Immunology Kuby Chapter 3 Receptors
and Signaling B and T-Cell Receptors
Questions With Answers
1. Which of the following types of bonds would be LEAST likely in a
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receptor-ligand interaction? |
A. Ionic bond
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B. Covalent bond
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C. Hydrogen bond
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D. Hydrophobic interaction
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E. Ionic bond - CORRECT ANSWER✔✔-Answer: B
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Section: Receptor-Ligand Interactions
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Difficulty: 2 |
Hint: Most receptor ligand interactions can be disrupted with high salt
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concentrations.
2. Ka, the association constant, is a measure of which of the following?
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A. The concentration of unbound ligand
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,B. The concentration of unbound receptor
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C. The affinity of receptor for ligand
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D. The size of the receptor relative to the ligand
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E. The number of ligands for each receptor - CORRECT ANSWER✔✔-
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Answer: C |
Section: Receptor-Ligand Interactions
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Difficulty: 2 |
Hint: It is the ratio of association rate constant over the dissociation rate
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constant.
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3. Receptors that are multivalent tend to bind to their ligands more
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strongly than receptors with a single binding site. What is the term used
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to describe this phenomenon?
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A. Avidity
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B. Valency
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C. Affinity
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D. Magnetism
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E. None of the above - CORRECT ANSWER✔✔-Answer: A
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Section: Receptor-Ligand Interactions
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Difficulty: 2 |
Hint: Affinity is factored into the calculation for avidity.
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, 4. Which of the following BEST describes how cytokines are released
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from activated T cells?
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A. Cytokines are released near where T-cell receptors are clustered.
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B. T cells release cytokines on the side of the cell opposite the MTOC in
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order to more efficiently distribute the response around the cell.
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C. T cells release cytokines evenly around the cell.
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D. Cytokines are released in short bursts from pre-formed vesicles full of
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cytokines.
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E. Cytokines are released in whatever direction the MTOC happens to be
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facing upon TCR ligation. - CORRECT ANSWER✔✔-Answer: A
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Section: Receptor-Ligand Interactions
| |
Difficulty: 1 |
Hint: The MTOC orients the secretory apparatus toward the T-cell
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receptors.
5. Receptors that dimerize upon ligand binding often
| | | | | | | |
contain______________in their cytoplasmic domains. | | |
A. tyrosine kinases
| |
B. hydrophobic regions
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C. proteases
|
and Signaling B and T-Cell Receptors
Questions With Answers
1. Which of the following types of bonds would be LEAST likely in a
| | | | | | | | | | | | | |
receptor-ligand interaction? |
A. Ionic bond
| |
B. Covalent bond
| |
C. Hydrogen bond
| |
D. Hydrophobic interaction
| |
E. Ionic bond - CORRECT ANSWER✔✔-Answer: B
| | | | | |
Section: Receptor-Ligand Interactions
| |
Difficulty: 2 |
Hint: Most receptor ligand interactions can be disrupted with high salt
| | | | | | | | | | |
concentrations.
2. Ka, the association constant, is a measure of which of the following?
| | | | | | | | | | | |
A. The concentration of unbound ligand
| | | | |
,B. The concentration of unbound receptor
| | | | |
C. The affinity of receptor for ligand
| | | | | |
D. The size of the receptor relative to the ligand
| | | | | | | | |
E. The number of ligands for each receptor - CORRECT ANSWER✔✔-
| | | | | | | | | |
Answer: C |
Section: Receptor-Ligand Interactions
| |
Difficulty: 2 |
Hint: It is the ratio of association rate constant over the dissociation rate
| | | | | | | | | | | |
constant.
|
3. Receptors that are multivalent tend to bind to their ligands more
| | | | | | | | | | | |
strongly than receptors with a single binding site. What is the term used
| | | | | | | | | | | | |
to describe this phenomenon?
| | |
A. Avidity
| |
B. Valency
|
C. Affinity
|
D. Magnetism
|
E. None of the above - CORRECT ANSWER✔✔-Answer: A
| | | | | | | |
Section: Receptor-Ligand Interactions
| |
Difficulty: 2 |
Hint: Affinity is factored into the calculation for avidity.
| | | | | | | |
, 4. Which of the following BEST describes how cytokines are released
| | | | | | | | | | |
from activated T cells?
| | |
A. Cytokines are released near where T-cell receptors are clustered.
| | | | | | | | |
B. T cells release cytokines on the side of the cell opposite the MTOC in
| | | | | | | | | | | | | | |
order to more efficiently distribute the response around the cell.
| | | | | | | | |
C. T cells release cytokines evenly around the cell.
| | | | | | | |
D. Cytokines are released in short bursts from pre-formed vesicles full of
| | | | | | | | | | |
cytokines.
|
E. Cytokines are released in whatever direction the MTOC happens to be
| | | | | | | | | | |
facing upon TCR ligation. - CORRECT ANSWER✔✔-Answer: A
| | | | | | | |
Section: Receptor-Ligand Interactions
| |
Difficulty: 1 |
Hint: The MTOC orients the secretory apparatus toward the T-cell
| | | | | | | | | |
receptors.
5. Receptors that dimerize upon ligand binding often
| | | | | | | |
contain______________in their cytoplasmic domains. | | |
A. tyrosine kinases
| |
B. hydrophobic regions
| |
C. proteases
|
