Pharmacology 615 Practice Exam 2
WhatidrugirequiresiCBCimonitoringiandihowioftenishouldithisibeidone?i-iANSWERiCarbamazepine
ExplainiCarbamazepine'sihalf-lifei-iANSWERiWhenigiveniasiaisingleidose,itheihalf-
lifeiisi30ihours,ibutiwhenigivenicontinuouslyitheihalf-
lifeidecreasesitoi15ihoursibecauseithisidrugiisiaistrongiinduceriofihepaticienzymes
Whichimedicationiauto-inducesimetabolismi-iANSWERiCarbamazepine
Whatishouldifamiliesibeitaughtiregardingiseizuresi-
iANSWERiTeachifamiliesiaboutiprevention,ipatientisafety,iandiqualityiofilifeiissues.iMedicationsishouldino
tibeistoppediabruptlyiasithisicaniincreaseitheichanceiofiseizureiactivity
WhatielectrolyteiimbalanceiisinotediwithiTopiramatei(Topamax)i-
iANSWERiSerumiBicarbonateilevelsiareiaffected.
WhatiisitheipregnancyicategoryiforiValproatei(ValproiciAcid)i-
iANSWERiItiuseditoibeiCategoryiXibutitheiFDAidoesinotiuseitheseicategoriesianyimore.iThisimedicationish
ouldibeigivenionlyiafteritheifirstitrimester
Whatiinstructionsiwilliyouigiveitoiaiwomaniwhoiwantsitoigetipregnantiandiisitakingivalproateiforiseizureic
ontroli-
iANSWERiItiwouldibeirecommendedithatitheiwomaniswitchesitoianotherimedicationisuchiasiKeppraiatilea
stiuntiliafteritheifirstitrimester
WhyiareiTricycliciantidepressantsi(TCAs)iriskyi-
iANSWERiTheseiareiolderidrugs.iAlthoughitheyiareistilliusefuliinitreatingidepression,ithereiareimanyisideie
ffectsiandianioverdoseioniTCAsicanibeifatal
, WhatiareicommoniTCAisideieffectsi-
iANSWERidryimouth,isedation,iconstipation,iincreasediappetite,iblurredivision,itinnitus,ieuphoria,imania
ExplainitheicardiacieffectsiofiTCAi-
iANSWERiCardiaiconductionidisorderiisitheimostisignificantiriskiofiTCAs.iTCAsicanibehaveiasiantiarrhytmic
siandipossiblyiterminateiv-
fib,idecreaseicardiacicontractility,iandiincreaseicollateralibloodicirculationitoiischemiciheartimuscles
WhatiisiPhenelzinei(Nardil)i-
iANSWERiMonoamineiOxidaseiInhibitori(MAOI)iuseditoitreatirecalcitrantidepressioniasiwelliasiParkinson's
iandiseveraliotheridisorders
Whatiareitheiprecautionsiassociatediwithiphenelzinei(Nardil)i-
iANSWERiUsuallyireservediasilastiresortitreatmentidueitoirisks.iAvoidifoodsihighiinityramine.iTyramineiisif
oundiinifermentedifoods/drinksisuchiasialcohol,iwine,iandiagedicheeses.
