Test Bank For
The Immune System Fifth Edition Peter Parham
Chapter 1-17
CHAPTER 1: ELEMENTS OF THE IMMUNE SYSTEM AND
THEIR ROLES IN DEFENSE
1–1 The last cases of smallpox were reported in the _____.
a. 1950s
b. 1960s
c. 1970s
d. 1980s
e. 1990s.
1–2 The first line of defense against microorganisms that infect the body is referred to as
_____.
a. opportunistic immunity
b. innate immunity
c. adaptive immunity
d. primary immunity
e. central immunity.
1–3 Which of the following pairs is mismatched?
a. innate immunity: highly specialized defenses
b. secondary immune response: immunological memory
c. hematopoiesis: bone marrow
d. phagocytosis: uptake and killing of microbes
e. lymphocyte recirculation: continuous transport between blood and lymph.
1–4 All of the following are examples of chemical barriers of innate immunity except _____.
a. lactic acid
b. normal microbiota
c. lysozyme
d. fatty acids
e. proteases.
1–5 When effector lymphocytes secrete _____, an inflammatory response ensues.
a. lysozyme
b. defensins
c. lymph
d. sebum
e. cytokines.
1
,1–6 The thin layer of cells that makes up the interior lining of the blood vessels is called the
_____.
a. mucosa
b. epithelium
c. endothelium
d. connective tissue
e. lymphoid tissue.
1–7 Identify the incorrect statement regarding hematopoiesis.
a. Hematopoiesis is a continuous process that occurs throughout one‘s lifetime.
b. The location for hematopoiesis differs with age.
c. Self renewal is necessary to replenish the supply of hematopoietic stem cells.
d. Most hematopoiesis occurs in the bone marrow after birth.
e. Leukocytes, but not erythrocytes, must go through hematopoiesis in order to develop.
1–8 The progenitors of macrophages are _____.
a. megakaryocytes
b. dendritic cells
c. monocytes
d. neutrophils
e. erythrocytes
f. M cells.
1–9 _____ act as cellular messengers by delivering degraded pathogens to lymphoid organs.
a. Plasma cells
b. Dendritic cells
c. Large granular lymphocytes
d. Mast cells
e. Basophils.
1–10 Another name for a large granular lymphocyte is a _____.
a. plasma cell
b. helper T cell
c. monocyte
d. natural killer cell
e. eosinophil.
1–11 Effector cells that secrete antibodies are known as _____.
a. natural killer cells
b. cytotoxic T cells
c. helper T cells
d. M cells
e. plasma cells
f. regulatory T cells.
2
,1–12 Spherical regions in lymph nodes containing areas that are packed densely with
proliferating B cells are called _____.
a. efferent vessels
b. germinal centers
c. red pulp zones
d. periarterial lymphoid sheaths
e. medullary sinuses.
1–13 The _____ is (are) the lymphoid organ(s) that filter(s) the blood.
a. spleen
b. tonsils
c. Peyer‘s patches
d. appendix
e. adenoids.
1–14 _____ cells persist long after an individual has been vaccinated.
a. Neutrophil
b. Plasma
c. Memory
d. M
e. Mast.
1–15 During an infection, _____ are mobilized in large numbers from the bone marrow.
a. dendritic cells
b. memory cells
c. macrophages
d. neutrophils
e. B cells.
1–16 In most cases, adaptive immune responses rely on the initial activation of _____ in
secondary lymphoid tissue:
a. macrophages
b. T cells
c. B cells
d. dendritic cells
e. epithelium.
1–17 All of the following statements are characteristic of secondary immune responses except
_____.
a. Secondary immune responses are activated when primary immune responses fail to
completely eradicate an infection.
b. Secondary immune responses are restricted to adaptive immune responses.
c. Memory cells are activated rapidly during secondary immune responses.
d. Secondary immune responses are orders of magnitude greater than primary immune
responses.
3
, e. During a secondary immune response to a booster vaccine, it is possible to experience a
primary immune response to an unrelated vaccine component encountered for the first time.
1–18 Identify the four classes of pathogens that provoke immune responses in our bodies and
give an example of each.
1–19 A bacterium that causes a common disease in a population that has been previously
exposed to it is called _____.
a. opportunistic
b. resistant
c. commensal
d. endemic
e. attenuated.
1–20
A. Name the parts of the body where epithelia act as barriers to infection.
B. Describe the three main ways in which epithelia carry out this barrier function, giving
details of the mechanisms employed.
1–21 An example of an antimicrobial peptide that protects epithelial surfaces from pathogens is
_____.
a. glycoprotein
b. defensin
c. proteoglycan
d. lysozyme
e. sebum.
1–22 How can antibiotics upset the barrier function of intestinal epithelia? Give a specific
example.
1–23 Describe the characteristics commonly associated with inflammation and what causes
them.
1–24 Which of the following are characteristics of innate immunity:
a. inflammation
b. improvement in recognition of the pathogen during the response
c. fast response
d. highly specific for a particular pathogen
e. cytokine production.
1–25 Which of the following statements regarding neutrophils is false?
a. Neutrophils are mobilized from the bone marrow to sites of infection when needed.
b. Neutrophils are active only in aerobic conditions.
c. Neutrophils are phagocytic.
d. Neutrophils form pus, which comprises dead neutrophils.
e. Dead neutrophils are cleared from sites of infection by macrophages.
