IFM Review Course with all Correct & 100% Verified
Answers |Latest Update |Already Graded A+
Non-heme iron sources of food should be pair with ____ to help enhance absorption ✔Correct
Answer--Vitamin C rich foods
what are clinical signs of Zinc deficiency? ✔Correct Answer--dermatitis, hair loss, frequent
infection, glossitis, nail dystrophy
Low Zinc is paired with what on labs? ✔Correct Answer--high copper, low Alk phos
Jaundice after fasting is most indicative of a genetic weakness in which biotransformation pathway?
✔Correct Answer--glucuronidation
Gilberts is a SNP in what? ✔Correct Answer--UGT 1a — impairs gluruonidation
Cigarette smoking induces what CYP enzyme? ✔Correct Answer--CYP1a2
Which mineral is a cofactor for ALL CYP p450 enzymes ✔Correct Answer--iron
What are the types of phase 1 reactions ✔Correct Answer--Oxidation, reduction, hydrolysis,
lipolysis
What are the types of phase 2 reactions ✔Correct Answer--Glutathione conjunction, AA
conjugation, methylation, sulfating, acetylation, glucuronidation
Which CYP enzyme metabolizes 40-45% of drugs & hormones ✔Correct Answer--3A4
Which phase 1 enzyme metabolizes 4-oh ✔Correct Answer--1B1
Which enzyme metabolizes caffeine ✔Correct Answer--CYP 1A2
What does Gilbert's syndrome patients have an impaired ability to do? ✔Correct Answer--
Conjugate bilirubin with glucuronidation
Which mineral is a required co-factor for all CYP enzymes> ✔Correct Answer--Iron
__ deficiency is seen with: dermatitis, hair loss, frequent infection, glossitis ✔Correct Answer--Zinc
What types of patients cases have sulfation issues? ✔Correct Answer--Chemical sensitivity,
Alzheimer's, Parkinson's, RA, delayed food sensitivity, diet responsive autism, Tylenol intolerance.
High levels of CYPa12 activity are associated with ? In smokers ✔Correct Answer--Colon cancers
What SNP does Gilbert's have? ✔Correct Answer--UGT1a
Non-heme iron needs ? To enhance absorption ✔Correct Answer--Vitamin c
What meds should Gilberts syndrome avoid? ✔Correct Answer--acetaminophen
,What are some signs of poor glucuronidation? ✔Correct Answer--Dysbiosis, high Beta-
glucuronidase
How can you look for sulfonation issues? ✔Correct Answer--Sulfur AA: methionine, cystathionine,
cysteine
What does glucuronidation work on? ✔Correct Answer--Bilirubin, steroid/thyroid hormones,
prostaglandins, bile acids and lipophilic xenobiotics
How do we support sulfation? ✔Correct Answer--High sulfur foods (seafood). Sulfur AA
(methionine, NAC, Taurine), MSM
Loss of vibratory sense can be seen with what phase 2 issue? ✔Correct Answer--Methylation
What are some labs to check for low glutathione ✔Correct Answer--RBC glutathione, blood
glutathione peroxidase, serum/plasma cysteine and urine mercapturic acid (would be low)
___ deficiency is seen with: pale tongue, cheek, conjunctiva, angular stomatitis, glossitis, fingernails
ridging/brittle/spoon shaped, pale nail beds ✔Correct Answer--Iron
What are supportive nutrients for glucuronidation? ✔Correct Answer--Ca D-glucarate, quercetin,
probiotics, EFAs, Mg
What is low alk phos seen with? ✔Correct Answer--Zinc deficiency
What inhibits the absorption of iron? ✔Correct Answer--Phytic acid
What are some beta-glucuronidase inhibitors? ✔Correct Answer--Calcium D-glucarate, silymarin,
black currant, reishi, DGL, probiotics, prebiotic foods (inulin)
What amino acids are the main ones for AA conjugation ✔Correct Answer--Glycine, taurine,
arginine, glutamine
What nutrients are needed for methylation support ✔Correct Answer--Methionine, B12 B6,
betaine, folate, Mg
What does someone with SULT gene SNP have issues with ✔Correct Answer--Phase 2 sulfation
What does acetylation eliminate? ✔Correct Answer--Histamine, serotonin, sulfa drugs
For what types of conditions should we use Detox food plan? ✔Correct Answer--High LFTs,
dysbiosis, fatigue, leaky gut, asthma/allergies
What supports glutathione? ✔Correct Answer--NAC, glycine, lipoic acid, methyB12/folate, high
fruit/veg/nut intake
What are chemoprotective phytonutrients for prostate cancer? ✔Correct Answer--Polyphenols:
(lycopene, pomegranate juice, lignans), sulforaphane
