Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1. (Chapter 1: The Practice of Medicine)
Which principle best defines evidence-based clinical practice?
A. Reliance on expert opinion
B. Integration of best research evidence with clinical expertise
and patient values
C. Use of standardized protocols only
D. Preference for pathophysiologic reasoning over data
Answer: B
Rationale: Harrison’s defines evidence-based practice as
combining high-quality evidence, clinician expertise, and
patient preferences to guide care.
,Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1
2. (Chapter 1)
Which nursing implication aligns with modern medical practice?
A. Avoid shared decision-making
B. Focus exclusively on disease treatment
C. Coordinate interprofessional care
D. Limit patient education to discharge
Answer: C
Rationale: Modern practice emphasizes team-based,
coordinated care to improve outcomes.
Citation: Harrison’s 22nd ed., Ch. 1
3. (Chapter 2: Promoting Good Health)
Which intervention has the greatest population-level impact on
morbidity reduction?
A. Advanced imaging
B. Lifestyle modification
C. Tertiary care services
D. Genetic testing
Answer: B
Rationale: Harrison’s highlights prevention and lifestyle changes
,as major determinants of health outcomes.
Citation: Harrison’s 22nd ed., Ch. 2
4. (Chapter 2)
Which nursing role is most critical in health promotion?
A. Ordering diagnostics
B. Counseling and behavior reinforcement
C. Prescribing medications
D. Performing invasive procedures
Answer: B
Rationale: Nurses are central to patient education and behavior
change reinforcement.
Citation: Harrison’s 22nd ed., Ch. 2
5. (Chapter 3: Vaccine Opposition and Hesitancy)
Which factor most strongly contributes to vaccine hesitancy?
A. Vaccine cost
B. Misinformation and distrust
C. Lack of provider access
D. Complex dosing schedules
Answer: B
Rationale: Harrison’s identifies misinformation and mistrust as
primary drivers of hesitancy.
Citation: Harrison’s 22nd ed., Ch. 3
, 6. (Chapter 3)
What nursing strategy best addresses vaccine hesitancy?
A. Dismiss patient concerns
B. Provide empathetic, evidence-based communication
C. Emphasize mandates only
D. Avoid discussion
Answer: B
Rationale: Respectful communication improves acceptance and
trust.
Citation: Harrison’s 22nd ed., Ch. 3
7. (Chapter 4: Decision-Making in Clinical Medicine)
Which model best reflects optimal clinical decision-making?
A. Algorithm-only approach
B. Clinician-driven decisions
C. Shared decision-making
D. Cost-driven decisions
Answer: C
Rationale: Harrison’s emphasizes shared decision-making
incorporating patient goals.
Citation: Harrison’s 22nd ed., Ch. 4
8. (Chapter 4)
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1. (Chapter 1: The Practice of Medicine)
Which principle best defines evidence-based clinical practice?
A. Reliance on expert opinion
B. Integration of best research evidence with clinical expertise
and patient values
C. Use of standardized protocols only
D. Preference for pathophysiologic reasoning over data
Answer: B
Rationale: Harrison’s defines evidence-based practice as
combining high-quality evidence, clinician expertise, and
patient preferences to guide care.
,Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1
2. (Chapter 1)
Which nursing implication aligns with modern medical practice?
A. Avoid shared decision-making
B. Focus exclusively on disease treatment
C. Coordinate interprofessional care
D. Limit patient education to discharge
Answer: C
Rationale: Modern practice emphasizes team-based,
coordinated care to improve outcomes.
Citation: Harrison’s 22nd ed., Ch. 1
3. (Chapter 2: Promoting Good Health)
Which intervention has the greatest population-level impact on
morbidity reduction?
A. Advanced imaging
B. Lifestyle modification
C. Tertiary care services
D. Genetic testing
Answer: B
Rationale: Harrison’s highlights prevention and lifestyle changes
,as major determinants of health outcomes.
Citation: Harrison’s 22nd ed., Ch. 2
4. (Chapter 2)
Which nursing role is most critical in health promotion?
A. Ordering diagnostics
B. Counseling and behavior reinforcement
C. Prescribing medications
D. Performing invasive procedures
Answer: B
Rationale: Nurses are central to patient education and behavior
change reinforcement.
Citation: Harrison’s 22nd ed., Ch. 2
5. (Chapter 3: Vaccine Opposition and Hesitancy)
Which factor most strongly contributes to vaccine hesitancy?
A. Vaccine cost
B. Misinformation and distrust
C. Lack of provider access
D. Complex dosing schedules
Answer: B
Rationale: Harrison’s identifies misinformation and mistrust as
primary drivers of hesitancy.
Citation: Harrison’s 22nd ed., Ch. 3
, 6. (Chapter 3)
What nursing strategy best addresses vaccine hesitancy?
A. Dismiss patient concerns
B. Provide empathetic, evidence-based communication
C. Emphasize mandates only
D. Avoid discussion
Answer: B
Rationale: Respectful communication improves acceptance and
trust.
Citation: Harrison’s 22nd ed., Ch. 3
7. (Chapter 4: Decision-Making in Clinical Medicine)
Which model best reflects optimal clinical decision-making?
A. Algorithm-only approach
B. Clinician-driven decisions
C. Shared decision-making
D. Cost-driven decisions
Answer: C
Rationale: Harrison’s emphasizes shared decision-making
incorporating patient goals.
Citation: Harrison’s 22nd ed., Ch. 4
8. (Chapter 4)
