N191 - DMARD's Exam with Correct Answers
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Terms in this set (17)
are a group of medications commonly used in people
with
rheumatoid arthritis
What are DMARD's? also used in psoriatic arthritis, ankylosing spondylitis,
and systemic lupus erythematosus
For autoimmune things, body attacks itself so the
drugs suppress immune system
decrease pain and inflammation
What do DMARD's work reduce or prevent joint damage - slows joint
to do? degradation
preserve the structure and function of the joints
What do Non-biological target immune cells, usually by unknown mechanism
DMARD's do?
What do Biological highly specific and target a specific pathway of the
DMARD's do? immune system
may exert immunosuppressive effects by inhibiting
replication and function of T and possible B
Methotrexate MOA?
lymphocytes. It interrupts the process that causes
inflammation to prevent damage joints.
https://quizlet.com/1094288435/n191-dmards-exam-with-correct-answers-flash-cards/?new 1/6
, breastfeeding
- pregnancy
- alcoholism - for people who have alcohol disorders
too
Methotrexate
- alcoholic and chronic liver disease
Contraindications?
- laboratory evidence or overt immunodeficiency
syndromes
- preexisting blood dyscrasias (bone marrow
hypoplasia, leukopenia etc..)
What do monitor for with Monitor patient for hypersensitivity reaction to drug
Methotrexate? as anaphylaxis have occurred with drug use.
onset of ischemic optic neuropathy, retinal cotton-
wool spots, and orbital non-Hodgkin's lymphoma
(Dammacco et al., 2022)
Reduces risk of heart disease due to reduction in
arterial inflammation
Methotrexate/DMARD's
Photosensitivity
Effects on the Body?
Dyspnea, pneumonia
- have immunosuppressive effects that increase the
risk of bacterial and opportunistic lung infection
(Lake, n.d.)
Pain, bloating, constipation, and diarrhea
The immune system is mildly suppressed
Non-Biologic DMARD's
Therefore, decreases s/s of rheumatoid arthritis &
Therapeutic Action?
lupus
Binds to TNF (tumor necrosis factor)
Reduced TNF level found in the synovial fluid
Biologic DMARDs (TNF improves s/s
antagonists) Therapeutic Also, prevents further structural damage caused by
Action? rheumatoid arthritis
Decreases levels of C-reactive protein
- In result, will decrease s/s of inflammation
https://quizlet.com/1094288435/n191-dmards-exam-with-correct-answers-flash-cards/?new 2/6
Save
Terms in this set (17)
are a group of medications commonly used in people
with
rheumatoid arthritis
What are DMARD's? also used in psoriatic arthritis, ankylosing spondylitis,
and systemic lupus erythematosus
For autoimmune things, body attacks itself so the
drugs suppress immune system
decrease pain and inflammation
What do DMARD's work reduce or prevent joint damage - slows joint
to do? degradation
preserve the structure and function of the joints
What do Non-biological target immune cells, usually by unknown mechanism
DMARD's do?
What do Biological highly specific and target a specific pathway of the
DMARD's do? immune system
may exert immunosuppressive effects by inhibiting
replication and function of T and possible B
Methotrexate MOA?
lymphocytes. It interrupts the process that causes
inflammation to prevent damage joints.
https://quizlet.com/1094288435/n191-dmards-exam-with-correct-answers-flash-cards/?new 1/6
, breastfeeding
- pregnancy
- alcoholism - for people who have alcohol disorders
too
Methotrexate
- alcoholic and chronic liver disease
Contraindications?
- laboratory evidence or overt immunodeficiency
syndromes
- preexisting blood dyscrasias (bone marrow
hypoplasia, leukopenia etc..)
What do monitor for with Monitor patient for hypersensitivity reaction to drug
Methotrexate? as anaphylaxis have occurred with drug use.
onset of ischemic optic neuropathy, retinal cotton-
wool spots, and orbital non-Hodgkin's lymphoma
(Dammacco et al., 2022)
Reduces risk of heart disease due to reduction in
arterial inflammation
Methotrexate/DMARD's
Photosensitivity
Effects on the Body?
Dyspnea, pneumonia
- have immunosuppressive effects that increase the
risk of bacterial and opportunistic lung infection
(Lake, n.d.)
Pain, bloating, constipation, and diarrhea
The immune system is mildly suppressed
Non-Biologic DMARD's
Therefore, decreases s/s of rheumatoid arthritis &
Therapeutic Action?
lupus
Binds to TNF (tumor necrosis factor)
Reduced TNF level found in the synovial fluid
Biologic DMARDs (TNF improves s/s
antagonists) Therapeutic Also, prevents further structural damage caused by
Action? rheumatoid arthritis
Decreases levels of C-reactive protein
- In result, will decrease s/s of inflammation
https://quizlet.com/1094288435/n191-dmards-exam-with-correct-answers-flash-cards/?new 2/6