Whatiisitheitimeiframeibetweenidiscontinuationiofiphenelzineianditheistartiofianotheritherapyi-
iANSWERi2iweeksishouldibeigivenisoithatiphenelzineiisifullyiclearedifromitheisystem
Whatiareitheis/sxiofihypertensiveicrisisi-
iANSWERiheadache,iheartipalpitations,istiffiorisoreineck,ichestitightness,itachycardia,isweating,idilatedip
upils
HowilongidoesiititakeiforiSSrRIsitoiproduceianieffectiforidepressionipatientsi-iANSWERi2-
6iweeks.imostiareiatifullieffectiwithini4iweeks
WheniisiBuspari(Buspirone)iandiandiSSRIicombinedi-
iANSWERiThisicombinationiisiusefuliforipatientsiwithiagitatediorianxiousidepression.iBuspariisihelpfuliinia
ugmentingitheiSSRI
WhatidrugirequiresiCBCimonitoringiandihowioftenishouldithisibeidone?i-iANSWERiCarbamazepine
ExplainiCarbamazepine'sihalf-lifei-iANSWERiWhenigiveniasiaisingleidose,itheihalf-
lifeiisi30ihours,ibutiwhenigivenicontinuouslyitheihalf-
lifeidecreasesitoi15ihoursibecauseithisidrugiisiaistrongiinduceriofihepaticienzymes
Whichimedicationiauto-inducesimetabolismi-iANSWERiCarbamazepine
Whatishouldifamiliesibeitaughtiregardingiseizuresi-
iANSWERiTeachifamiliesiaboutiprevention,ipatientisafety,iandiqualityiofilifeiissues.iMedicationsishouldino
tibeistoppediabruptlyiasithisicaniincreaseitheichanceiofiseizureiactivity
WhatielectrolyteiimbalanceiisinotediwithiTopiramatei(Topamax)i-
iANSWERiSerumiBicarbonateilevelsiareiaffected.
WhatiisitheipregnancyicategoryiforiValproatei(ValproiciAcid)i-
iANSWERiItiuseditoibeiCategoryiXibutitheiFDAidoesinotiuseitheseicategoriesianyimore.iThisimedicationish
ouldibeigivenionlyiafteritheifirstitrimester
Whatiinstructionsiwilliyouigiveitoiaiwomaniwhoiwantsitoigetipregnantiandiisitakingivalproateiforiseizureic
ontroli-
iANSWERiItiwouldibeirecommendedithatitheiwomaniswitchesitoianotherimedicationisuchiasiKeppraiatilea
stiuntiliafteritheifirstitrimester
WhyiareiTricycliciantidepressantsi(TCAs)iriskyi-
iANSWERiTheseiareiolderidrugs.iAlthoughitheyiareistilliusefuliinitreatingidepression,ithereiareimanyisideie
ffectsiandianioverdoseioniTCAsicanibeifatal
, WhatiareicommoniTCAisideieffectsi-
iANSWERidryimouth,isedation,iconstipation,iincreasediappetite,iblurredivision,itinnitus,ieuphoria,imania
ExplainitheicardiacieffectsiofiTCAi-
iANSWERiCardiaiconductionidisorderiisitheimostisignificantiriskiofiTCAs.iTCAsicanibehaveiasiantiarrhytmic
siandipossiblyiterminateiv-
fib,idecreaseicardiacicontractility,iandiincreaseicollateralibloodicirculationitoiischemiciheartimuscles
WhatiisiPhenelzinei(Nardil)i-
iANSWERiMonoamineiOxidaseiInhibitori(MAOI)iuseditoitreatirecalcitrantidepressioniasiwelliasiParkinson's
iandiseveraliotheridisorders
Whatiareitheiprecautionsiassociatediwithiphenelzinei(Nardil)i-
iANSWERiUsuallyireservediasilastiresortitreatmentidueitoirisks.iAvoidifoodsihighiinityramine.iTyramineiisif
oundiinifermentedifoods/drinksisuchiasialcohol,iwine,iandiagedicheeses.
Whatiisitheitimeiframeibetweenidiscontinuationiofiphenelzineianditheistartiofianotheritherapyi-
iANSWERi2iweeksishouldibeigivenisoithatiphenelzineiisifullyiclearedifromitheisystem
Whatiareitheis/sxiofihypertensiveicrisisi-
iANSWERiheadache,iheartipalpitations,istiffiorisoreineck,ichestitightness,itachycardia,isweating,idilatedip
upils
HowilongidoesiititakeiforiSSrRIsitoiproduceianieffectiforidepressionipatientsi-iANSWERi2-
6iweeks.imostiareiatifullieffectiwithini4iweeks
WheniisiBuspari(Buspirone)iandiandiSSRIicombinedi-
iANSWERiThisicombinationiisiusefuliforipatientsiwithiagitatediorianxiousidepression.iBuspariisihelpfuliinia
ugmentingitheiSSRI
