*Cytosol
GLYCOLYSIS ppp CHOLESTEROL
PENTOSE PHOSPHATE SYNTHESIS
Glucose
PATHWAY Cholesterol esters
GLYCOGENESIS
PURINE Cell membranes
G-1-P G-6-P Ribulase-6-phosphate Ribose-5-phosphate Steroids
(Irreversible redox stage) SYNTHESIS Cholesterol VIT D
Bile salts
F-6-P
(Reversible interconversion stage)
*Li
SYNTHESIS
Glycogen *RBC & nondividing cells Hypoxanthine ver
*Stored in liver
Lansterol 7-dehydrocholesterol
PURINE (pro-Vitamin D)
and muscle F-1,6-BP
Xanthine METABOLISM *Skin(UV)
Xanthine
LEUBERING-RAPPOPORT oxidase KETOGENESIS Cholecalciferol
Adipose tissue DHAP GA3P HMG-CoA
SHUNT Uric acid *Mitochondrial
(D3)
matrix
Glycerol-3-P 1,3-BP-Glycerate *Liver
2,3-Diphosphoglycerate Calcidiol
Glycerol-1-P 3-Phosphoglycerate ALCOHOL Acetoacetyl CoA
Acetoacetic acid (25-hydroxy VitD)
BREAKDOWN
*Kidney
Glycerol Phosphoenolpyruvate Ethanol
Calcitriol
2 x Acetyl CoA (1,25-dihydroxy Vit D)
GLUCONEOGENESIS Acetaldehyde
Acetone β-hydroxybutarate
*Liver
Body
Acetate
proteins
Pyruvate dehydrogenase (Irreversible)
Alanine Pyruvate Acetyl-CoA
*From muscle *Mitochondria TRANSAMINATION REACTION
tyl-
*Muscle Cori cycle Ace
LIPOLYSIS
N aining ain Aspartate
I O
Lipase
*Liver T em ch
Lactate
X IDA R CoA
β-O
Glutamine Glutamate Alanine GLUCONEOGENESIS
GLUCONEOGENESIS *Excreted by
*Liver *Liver
kidneys
LIPOGENESIS
HAEM BREAKDOWN
TAG Fatty acid Malonyl-CoA
Lipase
*Spleen *Kidney Urine
FATTY ACID SYNTHESIS Biliverdin Bilirubin
*Cytosol *Liver Bile Faeses
*Intestine
Citrate *MM *Cytosol
Aspartate Oxaloacetate Haem Protoporphyrin Protoporphyrinogen Coproporphyrinogen
IX IX III
Isocitrate
Malate TCA CYCLE
UREA *Mitochondrial α-ketoglutarate *Cytosol Uroporphyrinogen III
5-Aminolinoleic Porphobilinogen
CYCLE Fumarate matrix(MM)
acid Uroporphyrinogen I
*MM
*Cytosol & MM of Succinyl-CoA
hepatocytes Succinate HEAM SYNTHESIS
Urea
, HOMEOSTASIS INTERMEDIARY METABOLISM
basiclivingunit
cells aggregates of differentcells held together by intracellular supporting structures organ
fluidcompartments 60 body fluid Icf 40 l of bodyweight
CCF 20 l of body weight Blood plasma interstitial fluid
CCfi largeamounts of Nat ch g Hoos ions ICF i large amounts of Kt Mg P ions
nutrients
Oz glucose fd aa
CO2 4 other waste transported to
lungs kidneys for excretion
internal environment
t
in constant motion transported in circulating blood mixed between blood
tissue fluids by diffusion through capillary walls
ions nutrients surrounds all cells
GLYCOLYSIS ppp CHOLESTEROL
PENTOSE PHOSPHATE SYNTHESIS
Glucose
PATHWAY Cholesterol esters
GLYCOGENESIS
PURINE Cell membranes
G-1-P G-6-P Ribulase-6-phosphate Ribose-5-phosphate Steroids
(Irreversible redox stage) SYNTHESIS Cholesterol VIT D
Bile salts
F-6-P
(Reversible interconversion stage)
*Li
SYNTHESIS
Glycogen *RBC & nondividing cells Hypoxanthine ver
*Stored in liver
Lansterol 7-dehydrocholesterol
PURINE (pro-Vitamin D)
and muscle F-1,6-BP
Xanthine METABOLISM *Skin(UV)
Xanthine
LEUBERING-RAPPOPORT oxidase KETOGENESIS Cholecalciferol
Adipose tissue DHAP GA3P HMG-CoA
SHUNT Uric acid *Mitochondrial
(D3)
matrix
Glycerol-3-P 1,3-BP-Glycerate *Liver
2,3-Diphosphoglycerate Calcidiol
Glycerol-1-P 3-Phosphoglycerate ALCOHOL Acetoacetyl CoA
Acetoacetic acid (25-hydroxy VitD)
BREAKDOWN
*Kidney
Glycerol Phosphoenolpyruvate Ethanol
Calcitriol
2 x Acetyl CoA (1,25-dihydroxy Vit D)
GLUCONEOGENESIS Acetaldehyde
Acetone β-hydroxybutarate
*Liver
Body
Acetate
proteins
Pyruvate dehydrogenase (Irreversible)
Alanine Pyruvate Acetyl-CoA
*From muscle *Mitochondria TRANSAMINATION REACTION
tyl-
*Muscle Cori cycle Ace
LIPOLYSIS
N aining ain Aspartate
I O
Lipase
*Liver T em ch
Lactate
X IDA R CoA
β-O
Glutamine Glutamate Alanine GLUCONEOGENESIS
GLUCONEOGENESIS *Excreted by
*Liver *Liver
kidneys
LIPOGENESIS
HAEM BREAKDOWN
TAG Fatty acid Malonyl-CoA
Lipase
*Spleen *Kidney Urine
FATTY ACID SYNTHESIS Biliverdin Bilirubin
*Cytosol *Liver Bile Faeses
*Intestine
Citrate *MM *Cytosol
Aspartate Oxaloacetate Haem Protoporphyrin Protoporphyrinogen Coproporphyrinogen
IX IX III
Isocitrate
Malate TCA CYCLE
UREA *Mitochondrial α-ketoglutarate *Cytosol Uroporphyrinogen III
5-Aminolinoleic Porphobilinogen
CYCLE Fumarate matrix(MM)
acid Uroporphyrinogen I
*MM
*Cytosol & MM of Succinyl-CoA
hepatocytes Succinate HEAM SYNTHESIS
Urea
, HOMEOSTASIS INTERMEDIARY METABOLISM
basiclivingunit
cells aggregates of differentcells held together by intracellular supporting structures organ
fluidcompartments 60 body fluid Icf 40 l of bodyweight
CCF 20 l of body weight Blood plasma interstitial fluid
CCfi largeamounts of Nat ch g Hoos ions ICF i large amounts of Kt Mg P ions
nutrients
Oz glucose fd aa
CO2 4 other waste transported to
lungs kidneys for excretion
internal environment
t
in constant motion transported in circulating blood mixed between blood
tissue fluids by diffusion through capillary walls
ions nutrients surrounds all cells
