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What are the 3 layers of human defense? What happens during
each? .....ANSWER..... Physical- protect against damage and
infection are composed of tightly associated epithelial cells
including those of the skin and of the membranous sheets lining
the gastrointestinal, genitourinary, and respiratory tracts.
Mechanical- "washing" the surfaces (sloughing off of dead skin,
vomiting, urination, coughing). Biochemical barriers- secrets
substances meant to trap of destroy microorganisms. (Mucus,
sweat, saliva, tears, sebaceous glands, and earwax).
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What is the second line of defense and the process?
.....ANSWER..... Inflammatory response- rapid and nonspecific,
protective response to cellular injury from any cause. It can occur
only in vascularized tissue.
How do acute and chronic inflammation differ? .....ANSWER.....
Acute- Short duration, 8-10 days from onset to healing. The three
systemic changes associated with the acute inflammatory
response are fever, leukocytosis, and plasma protein synthesis.
Chronic inflammation- can be a continuation of acute
inflammation that last 2 weeks or longer. It can also occur as a
distinct process without much preceding acute inflammation.
What are the phases of wound healing and the process that
takes place during each? .....ANSWER..... Phase 1- Inflammation-
includes coagulation and the infiltration of cells that participate
in wound healing, including platelets, neutrophils, and
macrophages. Phase 2- Proliferation and New Tissue Formation
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(Reconstruction)- wound begins to heal. This stage begins 3-4
days after injury and continues for as long as 2 weeks. Phase 3-
Remodeling and Maturation- phase for recovering normal tissue
structure that can persist for years
How does the inflammatory response differ in neonates?
.....ANSWER..... Neonates often have transiently depressed
inflammatory function, particularly neutrophil chemotaxis and
alternative complement activity.
How and why does aging affect innate immunity? .....ANSWER.....
Aging alters the tissue microenvironment and macrophage
function with changes in wound healing neoangiogenesis and
fibrosis.
What is the third line of defense and the process that takes
place? .....ANSWER..... Adaptive immunity (immune response or
immunity)- the third line of defense in the human body. Consists
of lymphocytes and serum proteins called antibodies. -