, What nutrients are needed for glutathione support ✔Correct Answer--B6, Mg, selenium,
methionine, cysteine, glycine, folate, ALA
What are some lab measures of antioxidant capacity? ✔Correct Answer--Whole blood
GSH ,glutathione peroxidase, superoxide dismutase, CoQ10 (plasma)
What does AA conjugation help detox? ✔Correct Answer--Bile acids, branched chain fatty acids,
ibuprofen (taurine), salicylic acid (glycine), depakote
What nutrients enhance acetylation? ✔Correct Answer--Pantothenic acid, Vit C, B1, B2, Mg and
lipoate
What xenobiotics/toxins are related to serum GGT? ✔Correct Answer--Lead, cadmium, dioxins,
Organochlorate pesticides
What are chemoprotective phytonutrients for breast cancer? ✔Correct Answer--EGCG, polypheon-
rich diet (quercetin, luteolin, resvertrol, curcuminoids), organosulfur compounds, mediterranean
type diet (>5F/V, legumes, EVOO)
What effect does fasting have on biotransformation? ✔Correct Answer--Decreased sulfonate
conjugation and glucuronidation (phase 2 reactions re nutrient dependent)
What nutrient is glutathione peroxidase dependent on? ✔Correct Answer--Selenium
What are some phytochelators to help eliminate estrogen? ✔Correct Answer--Inulin (dec B-
glucuronidase), wheat bran and Senna (lower estrogen concentrations)
What else do Amino acids do? ✔Correct Answer--Utilized as neurotransmitters in CNS
How does garlic help with detox? ✔Correct Answer--Increases glutathione
What are examples of bi-functioanl phytochemical modulators (works on phase 1 & 2) ✔Correct
Answer--Pomegranate, turmeric, green tea, cruciferous veggies, beet, garlic
What is glutathione made of? ✔Correct Answer--Glutamate, cysteine, glycine
How does green tea work for detox? ✔Correct Answer--"Phase 1: inhibits over-induction of P450
enzymes
Phase 2: enhances induction of glutathione S-transferase and quinone reductase"
what effects does increased estrogen have on liver? ✔Correct Answer--increases: SHBG,
corticosteroid binding globulin, thyroid binding globulin, cerulopasmin, HDL cholesterol,
Phase 2 biotransformation conjugates reactive intermediates from phase 1 and makes them less
____philic and more___philic ✔Correct Answer--Lipophilic. hydrophilic.
What does PURE stand for ✔Correct Answer--Patter recognition, undernourished, reduce
exposures, ensure safe detox
How does pomegranate work for detox? ✔Correct Answer--Contains Ellagic acid which binds to
DNA and protects against carcinogens
Answers |Latest Update |Already Graded A+
Non-heme iron sources of food should be pair with ____ to help enhance absorption ✔Correct
Answer--Vitamin C rich foods
what are clinical signs of Zinc deficiency? ✔Correct Answer--dermatitis, hair loss, frequent
infection, glossitis, nail dystrophy
Low Zinc is paired with what on labs? ✔Correct Answer--high copper, low Alk phos
Jaundice after fasting is most indicative of a genetic weakness in which biotransformation pathway?
✔Correct Answer--glucuronidation
Gilberts is a SNP in what? ✔Correct Answer--UGT 1a — impairs gluruonidation
Cigarette smoking induces what CYP enzyme? ✔Correct Answer--CYP1a2
Which mineral is a cofactor for ALL CYP p450 enzymes ✔Correct Answer--iron
What are the types of phase 1 reactions ✔Correct Answer--Oxidation, reduction, hydrolysis,
lipolysis
What are the types of phase 2 reactions ✔Correct Answer--Glutathione conjunction, AA
conjugation, methylation, sulfating, acetylation, glucuronidation
Which CYP enzyme metabolizes 40-45% of drugs & hormones ✔Correct Answer--3A4
Which phase 1 enzyme metabolizes 4-oh ✔Correct Answer--1B1
Which enzyme metabolizes caffeine ✔Correct Answer--CYP 1A2
What does Gilbert's syndrome patients have an impaired ability to do? ✔Correct Answer--
Conjugate bilirubin with glucuronidation
Which mineral is a required co-factor for all CYP enzymes> ✔Correct Answer--Iron
__ deficiency is seen with: dermatitis, hair loss, frequent infection, glossitis ✔Correct Answer--Zinc
What types of patients cases have sulfation issues? ✔Correct Answer--Chemical sensitivity,
Alzheimer's, Parkinson's, RA, delayed food sensitivity, diet responsive autism, Tylenol intolerance.
