half-life
time to clear 50% of the drug from the plasma
inhibitory response
repolarization, involves the opening of chloride channels so chloride goes
into the cell, potassium leaves, or both
,first pass metabolism
process by which drug is metabolized by cytochrome p450 enzymes in the
intestines and liver prior to going to the systemic circulation
antagonist effect
drug binds to the receptor, but does not activate a biological response
Therapeutic index
ratio of toxic dose to median therapeutic dose
Inverse agonist effect
, Drug causes the opposite effect of agonist; binds to same receptor
Schedule IV
-medicinal drugs with less abuse potential than schedule III drugs
- examples: darvon, xanax, klonopin, valium, ambien, nuvigil (Armodafinil),
lunesta, temazepam,
enzyme inhibitors
increase the serum level of other drugs that are substrates of that enzyme,
thus possibly causing toxic levels
teratogenic effects from Lithium (Eskalith)
Epstein anomoly
time to clear 50% of the drug from the plasma
inhibitory response
repolarization, involves the opening of chloride channels so chloride goes
into the cell, potassium leaves, or both
,first pass metabolism
process by which drug is metabolized by cytochrome p450 enzymes in the
intestines and liver prior to going to the systemic circulation
antagonist effect
drug binds to the receptor, but does not activate a biological response
Therapeutic index
ratio of toxic dose to median therapeutic dose
Inverse agonist effect
, Drug causes the opposite effect of agonist; binds to same receptor
Schedule IV
-medicinal drugs with less abuse potential than schedule III drugs
- examples: darvon, xanax, klonopin, valium, ambien, nuvigil (Armodafinil),
lunesta, temazepam,
enzyme inhibitors
increase the serum level of other drugs that are substrates of that enzyme,
thus possibly causing toxic levels
teratogenic effects from Lithium (Eskalith)
Epstein anomoly
