PCB 3233 Immunology Exam 4
Positive Selection - correct answer ✔✔makes sure that your T-Cell recognizes one of your MHC.
If it does not, then apoptosis
Negative Selection - correct answer ✔✔Makes sure it does not recognize your peptide:MHC too strongly
Does gamma: delta T-cells have to go through positive selection? - correct answer ✔✔No
What does turning off RAG 1&2 do to your gene rearrangement? - correct answer ✔✔Preserve the
current rearrangement
Primary Lymphoid Tissue - correct answer ✔✔bone marrow and thymus
What does TH1 cells do? - correct answer ✔✔Activate macrophages
Thymal Stromal Cells - correct answer ✔✔Keeps BCR genes closed and opens TCR genes
IgM activates? - correct answer ✔✔complement
Notch-1 - correct answer ✔✔The signal for survival. It drives the cell on the T-cell path — signals to open
up T-cell rearrangement.
Signaling rearrangement keeps T-cel on T-cell pathway
Where does Maturation and Positive Selection occur? - correct answer ✔✔Cortex of the thymus
,Can negative selection also take place in the Cortex? - correct answer ✔✔Yes, negative selection can
take place in the cortex at the same time as positive selection
Where does negative selection take place? - correct answer ✔✔medulla of thymus
Where are mature thymocytes located? - correct answer ✔✔Medulla
Where are immature thymocytes located? - correct answer ✔✔Cortex
What special cells are in the Medulla - correct answer ✔✔Dendritic cells, macrophages, and medullary
epithelial cells
What special cells are in the cortex? - correct answer ✔✔Cortical epithelial cells and macrophages
Where can you find AIRE? - correct answer ✔✔in the medullary epithelial cells
AIRE - correct answer ✔✔Autoimmune regulator
made by medullary epithelial cells
Creates a couple hundred peripheral peptides that can be used to test T-cells for negative selection
DiGeorge's syndrome - correct answer ✔✔deletion in chromosome 22 in which thymus fails to develop
and T-cells are absent
Hassall's corpuscles - correct answer ✔✔macrophages in both cortex and medulla remove the many
thymocytes that fail to mature properly
Involution of the Thymus - correct answer ✔✔Progressively shrinks, fat gradually claiming areas once
packed with thymocytes
, -reduces production of new T-cells
Double negative - correct answer ✔✔No CD4 and CD8
Double Positive - correct answer ✔✔CD4 and CD8 are present
Single Positive - correct answer ✔✔has either CD4 or CD8
CD2 and CD5 - correct answer ✔✔perform adhesion and signaling. They are present during double
negative stage
Thymocytes rearrange which 3 genes at the same time? - correct answer ✔✔Beta, gamma, and delta
pTalpha - correct answer ✔✔surrogate alpha chain. signals cell to halt gamma, delta, Beta chains, gene
rearrangement and begin proliferation.
What do macrophages do in the thymus? - correct answer ✔✔continually remove dead cells
How many rearrangements can successfully make a Beta chain? - correct answer ✔✔up to 4 attempts
d:k light chain can have a minimum of how many rearrangements? - correct answer ✔✔4 minimum
attempts
alpha chain allows many successive rearrangements with a minimum of - correct answer ✔✔2 attempts
What is the first checkpoint in T-cell maturation? - correct answer ✔✔Pre-TCR
Checking beta chain is a productive rearrangement
Positive Selection - correct answer ✔✔makes sure that your T-Cell recognizes one of your MHC.
If it does not, then apoptosis
Negative Selection - correct answer ✔✔Makes sure it does not recognize your peptide:MHC too strongly
Does gamma: delta T-cells have to go through positive selection? - correct answer ✔✔No
What does turning off RAG 1&2 do to your gene rearrangement? - correct answer ✔✔Preserve the
current rearrangement
Primary Lymphoid Tissue - correct answer ✔✔bone marrow and thymus
What does TH1 cells do? - correct answer ✔✔Activate macrophages
Thymal Stromal Cells - correct answer ✔✔Keeps BCR genes closed and opens TCR genes
IgM activates? - correct answer ✔✔complement
Notch-1 - correct answer ✔✔The signal for survival. It drives the cell on the T-cell path — signals to open
up T-cell rearrangement.
Signaling rearrangement keeps T-cel on T-cell pathway
Where does Maturation and Positive Selection occur? - correct answer ✔✔Cortex of the thymus
,Can negative selection also take place in the Cortex? - correct answer ✔✔Yes, negative selection can
take place in the cortex at the same time as positive selection
Where does negative selection take place? - correct answer ✔✔medulla of thymus
Where are mature thymocytes located? - correct answer ✔✔Medulla
Where are immature thymocytes located? - correct answer ✔✔Cortex
What special cells are in the Medulla - correct answer ✔✔Dendritic cells, macrophages, and medullary
epithelial cells
What special cells are in the cortex? - correct answer ✔✔Cortical epithelial cells and macrophages
Where can you find AIRE? - correct answer ✔✔in the medullary epithelial cells
AIRE - correct answer ✔✔Autoimmune regulator
made by medullary epithelial cells
Creates a couple hundred peripheral peptides that can be used to test T-cells for negative selection
DiGeorge's syndrome - correct answer ✔✔deletion in chromosome 22 in which thymus fails to develop
and T-cells are absent
Hassall's corpuscles - correct answer ✔✔macrophages in both cortex and medulla remove the many
thymocytes that fail to mature properly
Involution of the Thymus - correct answer ✔✔Progressively shrinks, fat gradually claiming areas once
packed with thymocytes
, -reduces production of new T-cells
Double negative - correct answer ✔✔No CD4 and CD8
Double Positive - correct answer ✔✔CD4 and CD8 are present
Single Positive - correct answer ✔✔has either CD4 or CD8
CD2 and CD5 - correct answer ✔✔perform adhesion and signaling. They are present during double
negative stage
Thymocytes rearrange which 3 genes at the same time? - correct answer ✔✔Beta, gamma, and delta
pTalpha - correct answer ✔✔surrogate alpha chain. signals cell to halt gamma, delta, Beta chains, gene
rearrangement and begin proliferation.
What do macrophages do in the thymus? - correct answer ✔✔continually remove dead cells
How many rearrangements can successfully make a Beta chain? - correct answer ✔✔up to 4 attempts
d:k light chain can have a minimum of how many rearrangements? - correct answer ✔✔4 minimum
attempts
alpha chain allows many successive rearrangements with a minimum of - correct answer ✔✔2 attempts
What is the first checkpoint in T-cell maturation? - correct answer ✔✔Pre-TCR
Checking beta chain is a productive rearrangement
