Nucleic acids DrA Primary STRUCTURE
Structure PLaMary
Perose
Sugars
Neroxides Structure Are of Phosphate
PENTOSE And A BASE
composed
Sugor ,
,
RIS
Erig
THE RiBosE
In DIS TE PEMOSE WHEREAS
Simply PROSE WHEN NurB Carbons
M IS
DEOxyPROSE
Sugar
In
Sugar
iS I . ,
a
Sogan Adds 'To from
distinguish
One THEM THE CARBONS In THE BASE
pres
·
H
&
H
THE ATTACHED I' CARBON AND
-
SUGAR
IS MS
TO BASE AI HS TO S
PHOSPHATE
Ho -H Ho -H OH
.I
OH
Il
& · 5
5
2
- Al ITS S'CARBON 5: PO THE 3'-OH LAKED THE 5'-PO of An O
un is To
O
F
-
.
~
21
!I
~
I &
H H
primary H 4
It
4 I
Adjacen Meleotide To form The
Sugar-Phosphate Backbone .
It H H
Ho
C 13
[
· Ho
,
F
··
S. 8O
S3 of H
& > Primary Structure Ether Purme or pyridone
... "The Bases :
um RIBOSE DEOXYROSE
Ia
a
& ↳I- &
·
·
C SW
&
a
7
C5
-
BECAUSE SOME OFTHER
· THEY ARE CALLED BASES BE
NAROGENS
CAN
D
,
·
ARE ALL AROMATR
PROTONATED THEY .
Pure GtA Pyramidme Catar
2
- T · ⑨g
e "
-
· -
I I
Ed
--> Go THE PENTOSE FORMS A BOND
G
P - CONTENT WITH THE
g&
-
2 S8
·
·
.
- s
e 2 N
-C⑧C··
&
-
?g
O
T
--
· I
g)
-&-
- (
N34
- -
.
I 1No
,
D
⑨g
d⑳ &*
Called
B-glycoside Image
S S S Base a
S
·
W
- & C L I
2
- acce
S
S
-v
&
mer
-J 9
~
T -
7
- Nu Premes = Tac tu
-
Pyrmidmes = G +A
NICLEOIDE AOCEOSIDE : MCLEOSUdE BASE PHOSPHONESTER Bot Dra And Rea
LINKAGES
US A THE PHOSPHATE GROOPS ACT TO WNK
Only PHOSPHATE THE
SugarS
US
Sugar group
No : In
,
And PHOSPHATE WHEN S'end has
REFERRNey
A Microde HA BASE , A CLEOXIDE , A Adenosme BACKBONES THIS Bond is Called PhosphodresTER Because The free
Linkage
a
Sugar Group
A , ,
To = .
. a
C=
cytidine
(mgate)
G Gustnosme uridine and The 3 End has free 3-oh The Dread Rea
Phosphate group (neutral)
= U = a
, , .
,
5
8- &
BACKBONES ARE
I Asymmetric POWER
.
-
P O
DO
Parame
And PH (7 4) The
BASE DrABASES Parr A-L Acid AT pHospHATE of
Every necroside
PHOSPHATE
Physiological Group
C-G mit
Group
THE is An . .
,
O
Bonds G-cpars form Bonds
Hydrogen Hydrogen
HOW MOTHER ACROS
MAKING
THIS THER
VEGANE
3 is
DEPROTONATED I NAME
GO
.
IS
BASE
.
,
CH2
Whe A Parks form 2
Hydrogen
Bonds . THE H-Bonds
It H &
I
-H
BETWEEN ANT AND CaG ARE ALL
AppROXIMATEly
14 = DNA
SECONDARY STRUCTURE
S It
01 This MEANS THAT SECONDARY DIA STRANDS RUN
Equal MEASORg
:
, -2 9-3. . .
I
STRUCTURE BASE
STACKING
TWO
COMPLEMENTARY
-
P O
Wit Around form DOUBLE HELIX
SUGAR-PHOSPITALE
THE DISTANCE BETWEEN THE TWO
AnTipARALLEL To ONE ANOTHER & THE SAME Axis To A .
owE
O
BackBONES REMANS CONSTANT FEATURE THAT CONTRIBUTES THE ROTATHEN BASE BASES ARE HydropitoBra
STACKING
TO IS
BASE
CH2
BASE
Specifica
Parking
was first proposed
By Wayson
It H I And HydropHOBiC EFFECTS WORK TO MANIMATE CONTACT WINNER THE .
BASES ARE
sugHLy
Concluded
It H
offset due forces
↓ crick in 1953
By X-Ray DiffRACTron
THEY han der The
PHOSPHE Backbones Are Hydrophic
Sugar
, To WAALs . .
