Page 1 of 40
NURS 5315 MSK EXAM 1 NEWEST 2025 ACTUAL
EXAM| ADVANCED PATHOPHYSIOLOGY EXAM|
COMPLETE QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS) ALREADY GRADED
A+| NEW!!
Which bone cell is primarily responsible for bone resorption?
a. Osteoblast
b. Osteocyte
c. Osteoclast
d. Chondrocyte .....ANSWER..... c. Osteoclast
What signaling molecule secreted by osteocytes inhibits
osteoblast activity?
a. RANK
b. Sclerostin
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c. Cathepsin K
d. Osteocalcin .....ANSWER..... b. Sclerostin
Which of the following is a biochemical marker of osteoblast
activity?
a. Tartrate-resistant acid phosphatase (TRAP)
b. Osteocalcin
c. Cathepsin K
d. Matrix metalloproteinases (MMPs)
.....ANSWER..... b. Osteocalcin
What is the primary function of osteocytes within the bone
matrix?
a. Synthesizing osteoid
b. Resorbing bone tissue
c. Maintaining bone homeostasis
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d. Initiating fracture repair
.....ANSWER..... c. Maintaining bone homeostasis
Which enzyme is secreted by osteoclasts to degrade the
collagen matrix?
a. Alkaline phosphatase
b. Cathepsin K
c. Acid phosphatase
d. Osteopontin .....ANSWER..... b. Cathepsin K
True or False: Osteoblasts originate from hematopoietic stem
cells. .....ANSWER..... False (Osteoblasts originate from
mesenchymal stem cells.)
True or False: The RANKL/OPG ratio is critical in regulating
osteoclast activity. .....ANSWER..... True
, Page 4 of 40
True or False:Sclerostin production by osteocytes is increased in
response to mechanical loading. .....ANSWER..... False (Sclerostin
production decreases in response to mechanical loading.)
True or False: Vitamin D deficiency leads to impaired collagen
synthesis in the bone matrix. .....ANSWER..... False (Vitamin D
deficiency impairs calcium absorption, while Vitamin C deficiency
affects collagen synthesis.)
True or False: Osteocytes communicate with neighboring cells
through dendritic processes in canaliculi. .....ANSWER..... True
What is the role of the RANK/RANKL/OPG system in bone
remodeling?
a. RANK/RANKL interaction promotes osteoblast differentiation
and activity, leading to bone formation.
b. OPG binds to RANKL, preventing its interaction with RANK,
thereby inhibiting osteoclast activity
NURS 5315 MSK EXAM 1 NEWEST 2025 ACTUAL
EXAM| ADVANCED PATHOPHYSIOLOGY EXAM|
COMPLETE QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS) ALREADY GRADED
A+| NEW!!
Which bone cell is primarily responsible for bone resorption?
a. Osteoblast
b. Osteocyte
c. Osteoclast
d. Chondrocyte .....ANSWER..... c. Osteoclast
What signaling molecule secreted by osteocytes inhibits
osteoblast activity?
a. RANK
b. Sclerostin
,Page 2 of 40
c. Cathepsin K
d. Osteocalcin .....ANSWER..... b. Sclerostin
Which of the following is a biochemical marker of osteoblast
activity?
a. Tartrate-resistant acid phosphatase (TRAP)
b. Osteocalcin
c. Cathepsin K
d. Matrix metalloproteinases (MMPs)
.....ANSWER..... b. Osteocalcin
What is the primary function of osteocytes within the bone
matrix?
a. Synthesizing osteoid
b. Resorbing bone tissue
c. Maintaining bone homeostasis
,Page 3 of 40
d. Initiating fracture repair
.....ANSWER..... c. Maintaining bone homeostasis
Which enzyme is secreted by osteoclasts to degrade the
collagen matrix?
a. Alkaline phosphatase
b. Cathepsin K
c. Acid phosphatase
d. Osteopontin .....ANSWER..... b. Cathepsin K
True or False: Osteoblasts originate from hematopoietic stem
cells. .....ANSWER..... False (Osteoblasts originate from
mesenchymal stem cells.)
True or False: The RANKL/OPG ratio is critical in regulating
osteoclast activity. .....ANSWER..... True
, Page 4 of 40
True or False:Sclerostin production by osteocytes is increased in
response to mechanical loading. .....ANSWER..... False (Sclerostin
production decreases in response to mechanical loading.)
True or False: Vitamin D deficiency leads to impaired collagen
synthesis in the bone matrix. .....ANSWER..... False (Vitamin D
deficiency impairs calcium absorption, while Vitamin C deficiency
affects collagen synthesis.)
True or False: Osteocytes communicate with neighboring cells
through dendritic processes in canaliculi. .....ANSWER..... True
What is the role of the RANK/RANKL/OPG system in bone
remodeling?
a. RANK/RANKL interaction promotes osteoblast differentiation
and activity, leading to bone formation.
b. OPG binds to RANKL, preventing its interaction with RANK,
thereby inhibiting osteoclast activity
