1 | Page
NR293: Coagulation Modifier Drugs
(Chapter 26) Questions and Answers Latest
Update
What are the serious adverse effects of coagulation modifier drugs? Ans:
Bleeding from gums
Petechiae and purpura/ecchymosis
Hemarthroses
Hemoptysis
Blood in stool
Hematemesis
Epistaxis
What are the functions of heparin? Ans: Inactivates clotting factors II
(thrombin), Xa and IX.
What are the indications for heparin? Ans: Treatment of DVT/PE (IV)
Prevention of DVT/PE (SQ)
What labs would you monitor when administering heparin? Ans: Partial
thromboplastin time (aPTT) for continuous IV
Therapeutic goal: 60-80 seconds (1.5-2x normal level)
© 2025 All rights reserved
, 2 | Page
CBC (both SQ and IV)
Platelets for heparin-induced thrombocytopenia (HIT)
What is the antidote for heparin? Ans: Protamine sulfate
What are the functions of low-molecular weight heparin (LMWH)? Ans:
Inactive factor Xa
What are the indications for low-molecular weight heparin (LMWH)? Ans:
Treatment of DVT, PE
Prevent DVT in post-op clients
How would you administer low-molecular weight heparin (LMWH)? Ans:
Subcutaneous
Do not rub after administration
What labs would you monitor when administering low-molecular weight
heparin (LMWH)? Ans: None
More predictable anticoagulant response
What are the functions of coumarins? Ans: Inhibit Vit K-dependent clotting
factors
What are the indications for coumarins? Ans: Long-term anticoagulation
Prevent recurrent MI, TIA, thrombus formation
How would you administer coumarins? Ans: PO only
May be started while on heparin.
Discontinue heparin when PT-INR therapeutic.
© 2025 All rights reserved
NR293: Coagulation Modifier Drugs
(Chapter 26) Questions and Answers Latest
Update
What are the serious adverse effects of coagulation modifier drugs? Ans:
Bleeding from gums
Petechiae and purpura/ecchymosis
Hemarthroses
Hemoptysis
Blood in stool
Hematemesis
Epistaxis
What are the functions of heparin? Ans: Inactivates clotting factors II
(thrombin), Xa and IX.
What are the indications for heparin? Ans: Treatment of DVT/PE (IV)
Prevention of DVT/PE (SQ)
What labs would you monitor when administering heparin? Ans: Partial
thromboplastin time (aPTT) for continuous IV
Therapeutic goal: 60-80 seconds (1.5-2x normal level)
© 2025 All rights reserved
, 2 | Page
CBC (both SQ and IV)
Platelets for heparin-induced thrombocytopenia (HIT)
What is the antidote for heparin? Ans: Protamine sulfate
What are the functions of low-molecular weight heparin (LMWH)? Ans:
Inactive factor Xa
What are the indications for low-molecular weight heparin (LMWH)? Ans:
Treatment of DVT, PE
Prevent DVT in post-op clients
How would you administer low-molecular weight heparin (LMWH)? Ans:
Subcutaneous
Do not rub after administration
What labs would you monitor when administering low-molecular weight
heparin (LMWH)? Ans: None
More predictable anticoagulant response
What are the functions of coumarins? Ans: Inhibit Vit K-dependent clotting
factors
What are the indications for coumarins? Ans: Long-term anticoagulation
Prevent recurrent MI, TIA, thrombus formation
How would you administer coumarins? Ans: PO only
May be started while on heparin.
Discontinue heparin when PT-INR therapeutic.
© 2025 All rights reserved
