Imperial College London (ICL)

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, cardiovascular and thoracic biology (CTB) module. CTB 8 on anaphylaxis: a not uncommon allergic, potentially life-threatening condition that involves both the respiratory and cardiovascular systems. learning objectives: LO1: List the cardinal signs of acute inflammation and anaphylaxis and describe the physiological mechanisms that bring these about. LO2: Summarise the progress of an immune response to an an...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, cardiovascular and thoracic biology (CTB) module. In this chapter, we are going to take a step into the future to see where current thinking about respiratory and cardiovascular diseases is heading, in particular thinking about where we may be in 10- 15 years’ time. It is a very exciting time for medical research in general, and including respiratory and cardiovascular research, with numerous new technologies ...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 9 on obesity: In this session, we will turn our attention to a different challenge: pharmaceuticals for treating obesity. We will start by defining what we mean by the term obese, before considering the fundamental causes, and pharmacologically-relevant mechanisms that contribute to obesity. Later, we will explore pharmaceuticals that are in use (or have previously been used) to treat o...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 9 on obesity: In this session, we will turn our attention to a different challenge: pharmaceuticals for treating obesity. We will start by defining what we mean by the term obese, before considering the fundamental causes, and pharmacologically-relevant mechanisms that contribute to obesity. Later, we will explore pharmaceuticals that are in use (or have previously been used) to treat o...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 9 on obesity: In this session, we will turn our attention to a different challenge: pharmaceuticals for treating obesity. We will start by defining what we mean by the term obese, before considering the fundamental causes, and pharmacologically-relevant mechanisms that contribute to obesity. Later, we will explore pharmaceuticals that are in use (or have previously been used) to treat o...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 1 module on introduction to pharmacology with pharmacodynamics: learning outcomes: - LO1 Pharmacodynamics: Define what is meant by a ‘drug’ and a ‘drug target site’. - LO2 Target sites: List the four main categories of drug target sites. - LO3 Selectivity: Explain the concept of drug selectivity (cf. specificity) and how this relates to ‘structure activity relationsh...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 2: introduction to pharmacology with pharmacokinetics. learning outcomes = - LO1 Administration: List the major routes by which drugs may be administered and their advantages and disadvantages. - LO2 Distribution: Identify the factors that affect the passage of drugs across membranes and thus determine drug distribution. - LO3 Metabolism: Identify the routes and biochemistry of Pha...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 4 on psychoactive drugs, stimulants (cocaine, nicotine): stimulate or increase the activity of nerves within the central nervous system - LO1: Administration: Predict how the route of administration of cocaine and nicotine will influence the speed of onset of central nervous system effects. - LO2: Metabolism: Explain how the metabolism of cocaine and nicotine contribute to their addict...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 3 on psychoactive drugs, depressants (alcohol, cannabis): - Lipid solubility: Predict how the lipid solubility of alcohol and cannabis will influence drug distribution. - Dosing: Calculate the amount of alcohol administered within specific doses and predict the likely bioavailability associated with each dose. - Pharmacokinetics: Compare and contrast how alcohol and cannabis are abso...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, Pharmacology module Pharmacology 8 on cancer drug therapies: In this session, we will refresh our memories about the hallmarks of cancer, before thinking about how some of those hallmarks might help us design and use pharmaceutical agents in therapy. We will be focusing on small-molecular chemotherapeutic agents, paying particular attention to their mechanism of action. learning outcomes: LO1: Provide a conci...