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CARN AP Exam Questions | Detailed Verified Answers | A Grade | 2026

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Ace the CARN-AP (Certified Addictions Registered Nurse-Advanced Practice) exam with this comprehensive study guide featuring detailed verified answers for 2026. Covers advanced addictions nursing, pharmacotherapy for SUD (methadone, buprenorphine, naltrexone, disulfiram, acamprosate, varenicline, bupropion), benzodiazepine/alcohol withdrawal management, motivational interviewing (OARS, stages of change), psychopharmacology (dopamine, GABA, glutamate, serotonin), screening tools (CAGE, AUDIT, MAST, COWS, HONC), and evidence-based treatment modalities.

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CARN AP EXAM QUESTIONS WITH
DETAILED, VERIFIED ANSWERS; A GRADE;
2026


2018 National Survey on Drug Use reports the rates of heavy
drinking are - correct answer- 6-7%


A 35 year old man with opioid use disorder (prescription
opioids which progressed to illicit opioids) has initiated office
-
based treatment with buprenorphine, advanced to 16mg per
day. He reports ceasing opioid use, and his urine toxicologies
are consistently positive for buprenorphine as prescribed with
intermittent results positive for benzodiazepines; he also
describes drinking alcohol two days per week, sometimes to
intoxication.

What is the most appropriate next step in his
treatment?
A.
Increase buprenorphine to 24mg

,B.
Refer to methadone maintenance
C.
Admit to inpatient detoxification
D.
Start an outpatient long
-
acting benzodiazepine taper
E.
Obtain more history - correct answer- Answer:
E
-
Obtain more history


Above what blood alcohol level can be fatal? - correct
answer- >600mg%


Acamprosate (Campral) - correct answer- Helps client
abstain from alcohol
-Dampens glutamate activity to curb hyper-excitability
associated with alcohol withdrawal

,Acamprosate (Campral) does what to GABA and glutamate levels
- - correct answer- Brings up the GABA and brings
down the glucamate


Acamprosate (Campral) dosing - correct answer-
333mg PO daily


Acamprosate (Campral) Indication - correct answer-
Maintenance of abstinence, reduces post-acute withdrawal
symptoms


Action of benz - correct answer- Increase GABA
activity to reduce excitability associated with alcohol withdrawal


Action Stage of Change Model - correct answer- In this
stage, people have recently changed their behavior (defined as
within the last 6 months) and intend to keep moving forward
with that behavior change. People may exhibit this by modifying
their problem behavior or acquiring new healthy behaviors.


Agnonist - correct answer- a molecule that increases a
neurotransmitter's action

, Alprazolam (Xanax) - correct answer- Benzodiazepine


Amphetamine toxicity causes BLANK pupils - correct
answer- Dilated


Amphetamines increase the activity of the neurotransmitters
(two) - correct answer- Dopamine and norepinephrine


Amphetamines work by blocking the reuptake of what two
transmitters? - correct answer- Norepinephrine and
dopamine


Analeptics - correct answer- Drugs that stimulate the
respiratory center


Antagonist - correct answer- Opponent, blocks the
receptor


At what blood alcohol level can coma occur? - correct
answer- 400-600mg%

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