BIO 351 Exam
BIO 351 Exam 2 (50 Questions) & Answers
With Rationale New Update
1. In the mouse embryo, this tissue provides important cues that specify the anterior-
posterior orientation of the primitive streak. Name this tissue. - ANSWER ✔ - Anterior
Visceral Endoderm
2. During neural development, the dietary vitamin ____ is required for ____ closure. -
ANSWER ✔ - Folate, dorsal neural tube
3. Somite’s form in a ____ sequence. The location of somite formation is dependent upon a
gradient of _____, a patterning cute with high levels of expression in the caudal tail bud. -
ANSWER ✔ - Rostral to caudal, FGF8
4. Which of the following embryonic sources make the largest contribution to the cells
currently in your body? - ANSWER ✔ - Epiblast
5. Melanoblasts derive from neural crest that migrate from the ___ along the ___ pathway
near the epidermis. - ANSWER ✔ - Dorsal neural tube, dorsolateral
6. Which of the following represents an important outcome of heart looping? - ANSWER ✔
- Conversion of anterior-posterior asymmetry to left-right asymmetry
7. Disruptions of the formation of the primordial lung bud can lead to severe birth defects
involving the ____ and ____. - ANSWER ✔ - Esophagus, trachea
1|P A G E
, BIO 351 Exam
8. During the development of the gonads the cells of the genital ridge will invade the
underlying mesenchyme. What will the mesenchymal cells be induced to become? -
ANSWER ✔ - Leydig cells or theca cells
9. Which of the following images provides the best example of holoblastic cleavage of a
fertilized egg? - ANSWER ✔ - (holoblastic cleavage eans complete cleavage)
10. You have employed an induced pluripotent approach to reprogram fibroblasts into ES
cells. Now, you would like to stimulate these cells to generate neurons typically found in
the rhombomeres at the midbrain-hindbrain boundary. Which of the following cues
would be most useful for generating these neurons? - ANSWER ✔ - Sox2
11. Alligator eggs were incubated at thirtytwoC until the temperature sensitive period (TSP)
and then changed to thirtyfourC during the TSP. The resulting hatchlings will be ____
because the _____ enzyme is more active. - ANSWER ✔ - ~50% female, aromatase
12. Fosamax is commonly marketed drug that inhibits osteoclasts. Thus, you can conclude
that this drug is manufactured as a treatment for which of the following conditions? -
ANSWER ✔ - Osteoporosis
13. Disruption of the long, tube-like structures on the embryonic Nodel shown in the EM
images at right is closely linked to which of the following developmental defects? -
ANSWER ✔ - Cleft Palate~ should be situs invertus?
14. Genes with dynamic expression pattern shown below are described as _____ genes and
include genes in the ____ pathway. - ANSWER ✔ - Cycling, Notch
15. Which of the following is an important secreted cue for directing the development of
cardiac neural crest and cranial neural crest in the pharyngeal arches? - ANSWER ✔ -
FGF8
2|P A G E
BIO 351 Exam 2 (50 Questions) & Answers
With Rationale New Update
1. In the mouse embryo, this tissue provides important cues that specify the anterior-
posterior orientation of the primitive streak. Name this tissue. - ANSWER ✔ - Anterior
Visceral Endoderm
2. During neural development, the dietary vitamin ____ is required for ____ closure. -
ANSWER ✔ - Folate, dorsal neural tube
3. Somite’s form in a ____ sequence. The location of somite formation is dependent upon a
gradient of _____, a patterning cute with high levels of expression in the caudal tail bud. -
ANSWER ✔ - Rostral to caudal, FGF8
4. Which of the following embryonic sources make the largest contribution to the cells
currently in your body? - ANSWER ✔ - Epiblast
5. Melanoblasts derive from neural crest that migrate from the ___ along the ___ pathway
near the epidermis. - ANSWER ✔ - Dorsal neural tube, dorsolateral
6. Which of the following represents an important outcome of heart looping? - ANSWER ✔
- Conversion of anterior-posterior asymmetry to left-right asymmetry
7. Disruptions of the formation of the primordial lung bud can lead to severe birth defects
involving the ____ and ____. - ANSWER ✔ - Esophagus, trachea
1|P A G E
, BIO 351 Exam
8. During the development of the gonads the cells of the genital ridge will invade the
underlying mesenchyme. What will the mesenchymal cells be induced to become? -
ANSWER ✔ - Leydig cells or theca cells
9. Which of the following images provides the best example of holoblastic cleavage of a
fertilized egg? - ANSWER ✔ - (holoblastic cleavage eans complete cleavage)
10. You have employed an induced pluripotent approach to reprogram fibroblasts into ES
cells. Now, you would like to stimulate these cells to generate neurons typically found in
the rhombomeres at the midbrain-hindbrain boundary. Which of the following cues
would be most useful for generating these neurons? - ANSWER ✔ - Sox2
11. Alligator eggs were incubated at thirtytwoC until the temperature sensitive period (TSP)
and then changed to thirtyfourC during the TSP. The resulting hatchlings will be ____
because the _____ enzyme is more active. - ANSWER ✔ - ~50% female, aromatase
12. Fosamax is commonly marketed drug that inhibits osteoclasts. Thus, you can conclude
that this drug is manufactured as a treatment for which of the following conditions? -
ANSWER ✔ - Osteoporosis
13. Disruption of the long, tube-like structures on the embryonic Nodel shown in the EM
images at right is closely linked to which of the following developmental defects? -
ANSWER ✔ - Cleft Palate~ should be situs invertus?
14. Genes with dynamic expression pattern shown below are described as _____ genes and
include genes in the ____ pathway. - ANSWER ✔ - Cycling, Notch
15. Which of the following is an important secreted cue for directing the development of
cardiac neural crest and cranial neural crest in the pharyngeal arches? - ANSWER ✔ -
FGF8
2|P A G E
