BSN 315 Pharmacology - Pharmacokinetics (ATSU PA 2013) – Questions With Expert Solutions

BSN 315 Pharmacology - Pharmacokinetics (ATSU PA
2013) – Questions With Expert Solutions

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- Easy to self-administer,
- low risk of systemic infection - toxicity/overdose may be reversible with antidotes
- Usually absorbed in duodenum
- Low pH of stomach may inactivate drug
- Subject to first-pass metabolism effect
- Slow onset



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1 Define: Pharmacokinetics 2 Topical Drug Administration

, 3 Drug Administration: Parenteral 4 Drug Administration by Mouth (PO)



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Terms in this set (68)



Define: Pharmacokinetics - What the body does to the drug
- ADME: Absorption, distribution, metabolism,
elimination


Define: Pharmacodynamics - What the drug does to the body
- Studies the specific MOA of drugs & its biochemical
and physiologic effects


Enteral Drug Administration Administering a drug by mouth (PO) or sublingual (SL)




Drug Administration by Mouth (PO) - Easy to self-administer,
- low risk of systemic infection - toxicity/overdose may
be reversible with antidotes
- Usually absorbed in duodenum
- Low pH of stomach may inactivate drug
- Subject to first-pass metabolism effect
- Slow onset


Drug Administration: Sublingual (SL) - Given under tongue
- Enters systemic circulation directly
- Avoids the harsh stomach environment & first-pass
metabolism
- Quick onset
e.g. SL nitroglycerin