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Examen
Intermediate filaments: new proteins, some answers, more questions
At this point, I would like briefly to draw attention to an intriguing and rather heterodox proposal, made by Lai et al. [61"]. Vimentin is a major cellular phosphoprotein and its level of phosphorylation changes during the cell cycle. Aside from a likely role in the disruption of vimentin filaments in the region of the contractile ring during cytokinesis (see [62,63]), the physiological significance ofvimentin phosphorylation remains unclear. On the basis of a study of four diffe...
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Examen
Intermediate filaments: new proteins, some answers, more questions
PopularA second group, the neuronal clFps, are related more in terms of intron/exon structure than primary se- quence. This group contains the rather divergent clF proteins NF1, NFm, NFh, 0t-internexin and nestin. It appears that these proteins can all co-polymerize with vimentin and, from the point of view of IF network formation, may be viewed as partners of vimentin. There is, however, a clear-cut distinction between the [-352 amino acid central s-helical domain Nuclear lamins -I N...
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