ONS Chemotherapy Immunotherapy Certificate
Questions 100% Solved | Already passed
What is unique about nitrosoureas agents? - ✔✔Able to cross the blood-brain barrier; can be effective
in treating some brain tumors
Common nitrosoureas agents: - ✔✔Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - ✔✔Carboplatin
These agents are typically categorized as highly emetogenic: - ✔✔1. Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - ✔✔BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - ✔✔Bladder protectant with administration
of cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days
following treatment - ✔✔Oxaliplatin
,How do antimetabolites function? - ✔✔By blocking DNA and RNA growth by interfering with
enzymes needed for normal cell metabolism
Antimetabolites work in the ___ phase. - ✔✔S
What types of cells are best affected by antimetabolites? - ✔✔Cells with high division rates
Common side effects of antimetabolites: - ✔✔Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Common antimetabolite drugs: - ✔✔Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
The institute for Safe Medication Practices recommends what route of administration for vincristine? -
✔✔IV piggyback via gravity
Anthracycline antitumor abx work by: - ✔✔Interfering with enzymes necessary for DNA to replicate
in ALL phases of the cell cycle
The two major classifications of antitumor antibiotics are: -
✔✔Anthracyclines Non-anthracyclines
, Common anthracycline antitumor abx: - ✔✔Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
The antitumor abx ___________ is not an anthracycline, but has anthracycline-type properties. -
✔✔Mitoxantrone
Common non-anthracycline antitumor abx: - ✔✔Actinomycin D
Mitomycin C
Bleomycin
Monitoring necessary with doxorubicin: - ✔✔Vesicant --> extravasation
Cardiac function
Lifetime dose tracking (cardiotoxicity)
Lifetime dose of doxorubicin should not exceed: - ✔✔550 mg/m^2
What cardiac protectant medication can be administered prior to doxorubicin? - ✔✔Dexrazoxane
Significant side effects of doxorubicin are: - ✔✔Cardiotoxicity
N/V
Mucositis
Diarrhea
Severe myelosuppression
Hepatic impairment
Secondary cancers
Monitoring necessary with bleomycin: - ✔✔Pulmonary toxicity
Questions 100% Solved | Already passed
What is unique about nitrosoureas agents? - ✔✔Able to cross the blood-brain barrier; can be effective
in treating some brain tumors
Common nitrosoureas agents: - ✔✔Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - ✔✔Carboplatin
These agents are typically categorized as highly emetogenic: - ✔✔1. Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - ✔✔BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - ✔✔Bladder protectant with administration
of cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days
following treatment - ✔✔Oxaliplatin
,How do antimetabolites function? - ✔✔By blocking DNA and RNA growth by interfering with
enzymes needed for normal cell metabolism
Antimetabolites work in the ___ phase. - ✔✔S
What types of cells are best affected by antimetabolites? - ✔✔Cells with high division rates
Common side effects of antimetabolites: - ✔✔Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Common antimetabolite drugs: - ✔✔Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
The institute for Safe Medication Practices recommends what route of administration for vincristine? -
✔✔IV piggyback via gravity
Anthracycline antitumor abx work by: - ✔✔Interfering with enzymes necessary for DNA to replicate
in ALL phases of the cell cycle
The two major classifications of antitumor antibiotics are: -
✔✔Anthracyclines Non-anthracyclines
, Common anthracycline antitumor abx: - ✔✔Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
The antitumor abx ___________ is not an anthracycline, but has anthracycline-type properties. -
✔✔Mitoxantrone
Common non-anthracycline antitumor abx: - ✔✔Actinomycin D
Mitomycin C
Bleomycin
Monitoring necessary with doxorubicin: - ✔✔Vesicant --> extravasation
Cardiac function
Lifetime dose tracking (cardiotoxicity)
Lifetime dose of doxorubicin should not exceed: - ✔✔550 mg/m^2
What cardiac protectant medication can be administered prior to doxorubicin? - ✔✔Dexrazoxane
Significant side effects of doxorubicin are: - ✔✔Cardiotoxicity
N/V
Mucositis
Diarrhea
Severe myelosuppression
Hepatic impairment
Secondary cancers
Monitoring necessary with bleomycin: - ✔✔Pulmonary toxicity
