GMS 6551 Final Exam Questions with Certified Solutions

GMS 6551 Final Exam Questions with Certified Solutions Which definition best describes a lead compound? The first compound discovered to have the desired activity. What method of discovering a drug is generally the least expensive? Molecular docking What is the name of the process that involves step-wise alteration of a drug to improve its properties? Structure activity relationship What was the estimated research and development expenses of pharma in 2016? 60 billion What branch of pharmacology studies the effect of the body on the drug? Pharmacokinetics What branch of pharmacology studies how patients respond differently to drugs? Pharmacogenetics What branch of pharmacology studies the desired effect of drugs on the body, usually at the molecular level? Pharmacodynamics What branch of pharmacology studies adverse effects of drugs on the body? Toxicology What branch of pharmacology does excretion fall under? Pharmacokinetics Which is the chemical name for a popular OTC painkiller? N-acetyl-para-aminophenol What is the proprietary name for a popular OTC painkiller? Tylenol Which is the non-proprietary name for a popular OTC painkiller? Acetaminophen Which of the following are OTC drugs in the U.S.? Select all that Apply Diphenhydramine (Benadryl) Loperamide (Diarrhea) 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol;hydrochloride (Nasal constriction) Which of the following are prescription drugs in the U.S.? Select all that apply. Codeine Levothyroxine (Hypothyroidism) Tadalafil (Erectile dysfunction) Sally receives a year-long prescription from her physician for low-dose codeine that allows for 11 refills. Her pharmacist will refuse to honor the full prescription because this is a schedule _____ controlled substance. III List four drugs containing the suffix -mab. What does the suffix denote? Sotrovimab Casirivimab Alemtuzumab Efalizumab -mab is nomenclature that identifies monoclonal antibodies. List one example drug each for the schedule 1- schedule V classifications. Schedule I- Rohypnol Schedule II- Amytal Schedule III- Bontril Schedule IV- Lunesta Schedule V- Lyrica Why do you think the FDA promotes orphan drugs? Less profits involved developing orphan drugs (drugs that treat rarer diseases) since the won't be used as often. More money in more popular drug development. A drug discovery program is only as good as its assay. WHY? If the assay is poor the drug discovery/ development process can not move forward. The assay process is when the drug is tested on its intended target to get a desired interaction. A good assay will help identify the drug target which then should lead way to identifying the lead compound. What inherent conflict does the legalization of