MICROBIOLOGY FINAL EXAM PORTAGE LEARNING
| URGENT EMERGENCIES | QUESTIONS AND
CORRECT ANSWERS | UNIVERSITY OF TEXAS AT
ARLINGTON
Mrs. J, age 76, has experienced a slow, insidious memory decline across
5 years. She has become socially withdrawn and shows some language
difficulties. She has had peptic ulcer disease and often does not take
medications as prescribed.
Her psychiatrist diagnoses probable ____ and chooses_________with its easy
dosing schedule because of Mrs. J's history of nonadherence.
Alzheimers Dementia
Donepezil
Donepezil's GI tolerability is also a factor in this choice because of the
patient's peptic ulcer disease.
,Mr. L, age 82, has gradually developed memory loss and parkinsonian
symptoms, including slowness of movement and shuffling gait. He has
visual hallucinations of people and episodic confusion. His medications
include warfarin and digoxin for atrial fibrillation and congestive heart
failure.
Mr. L is diagnosed with probable dementia with____. His psychiatrist
chooses__________because it has shown efficacy in this type of dementia
and is not known to interact significantly with cardiovascular
medications.
Lewy bodies
Rivastigmine
Mrs. D, age 68, has a history of hypertension and suffered a stroke in the
past. Her family says her memory and behavior—anger outbursts and
excessive irritability—have worsened rapidly across 2 years. Examination
reveals some focal neurologic deficits.
Her psychiatrist diagnoses probable_____ dementia and chooses ______ for
its efficacy in patients with this dementia type. Mrs. D has no history of
GI illness and will likely tolerate the drug's GI side effects. Follow-up
care will include monitoring for tolerability.
vascular dementia
galantamine
Donepezil inhibits the enzyme ____.
acetylcholinesterase
, rivastigmine inhibits ______ and _________
acetylcholinesterase and butyrylcholinesterase
Galantamine inhibits ___________________________ and shows allosteric
modulation of the presynaptic ____ receptor.
acetylcholinesterase
nicotinic
Data indicating that_____ is particularly effective in patients with rapidly
progressive illness is consistent with the possible advantage of inhibiting
both butyrylcholinesterase and acetylcholinesterase.
rivastigmine
Donepezil and galantamine are metabolized by isoenzymes ____ and ___ ,
and undergo glucuronidation
2D6 & 3A4
Because rivastigmine avoids ____ metabolism, interactions with drugs
metabolized by CYP-450 isoenzymes have not been reported
hepatic
Donepezil interacts with ______ & ________
ketoconazole and quinidine
Stimulants for ADHD like Adderall, Ritalin increase ____ and ____ levels.
This improve attention and reduce hyperactivity/impulsivity
dopamine & norepinephrine