CC2 1ST LE REVIEWER (CLINICAL SIGNIFICANCE OF ENZYMES; ENZYMOLOGY) QUESTIONS AND ANSWERS A+ 2025

CC2 1ST LE REVIEWER (CLINICAL SIGNIFICANCE OF ENZYMES; ENZYMOLOGY)
QUESTIONS AND ANSWERS A+ 2025
creatine kinase - ANS-✔✔an enzyme that is generally associated with ATP regeneration in contractile or
transport systems



creatine kinase - ANS-✔✔enzyme found in muscle cells involved in the storage of high energy creatine
phosphate



reversible - ANS-✔✔the reaction catalyzed by creatine kinase is REVERSIBLE/NON-REVERSIBLE



ATP - ANS-✔✔when creatine kinase reacts with creatine phosphate ATP/ADP is produced



ADP - ANS-✔✔when creatine kinase reacts with creatine ATP/ADP is produced



skeletal muscle

heart muscle

brain tissue - ANS-✔✔areas in the body with the highest creatine kinase activity



myocardial infarction

rhabdomyolysis

muscular dystrophy - ANS-✔✔creatine kinase is elevated in the following disorders



duchenne type - ANS-✔✔creatine kinase is a sensitive indicator of what type of muscular dystrophy



muscle mass

gender

,race

physical conditioning

age - ANS-✔✔factors that affect creatine kinase levels in the body



FALSE: creatine kinase, although sensitive is not a specific indicator of cardiac or skeletal muscle
conditions - ANS-✔✔creatine kinase is a sensitive and specific indicator of cardiac or skeletal muscle
conditions



males - ANS-✔✔gender in which higher creatine kinase levels are observed



africans - ANS-✔✔race in which higher creatine kinase levels are observed



TRUE - ANS-✔✔TRUE/FALSE: older people have lower creatine kinase levels than younger people



CK-MM - ANS-✔✔major creatine kinase isoenzyme in the sera of healthy people



CK-MM - ANS-✔✔creatine kinase isoenzyme commonly found in striated muscle and normal serum



striated muscle

normal serum - ANS-✔✔CK-MM is the major creatine kinase isoenzyme in these areas



CK-MM - ANS-✔✔major creatine kinase isoenzyme found in heart muscle



cardiac tissue (myocardium) - ANS-✔✔area of the body from which CK-MB enters the serum in
significant quantities

, >6% - ANS-✔✔CK-MB percentage considered as a good indicator of myocardial damage (ie. AMI)



4-8 hours - ANS-✔✔CK-MB levels rise after how many hours following myocardial infarction



12-24 hours - ANS-✔✔CK-MB levels peak after how many hours following myocardial infarction



48-72 hours - ANS-✔✔CK-MB levels return to normal levels after how many hours following myocardial
infarction



CNS

GIT

uterus during pregnancy - ANS-✔✔the highest concentrations of CK-BB is found in these areas of the
body



CK-BB - ANS-✔✔creatine kinase isoenzyme with the highest concentrations being found in the CNS,
GIT, and uterus (during pregnancy)



CK-MM

CK-MB - ANS-✔✔creatine kinase isoenzymes elevated in myocardial infarction



CK-MM - ANS-✔✔creatine kinase isoenzymes elevated in skeletal muscle disorder



CK-MM - ANS-✔✔creatine kinase isoenzymes elevated in muscular dystrophy



CK-MM

CK-MB - ANS-✔✔creatine kinase isoenzymes elevated in polymyositis