0 It
THAT THE DOUBLE HELICAL STRUCTURE IS POSSIBLE BECAUSE Due offSET of BASES HEL forms a da Maor
major
PARING
THE Dra DOUBLE
Groove
To THE
I ,
-
P O
oppose faces
specific Base of
The duplex
of THE
Complementary of Each THESE The Base
Groves
he
pares
on
graere
Two
paremy
·
.
or .
O
STRAND WHAT THE EXPOSED TO THOSE
S
PERMIS REPLICATION MAJORGROOVE ARE
THAN THE MMOR
SOLEM
MORE
GROTE
ON
BASE
CH2
It H I DNA Secondary Structure Forms of The double Helix : THE form of THE DOUBLE HELN
H HumidMy of THE
DEPENDMY
O ABSORBANCE THE RESOURCE EMPROMEN THE MORE Humid THE EmONMENT
Among
Pure WRRES THE
: On .
,
O It
forms of
The
↓
Pyramide Acids hel handed.
Rigs
ABSorpyow The LOOSER The Dra Rich
Righ
Allows O . NorEic . not All Duplex Are in 1979,
S
H .
3
Extra ABSORBANCE AT J Th discovered Left HandEd HELICAL Dra
260 nm
PROPERTY
strong
= .
.
Stranded
distinguish
Allows us DOUBLE
SAGE
to BILW
This Is known as The A Bi Z
Dra .
HyperChromic Effect
. .
5?
10
.
10 RESidES
. 7 -
F
DOUBLE STRANDED DNA CAN BE SEPARATED W/HEAT .
[
PERTURN .
>
~
10 Resides 12 RESidES
=
-
-
PER TURN
-
-
- PER TURN
handed
F
THE TEMP WHICH Y Of ALL ArnotEd Its HAndEd
Rig
DreA A Lets
Righ
AT in
Sample is
-
-
- F
-
(smgle-stranded) PrcHA
Dematured Tm When The Drea Prch Prch
-
is 33 2 45 6
-
.
= 24 6
. - =
.
= .
-
1
F
-
- -
condem
-
is COOLED, M REANNEAls .
MOST COMMON E
most PH
A Bro
:
-
STACKED BASES ABSORB MORE
LIGH
THAN LISTACKED .
E
-
=
-
-
LEAT CONSENSED
-
Strands
ABSORBANCES
Quenched WHEN reared -
concentBicest
innurousmarit
F
Also BE Devoured read
-
9
By
Removing
DNA CAN wa
ignoi rbackBand
no SALT A-1 Pict frast
Hrg h
t
Regros
. Mele .
saly
Long Sequences
STABME Dut .
Structure PLaMary
Perose
Sugars
Neroxides Structure Are of Phosphate
PENTOSE And A BASE
composed
Sugor ,
,
RIS
Erig
THE RiBosE
In DIS TE PEMOSE WHEREAS
Simply PROSE WHEN NurB Carbons
M IS
DEOxyPROSE
Sugar
In
Sugar
iS I . ,
a
Sogan Adds 'To from
distinguish
One THEM THE CARBONS In THE BASE
pres
·
H
&
H
THE ATTACHED I' CARBON AND
-
SUGAR
IS MS
TO BASE AI HS TO S
PHOSPHATE
Ho -H Ho -H OH
.I
OH
Il
& · 5
5
2
- Al ITS S'CARBON 5: PO THE 3'-OH LAKED THE 5'-PO of An O
un is To
O
F
-
.
~
21
!I
~
I &
H H
primary H 4
It
4 I
Adjacen Meleotide To form The
Sugar-Phosphate Backbone .
It H H
Ho
C 13
[
· Ho
,
F
··
S. 8O
S3 of H
& > Primary Structure Ether Purme or pyridone
... "The Bases :
um RIBOSE DEOXYROSE
Ia
a
& ↳I- &
·
·
C SW
&
a
7
C5
-
BECAUSE SOME OFTHER
· THEY ARE CALLED BASES BE
NAROGENS
CAN
D
,
·
ARE ALL AROMATR
PROTONATED THEY .
Pure GtA Pyramidme Catar
2
- T · ⑨g
e "
-
· -
I I
Ed
--> Go THE PENTOSE FORMS A BOND
G
P - CONTENT WITH THE
g&
-
2 S8
·
·
.
- s
e 2 N
-C⑧C··
&
-
?g
O
T
--
· I
g)
-&-
- (
N34
- -
.
I 1No
,
D
⑨g
d⑳ &*
Called
B-glycoside Image
S S S Base a
S
·
W
- & C L I
2
- acce
S
S
-v
&
mer
-J 9
~
T -
7
- Nu Premes = Tac tu
-
Pyrmidmes = G +A
NICLEOIDE AOCEOSIDE : MCLEOSUdE BASE PHOSPHONESTER Bot Dra And Rea
LINKAGES
US A THE PHOSPHATE GROOPS ACT TO WNK
Only PHOSPHATE THE
SugarS
US
Sugar group
No : In
,
And PHOSPHATE WHEN S'end has
REFERRNey
A Microde HA BASE , A CLEOXIDE , A Adenosme BACKBONES THIS Bond is Called PhosphodresTER Because The free
Linkage
a
Sugar Group
A , ,
To = .
