UAMS MOLECULAR DIAGNOSTICS
FINAL EXAM REVIEW QUESTIONS AND
ANSWERS WITH COMPLETE
SOLUTIONS ALREADY PASSED!!!
What are the primary clinical and forensic applications of molecular testing?
✔✔ Infectious Diseases: Detection and quantification of viral, bacterial, and
fungal pathogens (e.g., PCR, viral load testing, resistance gene detection).
✔✔ Genetic Diseases: Identification of inherited single-gene mutations and
chromosomal disorders (e.g., cystic fibrosis, sickle cell anemia).
✔✔ Oncology: Detection of cancer-associated somatic mutations, translocations,
and prognostic gene expression signatures.
✔✔ Histocompatibility Testing (HLA): Human leukocyte antigen typing for
organ and stem cell transplantation compatibility.
✔✔ Human Identity Testing: Forensic DNA fingerprinting, paternity testing, and
criminal investigations.
What was the major scientific accomplishment of Gregor Mendel?
✔✔ Discovered the basic laws of inheritance (demonstrating through pea plant
experiments that traits are passed down in predictable, discrete units—now known
as genes—following dominant and recessive patterns).
What was the major scientific accomplishment of Friedrich Miescher?
✔✔ Discovered DNA in 1869 (isolating a unique phosphorus-rich, acidic
substance from the nuclei of white blood cells, which he initially termed "nuclein").
Briefly describe the scientific accomplishments of:
Griffith
, proved transformation. genetic material from one cell can be transferred into
another cell
Briefly describe the scientific accomplishments of:
Avery, MacLeod, and McCarty
proved that DNA is the hereditary material
Briefly describe the scientific accomplishments of:
Chargaff
A=T, G=C
Briefly describe the scientific accomplishments of:
Franklin and Wilkins
X-ray diffraction studies
Briefly describe the scientific accomplishments of:
Watson and Crick
discovered double helix
Characteristics of DNA
Nitrogen Bases: A G T C
FINAL EXAM REVIEW QUESTIONS AND
ANSWERS WITH COMPLETE
SOLUTIONS ALREADY PASSED!!!
What are the primary clinical and forensic applications of molecular testing?
✔✔ Infectious Diseases: Detection and quantification of viral, bacterial, and
fungal pathogens (e.g., PCR, viral load testing, resistance gene detection).
✔✔ Genetic Diseases: Identification of inherited single-gene mutations and
chromosomal disorders (e.g., cystic fibrosis, sickle cell anemia).
✔✔ Oncology: Detection of cancer-associated somatic mutations, translocations,
and prognostic gene expression signatures.
✔✔ Histocompatibility Testing (HLA): Human leukocyte antigen typing for
organ and stem cell transplantation compatibility.
✔✔ Human Identity Testing: Forensic DNA fingerprinting, paternity testing, and
criminal investigations.
What was the major scientific accomplishment of Gregor Mendel?
✔✔ Discovered the basic laws of inheritance (demonstrating through pea plant
experiments that traits are passed down in predictable, discrete units—now known
as genes—following dominant and recessive patterns).
What was the major scientific accomplishment of Friedrich Miescher?
✔✔ Discovered DNA in 1869 (isolating a unique phosphorus-rich, acidic
substance from the nuclei of white blood cells, which he initially termed "nuclein").
Briefly describe the scientific accomplishments of:
Griffith
, proved transformation. genetic material from one cell can be transferred into
another cell
Briefly describe the scientific accomplishments of:
Avery, MacLeod, and McCarty
proved that DNA is the hereditary material
Briefly describe the scientific accomplishments of:
Chargaff
A=T, G=C
Briefly describe the scientific accomplishments of:
Franklin and Wilkins
X-ray diffraction studies
Briefly describe the scientific accomplishments of:
Watson and Crick
discovered double helix
Characteristics of DNA
Nitrogen Bases: A G T C
