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NR 283: Pathophysiology Core
Assessment Final Exam
Comprehensive The Definitive Study
and Exam Prep Guide:
Comprehensive Topic Review,
Realistic Practice Questions,
Complete Test Bank Mastery, and
Advanced Preparation Manual
Question 11:
Question 1
A patient recovering from a lower-extremity injury asks which type of muscle tissue
is primarily responsible for moving the bones of the skeleton. Which response by the
nurse is most accurate?
A. Smooth, involuntary muscle
B. Cardiac, involuntary muscle
C. Striated, voluntary muscle
D. Non-striated, voluntary muscle
Correct Answer: C. Striated, voluntary muscle
Rationale:
Skeletal muscles are striated because their contractile proteins form visible bands, and
they are generally under voluntary control. They attach to bones and produce
movement across joints. Smooth muscle is non-striated and controls internal organs.
Cardiac muscle is striated but involuntary and is found only in the heart. Non-striated
voluntary muscle is not a recognized category.
Question 2
During an assessment of an older adult with osteoarthritis, the nurse observes firm,
painless enlargements at the distal interphalangeal joints. How should these findings
be documented?
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A. Bouchard nodes
B. Heberden nodes
C. Rheumatoid nodules
D. Gouty tophi
Correct Answer: B. Heberden nodes
Rationale:
Heberden nodes are bony enlargements of the distal interphalangeal joints associated
with osteoarthritis. Bouchard nodes affect the proximal interphalangeal joints.
Rheumatoid nodules are associated with rheumatoid arthritis and commonly occur
over pressure points. Gouty tophi consist of urate crystal deposits and may develop
around joints after prolonged hyperuricaemia.
Question 3
A postmenopausal patient sustains a vertebral compression fracture after bending to
lift a light object. Which underlying pathological change most likely contributed to
the fracture?
A. Excessive mineralisation of osteoid tissue
B. Loss of bone mass with increased porosity and brittleness
C. Deposition of uric acid crystals within the vertebrae
D. Autoimmune destruction of the articular cartilage
Correct Answer: B. Loss of bone mass with increased porosity and brittleness
Rationale:
Osteoporosis causes reduced bone mass and deterioration of bone architecture,
making bones porous, brittle, and vulnerable to low-trauma fractures. Excessive
mineralisation does not describe osteoporosis. Uric acid deposition causes gout, while
autoimmune joint destruction is characteristic of rheumatoid arthritis and primarily
affects synovial joints.
Question 4
Which patient has the greatest overall risk for developing osteoporosis?
A. A physically active premenopausal woman with adequate calcium intake
B. A large-framed woman with no family history of bone disease
C. A thin woman with early menopause and inadequate vitamin D intake
D. A young adult who performs weight-bearing exercise regularly
Correct Answer: C. A thin woman with early menopause and inadequate vitamin
D intake
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Rationale:
Early menopause reduces lifetime oestrogen exposure and can accelerate bone loss.
Low body mass and inadequate vitamin D further increase the risk of reduced bone
strength. Weight-bearing exercise and adequate calcium intake help protect bone
health, while a larger body frame is generally associated with greater bone mass.
Question 5
A patient with osteomalacia asks why the bones have become painful and weak.
Which explanation is most accurate?
A. Mature bone is being replaced by malignant cartilage cells.
B. Osteoid tissue is being produced but is inadequately mineralised.
C. Excess uric acid is eroding the bone surface.
D. Antibodies are destroying the synovial membranes.
Correct Answer: B. Osteoid tissue is being produced but is inadequately
mineralised.
Rationale:
Osteomalacia results from defective mineralisation of newly formed osteoid,
commonly associated with vitamin D deficiency or impaired vitamin D metabolism.
The bone matrix therefore remains soft and weak. Malignant cartilage cells describe
chondrosarcoma, uric acid deposition causes gout, and autoimmune synovial
inflammation is associated with rheumatoid arthritis.
Question 6
A patient with chronic bone pain has excessive bone resorption followed by
disorganised formation of enlarged, structurally weak bone. Which disorder should
the nurse suspect?
A. Paget disease
B. Osteomalacia
C. Osteomyelitis
D. Osteoarthritis
Correct Answer: A. Paget disease
Rationale:
Paget disease involves accelerated bone resorption followed by excessive and
disorganised bone formation. The resulting bone may become enlarged, deformed,
and mechanically weak. Osteomalacia involves defective mineralisation,
osteomyelitis is an infection of bone and marrow, and osteoarthritis primarily
involves degeneration of articular cartilage and subchondral bone.