NCLEX PHARMACOLOGY GASTROINTESTINAL DIGESTIVE SYSTEM TEST BANK MIDTERM EXAM 4 WITH COMPLETE QUESTIONS AND ANSWERS (VERIFIED ANSWERS) LATEST UPDATE FOR MIDTERM PREP

NCLEX PHARMACOLOGY GASTROINTESTINAL
DIGESTIVE SYSTEM TEST BANK MIDTERM EXAM 4
WITH COMPLETE QUESTIONS AND ANSWERS
(VERIFIED ANSWERS) LATEST UPDATE FOR
MIDTERM PREP 2026-2027



Antacids Drug–drug interactions


Affect the absorption of many other drugs


Proton Pump Inhibitors Drugs


–OmePRAZOLE (Prilosec)
–EsomePRAZOLE (Nexium)
–LansoPRAZOLE (Prevacid)
–DexlansoPRAZOLE (Dexilant)
–PantoPRAZOLE (Protonix)
–RabePRAZOLE (Aciphex)
• Used for GERD, ulcers

,Proton Pump Inhibitors Therapeutic actions


–Specifically inhibit the H+, K+–ATPase enzyme system on the secretory
surface of gastric parietal cells
• Blocks final step of acid production



Proton Pump Inhibitors Indications


-Short-term treatment of active duodenal ulcers, GERD, erosive
esophagitis, and benign active gastric disease
-Long-term treatment of pathological hypersecretory conditions
-Maintenance therapy for erosive esophagitis and ulcers


Proton Pump Inhibitors Contraindications


-Allergy
-Concurrent use with medications containing rilpivirine


Proton Pump Inhibitors Cautions


Pregnancy or lactation

, Proton Pump Inhibitors Adverse effects


–Related to effects on H+, K+–ATPase pump on the parietal and other
cells
–CNS effects
–GI effects
–Upper respiratory tract symptoms
–Long-term use: increase in bone loss, hypertension


Proton Pump Inhibitors Drug–drug interactions


-Benzodiazepines, phenytoin, warfarin
-Ketoconazole, theophylline
-Some antiretroviral medications


GI Protectant Drug


Sucralfate