. a
C=
cytidine
(mgate)
G Gustnosme uridine and The 3 End has free 3-oh The Dread Rea
Phosphate group (neutral)
= U = a
, , .
,
5
8- &
BACKBONES ARE
I Asymmetric POWER
.
-
P O
DO
Parame
And PH (7 4) The
BASE DrABASES Parr A-L Acid AT pHospHATE of
Every necroside
PHOSPHATE
Physiological Group
C-G mit
Group
THE is An . .
,
O
Bonds G-cpars form Bonds
Hydrogen Hydrogen
HOW MOTHER ACROS
MAKING
THIS THER
VEGANE
3 is
DEPROTONATED I NAME
GO
.
IS
BASE
.
,
CH2
Whe A Parks form 2
Hydrogen
Bonds . THE H-Bonds
It H &
I
-H
BETWEEN ANT AND CaG ARE ALL
AppROXIMATEly
14 = DNA
SECONDARY STRUCTURE
S It
01 This MEANS THAT SECONDARY DIA STRANDS RUN
Equal MEASORg
:
, -2 9-3. . .
I
STRUCTURE BASE
STACKING
TWO
COMPLEMENTARY
-
P O
Wit Around form DOUBLE HELIX
SUGAR-PHOSPITALE
THE DISTANCE BETWEEN THE TWO
AnTipARALLEL To ONE ANOTHER & THE SAME Axis To A .
owE
O
BackBONES REMANS CONSTANT FEATURE THAT CONTRIBUTES THE ROTATHEN BASE BASES ARE HydropitoBra
STACKING
TO IS
BASE
CH2
BASE
Specifica
Parking
was first proposed
By Wayson
It H I And HydropHOBiC EFFECTS WORK TO MANIMATE CONTACT WINNER THE .
BASES ARE
sugHLy
Concluded
It H
offset due forces
↓ crick in 1953
By X-Ray DiffRACTron
THEY han der The
PHOSPHE Backbones Are Hydrophic
Sugar
, To WAALs . .
0 It
THAT THE DOUBLE HELICAL STRUCTURE IS POSSIBLE BECAUSE Due offSET of BASES HEL forms a da Maor
major
PARING
THE Dra DOUBLE
Groove
To THE
I ,
-
P O
oppose faces
specific Base of
The duplex
of THE
Complementary of Each THESE The Base
Groves
he
pares
on
graere
Two
paremy
·
.
or .
O
STRAND WHAT THE EXPOSED TO THOSE
S
PERMIS REPLICATION MAJORGROOVE ARE
THAN THE MMOR
SOLEM
MORE
GROTE
ON
BASE
CH2
It H I DNA Secondary Structure Forms of The double Helix : THE form of THE DOUBLE HELN
H HumidMy of THE
DEPENDMY
O ABSORBANCE THE RESOURCE EMPROMEN THE MORE Humid THE EmONMENT
Among
Pure WRRES THE
: On .
,
O It
forms of
The
↓
Pyramide Acids hel handed.
Rigs
ABSorpyow The LOOSER The Dra Rich
Righ
Allows O . NorEic . not All Duplex Are in 1979,
S
H .
3
Extra ABSORBANCE AT J Th discovered Left HandEd HELICAL Dra
260 nm
PROPERTY
strong
= .
.
Stranded
distinguish
Allows us DOUBLE
SAGE
to BILW
This Is known as The A Bi Z
Dra .
HyperChromic Effect
. .
5?
10
.
10 RESidES
. 7 -
F
DOUBLE STRANDED DNA CAN BE SEPARATED W/HEAT .
[
PERTURN .
>
~
10 Resides 12 RESidES
=
-
-
PER TURN
-
-
- PER TURN
handed
F
THE TEMP WHICH Y Of ALL ArnotEd Its HAndEd
Rig
DreA A Lets
Righ
AT in
Sample is
-
-
- F
-
(smgle-stranded) PrcHA
Dematured Tm When The Drea Prch Prch
-
is 33 2 45 6
-
.
= 24 6
. - =
.
= .
-
1
F
-
- -
condem
-
is COOLED, M REANNEAls .
MOST COMMON E
most PH
A Bro
:
-
STACKED BASES ABSORB MORE
LIGH
THAN LISTACKED .
E
-
=
-
-
LEAT CONSENSED
-
Strands
ABSORBANCES
Quenched WHEN reared -
concentBicest
innurousmarit
F
Also BE Devoured read
-
9
By
Removing
DNA CAN wa
ignoi rbackBand
no SALT A-1 Pict frast
Hrg h
t
Regros
. Mele .
saly
Long Sequences
STABME Dut .
