UAMS IMMUNOLOGY EXAM 5
QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GUARANTEED
SUCCESS!!!
Question 1: Which statement correctly describes the primary diagnostic role
and characteristics of treponemal tests (such as FTA-ABS or TP-PA)?
A. They use cardiolipin antigen to screen for tissue damage non-specifically
B. They detect antibodies specific to treponemal antigens and serve as
sensitive, specific confirmatory tests
C. They are simple non-specific rapid screening tests performed on urine samples
D. They only become positive during the tertiary stage of infection
✔✔ Correct Answer: B (Treponemal tests detect antibodies directly targeting T.
pallidum antigens, making them high-specificity confirmatory assays).
Question 2: Non-treponemal tests such as VDRL (Venerable Disease Research
Laboratory) and RPR (Rapid Plasma Reagin) rely on which antigen to detect
reaginic antibodies?
A. Treponemal recombinant protein
B. Cardiolipin (often with lecithin and cholesterol)
C. Outer membrane protein A
D. Flagellar antigen
✔✔ Correct Answer: B (Non-treponemal screening tests detect anti-cardiolipin
antibodies produced in response to host cellular injury and spirochete damage).
Question 3: Which of the following is an accurate feature of non-treponemal
screening tests (VDRL, RPR)?
A. They are non-specific screening tests that turn positive in early stages of
syphilis
B. They serve as the gold-standard confirmatory test for Treponema pallidum
C. They remain positive for life regardless of effective antibiotic therapy
QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GUARANTEED
SUCCESS!!!
Question 1: Which statement correctly describes the primary diagnostic role
and characteristics of treponemal tests (such as FTA-ABS or TP-PA)?
A. They use cardiolipin antigen to screen for tissue damage non-specifically
B. They detect antibodies specific to treponemal antigens and serve as
sensitive, specific confirmatory tests
C. They are simple non-specific rapid screening tests performed on urine samples
D. They only become positive during the tertiary stage of infection
✔✔ Correct Answer: B (Treponemal tests detect antibodies directly targeting T.
pallidum antigens, making them high-specificity confirmatory assays).
Question 2: Non-treponemal tests such as VDRL (Venerable Disease Research
Laboratory) and RPR (Rapid Plasma Reagin) rely on which antigen to detect
reaginic antibodies?
A. Treponemal recombinant protein
B. Cardiolipin (often with lecithin and cholesterol)
C. Outer membrane protein A
D. Flagellar antigen
✔✔ Correct Answer: B (Non-treponemal screening tests detect anti-cardiolipin
antibodies produced in response to host cellular injury and spirochete damage).
Question 3: Which of the following is an accurate feature of non-treponemal
screening tests (VDRL, RPR)?
A. They are non-specific screening tests that turn positive in early stages of
syphilis
B. They serve as the gold-standard confirmatory test for Treponema pallidum
C. They remain positive for life regardless of effective antibiotic therapy