4
The Immune System Fifth Edition Peter Parham
Chapter 1-17
CHAPTER 1: ELEMENTS OF THE IMMUNE SYSTEM AND
THEIR ROLES IN DEFENSE
1–1 The last cases of smallpox were reported in the _____.
a. 1950s
b. 1960s
c. 1970s
d. 1980s
e. 1990s.
1–2 The first line of defense against microorganisms that infect the body is referred to as
_____.
a. opportunistic immunity
b. innate immunity
c. adaptive immunity
d. primary immunity
e. central immunity.
1–3 Which of the following pairs is mismatched?
a. innate immunity: highly specialized defenses
b. secondary immune response: immunological memory
c. hematopoiesis: bone marrow
d. phagocytosis: uptake and killing of microbes
e. lymphocyte recirculation: continuous transport between blood and lymph.
1–4 All of the following are examples of chemical barriers of innate immunity except _____.
a. lactic acid
b. normal microbiota
c. lysozyme
d. fatty acids
e. proteases.
1–5 When effector lymphocytes secrete _____, an inflammatory response ensues.
a. lysozyme
b. defensins
c. lymph
d. sebum
e. cytokines.
1
,1–6 The thin layer of cells that makes up the interior lining of the blood vessels is called the
_____.
a. mucosa
b. epithelium
c. endothelium
d. connective tissue
e. lymphoid tissue.
1–7 Identify the incorrect statement regarding hematopoiesis.
a. Hematopoiesis is a continuous process that occurs throughout one‘s lifetime.
b. The location for hematopoiesis differs with age.
c. Self renewal is necessary to replenish the supply of hematopoietic stem cells.
d. Most hematopoiesis occurs in the bone marrow after birth.
e. Leukocytes, but not erythrocytes, must go through hematopoiesis in order to develop.
1–8 The progenitors of macrophages are _____.
a. megakaryocytes
b. dendritic cells
c. monocytes
d. neutrophils
e. erythrocytes
f. M cells.
1–9 _____ act as cellular messengers by delivering degraded pathogens to lymphoid organs.
a. Plasma cells
b. Dendritic cells
c. Large granular lymphocytes
d. Mast cells
e. Basophils.
1–10 Another name for a large granular lymphocyte is a _____.
a. plasma cell
b. helper T cell
c. monocyte
d. natural killer cell
e. eosinophil.
1–11 Effector cells that secrete antibodies are known as _____.
a. natural killer cells
b. cytotoxic T cells
c. helper T cells
d. M cells
e. plasma cells
f. regulatory T cells.
2
,1–12 Spherical regions in lymph nodes containing areas that are packed densely with
proliferating B cells are called _____.
a. efferent vessels
b. germinal centers
c. red pulp zones
d. periarterial lymphoid sheaths
e. medullary sinuses.
1–13 The _____ is (are) the lymphoid organ(s) that filter(s) the blood.
a. spleen
b. tonsils
c. Peyer‘s patches
d. appendix
e. adenoids.
1–14 _____ cells persist long after an individual has been vaccinated.
a. Neutrophil
b. Plasma
c. Memory
d. M
e. Mast.
1–15 During an infection, _____ are mobilized in large numbers from the bone marrow.
a. dendritic cells
b. memory cells
c. macrophages
d. neutrophils
e. B cells.
1–16 In most cases, adaptive immune responses rely on the initial activation of _____ in
secondary lymphoid tissue:
a. macrophages
b. T cells
c. B cells
d. dendritic cells
e. epithelium.
1–17 All of the following statements are characteristic of secondary immune responses except
_____.
a. Secondary immune responses are activated when primary immune responses fail to
completely eradicate an infection.
b. Secondary immune responses are restricted to adaptive immune responses.
c. Memory cells are activated rapidly during secondary immune responses.
d. Secondary immune responses are orders of magnitude greater than primary immune
responses.
3
, e. During a secondary immune response to a booster vaccine, it is possible to experience a
primary immune response to an unrelated vaccine component encountered for the first time.
1–18 Identify the four classes of pathogens that provoke immune responses in our bodies and
give an example of each.
1–19 A bacterium that causes a common disease in a population that has been previously
exposed to it is called _____.
a. opportunistic
b. resistant
c. commensal
d. endemic
e. attenuated.
1–20
A. Name the parts of the body where epithelia act as barriers to infection.
B. Describe the three main ways in which epithelia carry out this barrier function, giving
details of the mechanisms employed.
1–21 An example of an antimicrobial peptide that protects epithelial surfaces from pathogens is
_____.
a. glycoprotein
b. defensin
c. proteoglycan
d. lysozyme
e. sebum.
1–22 How can antibiotics upset the barrier function of intestinal epithelia? Give a specific
example.
1–23 Describe the characteristics commonly associated with inflammation and what causes
them.
1–24 Which of the following are characteristics of innate immunity:
a. inflammation
b. improvement in recognition of the pathogen during the response
c. fast response
d. highly specific for a particular pathogen
e. cytokine production.
1–25 Which of the following statements regarding neutrophils is false?
a. Neutrophils are mobilized from the bone marrow to sites of infection when needed.
b. Neutrophils are active only in aerobic conditions.
c. Neutrophils are phagocytic.
d. Neutrophils form pus, which comprises dead neutrophils.
e. Dead neutrophils are cleared from sites of infection by macrophages.
4
