Molecular Signal Transduction

Molecular Signal Transduction



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BY: Abraham D (Msc)

, Outlines

• Introduction to cell signaling

• Key elements in signal transduction

• Type of signaling based on distance

• Steps of signal transduction

• Signaling molecules

• Signal transduction through various receptors

• Promising drug targets




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, Introduction to cell signaling

• Cells regulate its intracellular and extracellular environment, processes the

information it gathers, and responds accordingly.

• Cell signaling is the ability of a cell to receive, process, and transmit signals

with its environment and with itself.

 It is a fundamental property of all cells in every living organism

• Cell signaling is a controlled dynamic process

• Have mechanisms for responding to physical and chemical changes in their

environment.

• This mechanism helps cells to have a communication with other cells
3

, Cont…




• Reception of the signals depends on protein at the cell surface

• Most are receptors

• The binding activates the receptor, which in turn activates one
or more intracellular signaling pathways or systems

Then distribute it to the appropriate intracellular targets


Effector proteins