PMHNP Certification 2027 - Practice Questions and Answers -
Verified Accurate
Question 1.
The study of what drugs do and how they do it.
Correct Answer: Pharmacology
Question 2.
Study of what the body does to drugs; includes absorption, distribution, metabolism, and
excretion.
Correct Answer: Pharmacokinetics
Question 3.
Study of what drugs do to the body; target sites for drug actions include receptors, ion
channels, enzymes, and carrier proteins.
Correct Answer: Pharmacodynamics
Question 4.
Method and rate at which drugs leave the site of administration.
Correct Answer: Absorption
Question 5.
Where does absorption normally happen with oral medications?
Correct Answer: Small intestines then liver
Question 6.
Occurs after the drug leaves the systemic circulation and enters the interstitium and
cells.
Correct Answer: Distribution
Question 7.
Most psychotropic medications are __________ and highly __________.
Correct Answer: lipophilic; protein-bound
Question 8.
Most psychotropic medications are lipophilic and highly protein-bound. Only the
unbound (free) portion of the drug is active. Therefore, people with low protein
(albumin) levels, such as in malnutrition, wasting, or aging, can potentially
, experience____________ from an increased amount of free drug. People with high
fat-to-lean body mass ratio (as in older adults) will have __________ amounts of active
drug in their system.
Correct Answer: toxicity; erratic
Question 9.
Process by which the drug becomes chemically altered in the body.
Correct Answer: Metabolism
Question 10.
Process by which the drug is metabolized by cytochrome P450 (P450) enzymes in the
intestines and liver prior to going to the systemic circulation.
Correct Answer: First-pass metabolism
Question 11.
Process by which the drug is removed from the body.
Correct Answer: Elimination
• Time needed to clear 50% of the drug from the plasma. -✓✓Half-life
Question 12.
Point at which the amount of drug eliminated between doses is approximately equal to
the dose administered.
Correct Answer: Steady state
Question 13.
Drugs usually are administered ________ every half-life to achieve a steady state
Correct Answer: once
Question 14.
It takes approximately ___________ half-lives to achieve a steady state and five half-lives
to completely eliminate a drug.
Correct Answer: five
Question 15.
Hepatic cytochrome ________ enzyme interactions can induce or inhibit the metabolism
of certain drugs, thus changing their desired concentration levels.
Correct Answer: P450
Verified Accurate
Question 1.
The study of what drugs do and how they do it.
Correct Answer: Pharmacology
Question 2.
Study of what the body does to drugs; includes absorption, distribution, metabolism, and
excretion.
Correct Answer: Pharmacokinetics
Question 3.
Study of what drugs do to the body; target sites for drug actions include receptors, ion
channels, enzymes, and carrier proteins.
Correct Answer: Pharmacodynamics
Question 4.
Method and rate at which drugs leave the site of administration.
Correct Answer: Absorption
Question 5.
Where does absorption normally happen with oral medications?
Correct Answer: Small intestines then liver
Question 6.
Occurs after the drug leaves the systemic circulation and enters the interstitium and
cells.
Correct Answer: Distribution
Question 7.
Most psychotropic medications are __________ and highly __________.
Correct Answer: lipophilic; protein-bound
Question 8.
Most psychotropic medications are lipophilic and highly protein-bound. Only the
unbound (free) portion of the drug is active. Therefore, people with low protein
(albumin) levels, such as in malnutrition, wasting, or aging, can potentially
, experience____________ from an increased amount of free drug. People with high
fat-to-lean body mass ratio (as in older adults) will have __________ amounts of active
drug in their system.
Correct Answer: toxicity; erratic
Question 9.
Process by which the drug becomes chemically altered in the body.
Correct Answer: Metabolism
Question 10.
Process by which the drug is metabolized by cytochrome P450 (P450) enzymes in the
intestines and liver prior to going to the systemic circulation.
Correct Answer: First-pass metabolism
Question 11.
Process by which the drug is removed from the body.
Correct Answer: Elimination
• Time needed to clear 50% of the drug from the plasma. -✓✓Half-life
Question 12.
Point at which the amount of drug eliminated between doses is approximately equal to
the dose administered.
Correct Answer: Steady state
Question 13.
Drugs usually are administered ________ every half-life to achieve a steady state
Correct Answer: once
Question 14.
It takes approximately ___________ half-lives to achieve a steady state and five half-lives
to completely eliminate a drug.
Correct Answer: five
Question 15.
Hepatic cytochrome ________ enzyme interactions can induce or inhibit the metabolism
of certain drugs, thus changing their desired concentration levels.
Correct Answer: P450
