CMB2004 UPDATED Exam Questions and
CORRECT Answers
What is the acquired immune response? - CORRECT ANSWER - Shows specificity to a
particular pathogen and exhibits memory
Describe clonal selection - CORRECT ANSWER - Potentially self reactive lymphocytes
are removed on early in development, leaves a pool of mature naive lymphocytes which upon
recognition of a foreign antigen will proliferate to form a clone of effector cells.
What is BCR expressed by? - CORRECT ANSWER - B cells
Is BCR membrane bound? - CORRECT ANSWER - Yes, but is secreted when the B cell
becomes active
What do BCR bind? - CORRECT ANSWER - Free antigen
What is TCR expressed by? - CORRECT ANSWER - T cells
Is TCR membrane bound? - CORRECT ANSWER - Yes, always
What does TCR recognise? - CORRECT ANSWER - Peptide fragments/antigens
presented by APC and MHC
What receptor do effector cells carry? - CORRECT ANSWER - FcR
What portion of the antibody do FCR bind? - CORRECT ANSWER - Fc portion
,Is the antigen binding site at the N terminus or C terminus? - CORRECT ANSWER -N
terminus
What chains form the antigen binding site on an antibody? - CORRECT ANSWER -
Variable regions of paired heavy and light chains
What are the two types of light chain? - CORRECT ANSWER - Lambda and kappa
What are the 5 antibody classes and what are they determined by? - CORRECT
ANSWER - MADGE, heavy chain
How many homology domains are in the L chain? - CORRECT ANSWER -2
How many homology domains are in the H chain? - CORRECT ANSWER - 4 or 5
What is in the homology domains of H and L chains? - CORRECT ANSWER - Beta
sheets held by disulphide bridges
How many hyper variable regions are there in L chain and H chain, therefore how many are there
in the antigen binding site? - CORRECT ANSWER - 3 in each, 6 hyper variable loops in
antigen binding site
What determines the specificity and affinity of antibodies for antigens? - CORRECT
ANSWER - The complementary determining regions in the V regions.
Is TCR always a heterodimer of alpha and beta? - CORRECT ANSWER - It can also be
delta and gamma
What type of cells express MHC class I? - CORRECT ANSWER - Nearly all nucleated
cells in the body
, What domains exist in MHC class 1? - CORRECT ANSWER - alpha1, alpha2, alpha3,
beta microglobulin
Which MHC class contains beta micro globulin? - CORRECT ANSWER - MHC class I
What type of cells express MHC class II? - CORRECT ANSWER - Specific immune cells
like APC
Which genes encode MHC class I? - CORRECT ANSWER - HLA-A, HLA-B, HLA-C
Which genes encode MHC class II? - CORRECT ANSWER - HLA-DP, DQ, DR
What domains do MHC class II molecules contain? - CORRECT ANSWER - alpha1,
beta1, alpha2, beta2
What can be co expressed alongside TCR on T cells? - CORRECT ANSWER - Either CD4
or CD8
Which three gene segments encode the V region of H chain? - CORRECT ANSWER -V
DJ
Which two gene segments encode the V region of L chain - CORRECT ANSWER - V and
J
In H gene rearrangement what is the order of rearrangement? - CORRECT ANSWER -
DJVD
In L gene rearrangement what is the order of rearrangement? - CORRECT ANSWER -
Kappa first, then VJ
CORRECT Answers
What is the acquired immune response? - CORRECT ANSWER - Shows specificity to a
particular pathogen and exhibits memory
Describe clonal selection - CORRECT ANSWER - Potentially self reactive lymphocytes
are removed on early in development, leaves a pool of mature naive lymphocytes which upon
recognition of a foreign antigen will proliferate to form a clone of effector cells.
What is BCR expressed by? - CORRECT ANSWER - B cells
Is BCR membrane bound? - CORRECT ANSWER - Yes, but is secreted when the B cell
becomes active
What do BCR bind? - CORRECT ANSWER - Free antigen
What is TCR expressed by? - CORRECT ANSWER - T cells
Is TCR membrane bound? - CORRECT ANSWER - Yes, always
What does TCR recognise? - CORRECT ANSWER - Peptide fragments/antigens
presented by APC and MHC
What receptor do effector cells carry? - CORRECT ANSWER - FcR
What portion of the antibody do FCR bind? - CORRECT ANSWER - Fc portion
,Is the antigen binding site at the N terminus or C terminus? - CORRECT ANSWER -N
terminus
What chains form the antigen binding site on an antibody? - CORRECT ANSWER -
Variable regions of paired heavy and light chains
What are the two types of light chain? - CORRECT ANSWER - Lambda and kappa
What are the 5 antibody classes and what are they determined by? - CORRECT
ANSWER - MADGE, heavy chain
How many homology domains are in the L chain? - CORRECT ANSWER -2
How many homology domains are in the H chain? - CORRECT ANSWER - 4 or 5
What is in the homology domains of H and L chains? - CORRECT ANSWER - Beta
sheets held by disulphide bridges
How many hyper variable regions are there in L chain and H chain, therefore how many are there
in the antigen binding site? - CORRECT ANSWER - 3 in each, 6 hyper variable loops in
antigen binding site
What determines the specificity and affinity of antibodies for antigens? - CORRECT
ANSWER - The complementary determining regions in the V regions.
Is TCR always a heterodimer of alpha and beta? - CORRECT ANSWER - It can also be
delta and gamma
What type of cells express MHC class I? - CORRECT ANSWER - Nearly all nucleated
cells in the body
, What domains exist in MHC class 1? - CORRECT ANSWER - alpha1, alpha2, alpha3,
beta microglobulin
Which MHC class contains beta micro globulin? - CORRECT ANSWER - MHC class I
What type of cells express MHC class II? - CORRECT ANSWER - Specific immune cells
like APC
Which genes encode MHC class I? - CORRECT ANSWER - HLA-A, HLA-B, HLA-C
Which genes encode MHC class II? - CORRECT ANSWER - HLA-DP, DQ, DR
What domains do MHC class II molecules contain? - CORRECT ANSWER - alpha1,
beta1, alpha2, beta2
What can be co expressed alongside TCR on T cells? - CORRECT ANSWER - Either CD4
or CD8
Which three gene segments encode the V region of H chain? - CORRECT ANSWER -V
DJ
Which two gene segments encode the V region of L chain - CORRECT ANSWER - V and
J
In H gene rearrangement what is the order of rearrangement? - CORRECT ANSWER -
DJVD
In L gene rearrangement what is the order of rearrangement? - CORRECT ANSWER -
Kappa first, then VJ
