USMLE STEP 1 EXAM 2025/2026
QUESTIONS AND ANSWERS 100% PASS
Hormone to test for menopause. - ANS high FSH
Treatment of Heparin Induced Thrombocytopenia - ANS Direct thrombin inhibitors-
Agatroban
Then protamine sulfate
PT or PTT for Heparin - ANS PTT
PT or PTT for Warfarin - ANS PT
Skin necrosis from warfarin, what do you do? - ANS Give heparin
Antidote to excessive thrombolytics - ANS Aminocaproic acid
Glanzmanns Thrombasthenia - ANS GPIIb/IIIa- platelet adhesion
Bernard soulier - ANS Gp1b
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, Aspirin decreases platelet adehsion, activation or aggregation? - ANS Activation
Drugs that decrease platelet activation - ANS aspirin, toclopidine, clopidogrel- block ADP
receptors
Drugs that decrease aggregation - ANS abciximab, eptifibatide, tirofiban
Why do sulfonamides decrease increase PT in patients on warfarin? - ANS Sulfonamides
displace the weakly but extensively bound warfarin on plasma proteins. This is different
mechanism from cimetidine which increase P450
Onset, peak effect and duration of lispro - ANS onset: 0.3-0.5hrs
peak effect: 1-2 hrs
duration: 2-4hrs
Onset peak effect and duration of regular - ANS onset: 0.5-1hrs
peak effect: 2-4hrs
duration: 5-7hrs
Onset, peak effect and duration of glargine - ANS onset: 1hr
peak effect: no peak
duration>24hrs
What increases insulin release? what decreases insulin release - ANS 1. glucose, amino acids,
sulfonylureas, M-agonists, B2 agonists 2. a2 agonists
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
QUESTIONS AND ANSWERS 100% PASS
Hormone to test for menopause. - ANS high FSH
Treatment of Heparin Induced Thrombocytopenia - ANS Direct thrombin inhibitors-
Agatroban
Then protamine sulfate
PT or PTT for Heparin - ANS PTT
PT or PTT for Warfarin - ANS PT
Skin necrosis from warfarin, what do you do? - ANS Give heparin
Antidote to excessive thrombolytics - ANS Aminocaproic acid
Glanzmanns Thrombasthenia - ANS GPIIb/IIIa- platelet adhesion
Bernard soulier - ANS Gp1b
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, Aspirin decreases platelet adehsion, activation or aggregation? - ANS Activation
Drugs that decrease platelet activation - ANS aspirin, toclopidine, clopidogrel- block ADP
receptors
Drugs that decrease aggregation - ANS abciximab, eptifibatide, tirofiban
Why do sulfonamides decrease increase PT in patients on warfarin? - ANS Sulfonamides
displace the weakly but extensively bound warfarin on plasma proteins. This is different
mechanism from cimetidine which increase P450
Onset, peak effect and duration of lispro - ANS onset: 0.3-0.5hrs
peak effect: 1-2 hrs
duration: 2-4hrs
Onset peak effect and duration of regular - ANS onset: 0.5-1hrs
peak effect: 2-4hrs
duration: 5-7hrs
Onset, peak effect and duration of glargine - ANS onset: 1hr
peak effect: no peak
duration>24hrs
What increases insulin release? what decreases insulin release - ANS 1. glucose, amino acids,
sulfonylureas, M-agonists, B2 agonists 2. a2 agonists
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