High levels of CYPa12 activity are associated with ? In smokers ✔Correct Answer--Colon cancers
What SNP does Gilbert's have? ✔Correct Answer--UGT1a
Non-heme iron needs ? To enhance absorption ✔Correct Answer--Vitamin c
What meds should Gilberts syndrome avoid? ✔Correct Answer--acetaminophen
,What are some signs of poor glucuronidation? ✔Correct Answer--Dysbiosis, high Beta-
glucuronidase
How can you look for sulfonation issues? ✔Correct Answer--Sulfur AA: methionine, cystathionine,
cysteine
What does glucuronidation work on? ✔Correct Answer--Bilirubin, steroid/thyroid hormones,
prostaglandins, bile acids and lipophilic xenobiotics
How do we support sulfation? ✔Correct Answer--High sulfur foods (seafood). Sulfur AA
(methionine, NAC, Taurine), MSM
Loss of vibratory sense can be seen with what phase 2 issue? ✔Correct Answer--Methylation
What are some labs to check for low glutathione ✔Correct Answer--RBC glutathione, blood
glutathione peroxidase, serum/plasma cysteine and urine mercapturic acid (would be low)
___ deficiency is seen with: pale tongue, cheek, conjunctiva, angular stomatitis, glossitis, fingernails
ridging/brittle/spoon shaped, pale nail beds ✔Correct Answer--Iron
What are supportive nutrients for glucuronidation? ✔Correct Answer--Ca D-glucarate, quercetin,
probiotics, EFAs, Mg
What is low alk phos seen with? ✔Correct Answer--Zinc deficiency
What inhibits the absorption of iron? ✔Correct Answer--Phytic acid
What are some beta-glucuronidase inhibitors? ✔Correct Answer--Calcium D-glucarate, silymarin,
black currant, reishi, DGL, probiotics, prebiotic foods (inulin)
What amino acids are the main ones for AA conjugation ✔Correct Answer--Glycine, taurine,
arginine, glutamine
What nutrients are needed for methylation support ✔Correct Answer--Methionine, B12 B6,
betaine, folate, Mg
What does someone with SULT gene SNP have issues with ✔Correct Answer--Phase 2 sulfation
What does acetylation eliminate? ✔Correct Answer--Histamine, serotonin, sulfa drugs
For what types of conditions should we use Detox food plan? ✔Correct Answer--High LFTs,
dysbiosis, fatigue, leaky gut, asthma/allergies
What supports glutathione? ✔Correct Answer--NAC, glycine, lipoic acid, methyB12/folate, high
fruit/veg/nut intake
What are chemoprotective phytonutrients for prostate cancer? ✔Correct Answer--Polyphenols:
(lycopene, pomegranate juice, lignans), sulforaphane
, What nutrients are needed for glutathione support ✔Correct Answer--B6, Mg, selenium,
methionine, cysteine, glycine, folate, ALA
What are some lab measures of antioxidant capacity? ✔Correct Answer--Whole blood
GSH ,glutathione peroxidase, superoxide dismutase, CoQ10 (plasma)
What does AA conjugation help detox? ✔Correct Answer--Bile acids, branched chain fatty acids,
ibuprofen (taurine), salicylic acid (glycine), depakote
What nutrients enhance acetylation? ✔Correct Answer--Pantothenic acid, Vit C, B1, B2, Mg and
lipoate
What xenobiotics/toxins are related to serum GGT? ✔Correct Answer--Lead, cadmium, dioxins,
Organochlorate pesticides
What are chemoprotective phytonutrients for breast cancer? ✔Correct Answer--EGCG, polypheon-
rich diet (quercetin, luteolin, resvertrol, curcuminoids), organosulfur compounds, mediterranean
type diet (>5F/V, legumes, EVOO)
What effect does fasting have on biotransformation? ✔Correct Answer--Decreased sulfonate
conjugation and glucuronidation (phase 2 reactions re nutrient dependent)
What nutrient is glutathione peroxidase dependent on? ✔Correct Answer--Selenium
What are some phytochelators to help eliminate estrogen? ✔Correct Answer--Inulin (dec B-
glucuronidase), wheat bran and Senna (lower estrogen concentrations)
What else do Amino acids do? ✔Correct Answer--Utilized as neurotransmitters in CNS
How does garlic help with detox? ✔Correct Answer--Increases glutathione
What are examples of bi-functioanl phytochemical modulators (works on phase 1 & 2) ✔Correct
Answer--Pomegranate, turmeric, green tea, cruciferous veggies, beet, garlic
What is glutathione made of? ✔Correct Answer--Glutamate, cysteine, glycine
How does green tea work for detox? ✔Correct Answer--"Phase 1: inhibits over-induction of P450
enzymes
Phase 2: enhances induction of glutathione S-transferase and quinone reductase"
what effects does increased estrogen have on liver? ✔Correct Answer--increases: SHBG,
corticosteroid binding globulin, thyroid binding globulin, cerulopasmin, HDL cholesterol,
Phase 2 biotransformation conjugates reactive intermediates from phase 1 and makes them less
____philic and more___philic ✔Correct Answer--Lipophilic. hydrophilic.
What does PURE stand for ✔Correct Answer--Patter recognition, undernourished, reduce
exposures, ensure safe detox
How does pomegranate work for detox? ✔Correct Answer--Contains Ellagic acid which binds to
DNA and protects against carcinogens
