NURS 6630 Psychopharmacology Midterm
Study Guide| 100% Verified Solutions|
Walden University
Serotonin regulates
Mood, emotion, feeding, and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from
reuptake of serotonin to increase levels in the synaptic cleft to bind with
postsynaptic 5HT2 receptors
SSRIs
First line therapy for MDD due to milder side effect profiles
SSRIs
Six Common SSRIs
citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline, paroxetine
,Onset of therapeutic benefit from SSRIs
4-6 weeks
In addition to MDD, SSRIs also treat
Chronic Anxiety, PTSD, OCD, and eating disorders (bulimia)
Five Common side effects of SSRIs include
Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old
suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in combination with
other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.)
Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the nervous
system
Serotonin Syndrome
,Seven symptoms of Serotonin Syndrome
Flushing, hyperthermia, agitation, muscle rigidity, seizure, coma, Hyperreflexia
The treatment for serotonin syndrome
Cyproheptadine (5-HT2 receptor antagonist)
Cyproheptadine treats serotonin syndrome by
blocking 5-HT2 receptors (serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal
include
Irritability, headaches, and insomnia
Medicine specific side effect of citalopram
Prolonged QT interval (normal=0.4.-0.44 seconds)
, This SSRI is pregnancy category D due to associations with congenital heart
defects
Paroxetine
All SSRIs but paroxetine (D) are pregnancy category
C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes
fluoxetine, fluvoxamine, and paroxetine
Five common SNRIs include
duloxetine, venlafaxine, desvenlafaxine, milnacipran, Levomilnacipran
This antidepressant class of medications works by binding to presynaptic SERT and
NET to inhibit them from reuptake of serotonin and norepinephrine to increase
their levels in the synaptic cleft
SNRIs
In addition to MDD SNRIs treat
Study Guide| 100% Verified Solutions|
Walden University
Serotonin regulates
Mood, emotion, feeding, and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from
reuptake of serotonin to increase levels in the synaptic cleft to bind with
postsynaptic 5HT2 receptors
SSRIs
First line therapy for MDD due to milder side effect profiles
SSRIs
Six Common SSRIs
citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline, paroxetine
,Onset of therapeutic benefit from SSRIs
4-6 weeks
In addition to MDD, SSRIs also treat
Chronic Anxiety, PTSD, OCD, and eating disorders (bulimia)
Five Common side effects of SSRIs include
Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old
suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in combination with
other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.)
Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the nervous
system
Serotonin Syndrome
,Seven symptoms of Serotonin Syndrome
Flushing, hyperthermia, agitation, muscle rigidity, seizure, coma, Hyperreflexia
The treatment for serotonin syndrome
Cyproheptadine (5-HT2 receptor antagonist)
Cyproheptadine treats serotonin syndrome by
blocking 5-HT2 receptors (serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal
include
Irritability, headaches, and insomnia
Medicine specific side effect of citalopram
Prolonged QT interval (normal=0.4.-0.44 seconds)
, This SSRI is pregnancy category D due to associations with congenital heart
defects
Paroxetine
All SSRIs but paroxetine (D) are pregnancy category
C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes
fluoxetine, fluvoxamine, and paroxetine
Five common SNRIs include
duloxetine, venlafaxine, desvenlafaxine, milnacipran, Levomilnacipran
This antidepressant class of medications works by binding to presynaptic SERT and
NET to inhibit them from reuptake of serotonin and norepinephrine to increase
their levels in the synaptic cleft
SNRIs
In addition to MDD SNRIs treat
