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Cholinesterase inhibitors - Answer: Donepezil
Rivastigmine
Galantamine
Neostigmine
Cholinesterase inhibitors side effects - Answer: dizziness, GI upset, fatigue, headache
Cholinesterase inhibitors adverse affects - Answer: bradycardia bronchoconstriction
Cholinesterase inhibitors interactions - Answer: Anticholinergics, first generation
anithistamines, TCA's, conventional antipsychotics
Donzepil side effects - Answer: nausea vomitting diarrhea urinary urgency
bronchoconstriction bradycardia orthostatic hypotension
Rivastigmine - Answer: side effects likely and more intense. Caution with PUD
bradycardia sick sinus syndrome urinary obstruction, lung disease. Transdermal route
lowers intensity of side effects.
Neostigmine - Answer: prevents acetylcholine degradation. Myasthenia gravis,
parkinsons dementia, alzheimers
Galantamine - Answer: caution use in asthma or copd . Avoid anticholinergics 1st gen
antihistamines, tcas, conventional antipsychotics because they reduce effects.
Nmda blocker - Answer: antagonist.
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, Memantime - Answer: NMDA blocker
Memantime adverse reactions - Answer: skin reactions. Steven johnsons syndrome.
Erythema multiforme. Bradycardia, hypertensions, angina.
Memantime side effects - Answer: dizziness headache confusion diarrhea or
constipation
Immunomodulators - Answer: interferon beta
Interferon beta - Answer: flu like symptoms, hepatotoxicity, myelosuppression
(decreases all blood cells monistor cbc frequently) injection site reaction. Depressions
Interferon beta drug interactions - Answer: other immunosuppressive drugs
Immunosuppressants - Answer: Mitoxantrone
Mitoxantrone - Answer: decreases autoimmune destruction of myelin.
Mitoxantrone side effects - Answer: myelosuppression(montior cbc) increased risk for
infections. No live virus immunizations. Cardiotoxicity (irreverisble damage to ejection
fraction) fetal harm (growth delay and prematurity)
Mitoxantrone reversible injuries - Answer: hair loss, Gi mucosa, amenorrhea,
sysmptoms of allergy, acute myelogenous leukemia.
Seizure meds - Answer: IV benzos (Diazepam/lorazepam
Longterm- phenytoin
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