumab)
Transforming Growth Factor/ TGF-ß
SOURCES: • Belongs to a larger family which includes: BMPs, Activins,
