NUR 3250 PHARMACOLOGY EXAM 1 VERIFIED
STUDY GUIDE
anxiety - Answers - Unpleasant feeling of tension, fear, or nervousness in response to
an environmental stimulus, whether real or imaginary
major depression - Answers - a disorder characterized by severe negative moods or a
lack of interest in normally pleasurable activities; thought to be caused by brain
deficiency of major neurotransmitters
aspirin - Answers - - salicylate
- available OTC
- most widely used for treating inflammation
- prevents heart attacks at a small dose
- Do not give to children
salicylates - Answers - - anti-inflammatory
- antipyretic
- analgesic
- inhibit synthesis or prostaglandins (cause inflammatory reaction); blocks pyrogens
(increase body temp)
CNS depressants, hypnotics, sedatives - Answers - block the awareness and reaction
to the environmental stimuli; induce drowsiness and calming effects
dopamine - Answers - Involved in fine motor movement, integration of emotions and
thoughts, decision making and coordination of impulses
serotonin - Answers - Responsible for arousal, sleep, hunger, mood, pain perception
norepinephrine - Answers - - plays an important role in the fight or flight response,
mood, attention, and arousal
- responsible for rise in BP, HR, and blood glucose when released into blood stream
tyramine - Answers - - found in food that causes vasoconstriction and raises blood
pressure
- drug-food interactions with MAOI poses the risk or a severe hypertensive crisis
acetaminophen - Answers - - Widely used agent
- Antipyretic and analgesic properties
- Does not have anti-inflammatory effects of the salicylates of the NSAIDs
- most frequently used for treating pain and fever in children
- acts on hypothalamus
, acetylcysteine - Answers - Can be used as an antidote the overdose of acetaminophen
NSAIDs black box warning - Answers - pointing out CV and GI bleeding risks (could
lead to death)
Prostaglandins - Answers - - made at the site of the inflammation, and they cause the
inflammatory factors
Ø Pain
Ø Fever
Ø Part of the healing process
NSAID side effects - Answers - GI effects, bleeding, headaches, dizziness, fatigue,
platelet inhibition, bone marrow depression
NSAID medications and indications - Answers - - block the COX (causes pain through
prostaglandins)
- Naproxen
- Celecoxib
- Ibuprofen (can cause peptic ulcer or gastritis)
- Treatment of pain, arthritis, juvenile arthritis, dysmenorrhea,
arthritis - Answers - The swelling of one or more joints; joint pain and stiffness
Osteoarthritis: wear and tear of the cartilage in joints
Rheumatoid arthritis: immune system attacks joints
COX-2 Inhibitors - Answers - - NSAID
- act on the sites of trauma and injury by blocking the inflammatory reaction
- risk of Steven-Johnson's syndrome
- Celecoxib
lidocaine - Answers - - Anesthetic
- Short-acting preferred for short procedures
dangerous if absorbed systemically
Tricyclic Antidepressants (TCAs) - Answers - - block the reuptake of serotonin and
norepinephrine (more in synaptic cleft)
- not first choice because they have more serious side effects
- Nortriptyline
- Amitriptyline
- Amoxapine
Tricyclic Antidepressants (TCAs) indications - Answers - - depression
- anxiety
- enuresis in children
- OCD
STUDY GUIDE
anxiety - Answers - Unpleasant feeling of tension, fear, or nervousness in response to
an environmental stimulus, whether real or imaginary
major depression - Answers - a disorder characterized by severe negative moods or a
lack of interest in normally pleasurable activities; thought to be caused by brain
deficiency of major neurotransmitters
aspirin - Answers - - salicylate
- available OTC
- most widely used for treating inflammation
- prevents heart attacks at a small dose
- Do not give to children
salicylates - Answers - - anti-inflammatory
- antipyretic
- analgesic
- inhibit synthesis or prostaglandins (cause inflammatory reaction); blocks pyrogens
(increase body temp)
CNS depressants, hypnotics, sedatives - Answers - block the awareness and reaction
to the environmental stimuli; induce drowsiness and calming effects
dopamine - Answers - Involved in fine motor movement, integration of emotions and
thoughts, decision making and coordination of impulses
serotonin - Answers - Responsible for arousal, sleep, hunger, mood, pain perception
norepinephrine - Answers - - plays an important role in the fight or flight response,
mood, attention, and arousal
- responsible for rise in BP, HR, and blood glucose when released into blood stream
tyramine - Answers - - found in food that causes vasoconstriction and raises blood
pressure
- drug-food interactions with MAOI poses the risk or a severe hypertensive crisis
acetaminophen - Answers - - Widely used agent
- Antipyretic and analgesic properties
- Does not have anti-inflammatory effects of the salicylates of the NSAIDs
- most frequently used for treating pain and fever in children
- acts on hypothalamus
, acetylcysteine - Answers - Can be used as an antidote the overdose of acetaminophen
NSAIDs black box warning - Answers - pointing out CV and GI bleeding risks (could
lead to death)
Prostaglandins - Answers - - made at the site of the inflammation, and they cause the
inflammatory factors
Ø Pain
Ø Fever
Ø Part of the healing process
NSAID side effects - Answers - GI effects, bleeding, headaches, dizziness, fatigue,
platelet inhibition, bone marrow depression
NSAID medications and indications - Answers - - block the COX (causes pain through
prostaglandins)
- Naproxen
- Celecoxib
- Ibuprofen (can cause peptic ulcer or gastritis)
- Treatment of pain, arthritis, juvenile arthritis, dysmenorrhea,
arthritis - Answers - The swelling of one or more joints; joint pain and stiffness
Osteoarthritis: wear and tear of the cartilage in joints
Rheumatoid arthritis: immune system attacks joints
COX-2 Inhibitors - Answers - - NSAID
- act on the sites of trauma and injury by blocking the inflammatory reaction
- risk of Steven-Johnson's syndrome
- Celecoxib
lidocaine - Answers - - Anesthetic
- Short-acting preferred for short procedures
dangerous if absorbed systemically
Tricyclic Antidepressants (TCAs) - Answers - - block the reuptake of serotonin and
norepinephrine (more in synaptic cleft)
- not first choice because they have more serious side effects
- Nortriptyline
- Amitriptyline
- Amoxapine
Tricyclic Antidepressants (TCAs) indications - Answers - - depression
- anxiety
- enuresis in children
- OCD
