Pharmacology Mastery Challenge: 150-
Question Ultimate Mixed Review from the
500-Item Mega Pack
(Answers And Rationale)
2025/2026
1. Which drug class is primarily used to treat hypertension by
blocking angiotensin II receptors?
A. ACE inhibitors
B. Beta blockers
C. Calcium channel blockers
D. Angiotensin II receptor blockers
Answer: D. Angiotensin II receptor blockers
Rationale: ARBs block the binding of angiotensin II to its
receptor, causing vasodilation and reduced blood pressure.
2. A common side effect of opioid analgesics is:
A. Hypertension
B. Diarrhea
C. Constipation
D. Polyuria
Answer: C. Constipation
Rationale: Opioids slow gastrointestinal motility, leading to
constipation.
3. Which antibiotic class inhibits bacterial protein synthesis at the
30S ribosomal subunit?
, A. Macrolides
B. Tetracyclines
C. Fluoroquinolones
D. Sulfonamides
Answer: B. Tetracyclines
Rationale: Tetracyclines bind to the 30S ribosomal subunit to
inhibit protein synthesis.
4. Warfarin is primarily used for which purpose?
A. Pain relief
B. Infection control
C. Blood thinning
D. Acid reflux
Answer: C. Blood thinning
Rationale: Warfarin is an anticoagulant that prevents clot
formation.
5. Which medication is considered a loop diuretic?
A. Hydrochlorothiazide
B. Furosemide
C. Spironolactone
D. Acetazolamide
Answer: B. Furosemide
Rationale: Furosemide acts on the loop of Henle to promote
diuresis.
6. The primary mechanism of beta blockers is to:
A. Increase heart rate
B. Decrease heart rate
C. Increase blood sugar
D. Dilate pupils
, Answer: B. Decrease heart rate
Rationale: Beta blockers reduce heart rate and cardiac workload.
7. Which drug is used as an antidote for opioid overdose?
A. Flumazenil
B. Naloxone
C. Atropine
D. Protamine
Answer: B. Naloxone
Rationale: Naloxone competitively antagonizes opioid receptors.
8. A major adverse effect of aminoglycosides is:
A. Hepatotoxicity
B. Ototoxicity
C. Photosensitivity
D. Constipation
Answer: B. Ototoxicity
Rationale: Aminoglycosides can damage the inner ear, causing
hearing loss.
9. Which medication is used to treat hypothyroidism?
A. Methimazole
B. Propylthiouracil
C. Levothyroxine
D. Propranolol
Answer: C. Levothyroxine
Rationale: Levothyroxine is synthetic thyroid hormone
replacement.
10. What is the therapeutic use of albuterol?
A. Treat hypertension
B. Treat asthma
C. Control diabetes
, D. Treat infections
Answer: B. Treat asthma
Rationale: Albuterol is a short-acting beta-2 agonist that
bronchodilates.
11. Which insulin is considered rapid-acting?
A. NPH
B. Regular insulin
C. Insulin lispro
D. Insulin glargine
Answer: C. Insulin lispro
Rationale: Lispro is a rapid-acting insulin used for mealtime
glucose control.
12. Metformin primarily decreases:
A. Intestinal fat absorption
B. Hepatic glucose production
C. Renal glucose excretion
D. Insulin secretion
Answer: B. Hepatic glucose production
Rationale: Metformin reduces glucose output from the liver.
13. Which drug class is most associated with causing cough?
A. ARBs
B. ACE inhibitors
C. Diuretics
D. Beta blockers
Answer: B. ACE inhibitors
Rationale: ACE inhibitors increase bradykinin, leading to dry
cough.
14. Which electrolyte imbalance is most associated with loop
diuretics?
Question Ultimate Mixed Review from the
500-Item Mega Pack
(Answers And Rationale)
2025/2026
1. Which drug class is primarily used to treat hypertension by
blocking angiotensin II receptors?
A. ACE inhibitors
B. Beta blockers
C. Calcium channel blockers
D. Angiotensin II receptor blockers
Answer: D. Angiotensin II receptor blockers
Rationale: ARBs block the binding of angiotensin II to its
receptor, causing vasodilation and reduced blood pressure.
2. A common side effect of opioid analgesics is:
A. Hypertension
B. Diarrhea
C. Constipation
D. Polyuria
Answer: C. Constipation
Rationale: Opioids slow gastrointestinal motility, leading to
constipation.
3. Which antibiotic class inhibits bacterial protein synthesis at the
30S ribosomal subunit?
, A. Macrolides
B. Tetracyclines
C. Fluoroquinolones
D. Sulfonamides
Answer: B. Tetracyclines
Rationale: Tetracyclines bind to the 30S ribosomal subunit to
inhibit protein synthesis.
4. Warfarin is primarily used for which purpose?
A. Pain relief
B. Infection control
C. Blood thinning
D. Acid reflux
Answer: C. Blood thinning
Rationale: Warfarin is an anticoagulant that prevents clot
formation.
5. Which medication is considered a loop diuretic?
A. Hydrochlorothiazide
B. Furosemide
C. Spironolactone
D. Acetazolamide
Answer: B. Furosemide
Rationale: Furosemide acts on the loop of Henle to promote
diuresis.
6. The primary mechanism of beta blockers is to:
A. Increase heart rate
B. Decrease heart rate
C. Increase blood sugar
D. Dilate pupils
, Answer: B. Decrease heart rate
Rationale: Beta blockers reduce heart rate and cardiac workload.
7. Which drug is used as an antidote for opioid overdose?
A. Flumazenil
B. Naloxone
C. Atropine
D. Protamine
Answer: B. Naloxone
Rationale: Naloxone competitively antagonizes opioid receptors.
8. A major adverse effect of aminoglycosides is:
A. Hepatotoxicity
B. Ototoxicity
C. Photosensitivity
D. Constipation
Answer: B. Ototoxicity
Rationale: Aminoglycosides can damage the inner ear, causing
hearing loss.
9. Which medication is used to treat hypothyroidism?
A. Methimazole
B. Propylthiouracil
C. Levothyroxine
D. Propranolol
Answer: C. Levothyroxine
Rationale: Levothyroxine is synthetic thyroid hormone
replacement.
10. What is the therapeutic use of albuterol?
A. Treat hypertension
B. Treat asthma
C. Control diabetes
, D. Treat infections
Answer: B. Treat asthma
Rationale: Albuterol is a short-acting beta-2 agonist that
bronchodilates.
11. Which insulin is considered rapid-acting?
A. NPH
B. Regular insulin
C. Insulin lispro
D. Insulin glargine
Answer: C. Insulin lispro
Rationale: Lispro is a rapid-acting insulin used for mealtime
glucose control.
12. Metformin primarily decreases:
A. Intestinal fat absorption
B. Hepatic glucose production
C. Renal glucose excretion
D. Insulin secretion
Answer: B. Hepatic glucose production
Rationale: Metformin reduces glucose output from the liver.
13. Which drug class is most associated with causing cough?
A. ARBs
B. ACE inhibitors
C. Diuretics
D. Beta blockers
Answer: B. ACE inhibitors
Rationale: ACE inhibitors increase bradykinin, leading to dry
cough.
14. Which electrolyte imbalance is most associated with loop
diuretics?
