Lisdexamfetamine amphetamines (adverse effects)
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i. CNS stimulation.
ii. Weight loss.
iii. Cardiovascular effects.
iv. Psychosis.
Interferon-beta therapy (Multiple Sclerosis)
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, i. Multiple Sclerosis
ii. Immunomodulators
1. How it works:
a) Reduces severity and frequency of attacks.
b) Reduces development of brain lesions detectable by magnetic
resonance imaging (MRI).
c) Delays progression of disease.
2. Naturally occurring glycoprotein with antiviral, antiproliferative, and
immunomodulatory actions.
3. Immunosuppressive quality.
a) Inhibits WBC
b) Inhibits T-helper cells
4. Does not prevent or cause infection but can make an infection worse.
5. May cause FLU-LIKE symptoms, not actually cause the flu.
6. Injection reactions
a) No warm or cold compress.
i. Do not change the temperature of the tissue.
b) Benadryl if needed c) Hydrocortisone cream if needed.
d) Rotate injection sites to avoid injection site reactions and skin break
down.
7. Can cause depression and suicidal thoughts.
8. Allow 48 hours between injections.
9. Start with low dose then increase too more.
Neuroleptics (what it does, and what to know)
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i. Block antiemetic action.
ii. First generation (typical) antipsychotics. 1. Block receptors for dopamine
in the striatum and decrease therapeutic effects of levodopa.
EPS (strategies and treatments)
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, i. Strategies
1. Stop the causing agent immediately.
ii. Treatments
1. Benzodiazepines
2. Beta blockers
3. Anticholinergic drugs
Lisdexamfetamine adverse effects (amphetamines)
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1. Pharmacologic effects
a) CNS.
b) Cardiovascular system.
2. Bronchospasm side effects
3. Tolerance
a) With regular use, tolerance develops to elevation of mood, suppression
of appetite, and stimulation of the heart and blood vessels.
4. Physical dependence.
a) Abstinence syndrome with abrupt withdrawal.
5. Abuse.
a) High potential for abuse due to euphoric effect.
Lithium therapy (toxicity levels, side effect and adverse effects at therapeutic level,
and teaching)
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g. Toxicity levels
i. 1.5 mEq/L and above. ii. Lithium excretion will be reduced with decreased
sodium, if kidneys are not excreting the lithium properly, toxicity will occur.
Therefore, kidney functions need to be tested frequently. h. Side
effects/Adverse effects at therapeutic level
, i. Leukocytes increased, tremors, hypothyroidism and goiter, increased
urine, moms beware (teratogenesis).
ii. GI effects.
iii. Renal toxicity.
i. Teaching
i. Interacts with diuretics, NSAIDs, anticholinergic drugs
TID
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three times a day
Cholinesterase inhibitors (indications)
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b. Indications.
i. Mild to moderate AD
Amitriptyline (Drug/Drug interactions)
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i. CNS stimulation.
ii. Weight loss.
iii. Cardiovascular effects.
iv. Psychosis.
Interferon-beta therapy (Multiple Sclerosis)
Give this one a try later!
, i. Multiple Sclerosis
ii. Immunomodulators
1. How it works:
a) Reduces severity and frequency of attacks.
b) Reduces development of brain lesions detectable by magnetic
resonance imaging (MRI).
c) Delays progression of disease.
2. Naturally occurring glycoprotein with antiviral, antiproliferative, and
immunomodulatory actions.
3. Immunosuppressive quality.
a) Inhibits WBC
b) Inhibits T-helper cells
4. Does not prevent or cause infection but can make an infection worse.
5. May cause FLU-LIKE symptoms, not actually cause the flu.
6. Injection reactions
a) No warm or cold compress.
i. Do not change the temperature of the tissue.
b) Benadryl if needed c) Hydrocortisone cream if needed.
d) Rotate injection sites to avoid injection site reactions and skin break
down.
7. Can cause depression and suicidal thoughts.
8. Allow 48 hours between injections.
9. Start with low dose then increase too more.
Neuroleptics (what it does, and what to know)
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i. Block antiemetic action.
ii. First generation (typical) antipsychotics. 1. Block receptors for dopamine
in the striatum and decrease therapeutic effects of levodopa.
EPS (strategies and treatments)
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, i. Strategies
1. Stop the causing agent immediately.
ii. Treatments
1. Benzodiazepines
2. Beta blockers
3. Anticholinergic drugs
Lisdexamfetamine adverse effects (amphetamines)
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1. Pharmacologic effects
a) CNS.
b) Cardiovascular system.
2. Bronchospasm side effects
3. Tolerance
a) With regular use, tolerance develops to elevation of mood, suppression
of appetite, and stimulation of the heart and blood vessels.
4. Physical dependence.
a) Abstinence syndrome with abrupt withdrawal.
5. Abuse.
a) High potential for abuse due to euphoric effect.
Lithium therapy (toxicity levels, side effect and adverse effects at therapeutic level,
and teaching)
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g. Toxicity levels
i. 1.5 mEq/L and above. ii. Lithium excretion will be reduced with decreased
sodium, if kidneys are not excreting the lithium properly, toxicity will occur.
Therefore, kidney functions need to be tested frequently. h. Side
effects/Adverse effects at therapeutic level
, i. Leukocytes increased, tremors, hypothyroidism and goiter, increased
urine, moms beware (teratogenesis).
ii. GI effects.
iii. Renal toxicity.
i. Teaching
i. Interacts with diuretics, NSAIDs, anticholinergic drugs
TID
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three times a day
Cholinesterase inhibitors (indications)
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b. Indications.
i. Mild to moderate AD
Amitriptyline (Drug/Drug interactions)
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