Page 1 of 91
UWorld Self-Assessments 2 / Step 2 CK NBME Q & A;
100% Correct (2025)
Mitral stenosis .....ANSWER.....Most commonly caused by
rheumatic fever.
Diastolic thrill palpable over cardiac apex.
Low-pitched diastolic murmur best heard over the apex.
Rupture of high pressure bronchial veins may lead to hemoptysis.
Infective endocarditis .....ANSWER.....Causes mitral/tricuspid
regurgitation
Peutz-Jegher's syndrome .....ANSWER.....AD serine/threonine
kinase 11 mutation on chromosome 19.
Hyperpigmented buccal mucosa, lips, hands, genitalia and
hamartomatous polyps in GI tract.
Liposarcoma .....ANSWER.....Most common soft tissue tumor.
Numerous lipoblasts producing non-membrane-bound
,Page 2 of 91
cytoplasmic lipid. Causes nuclear indentations and scalloping of
nuclear membrane.
Note that lipomas, in contrast, consist of mature fat cells without
pleomorphism.
Pemphigus vulgaris .....ANSWER.....IgG anti-desmoglein
antibodies in the epidermis. Desmosomal junctions mediate
adherence of epidermal keratinocytes to one another.
Bullous pemphigoid .....ANSWER.....IgG anti-hemidesmosome
antibodies in the basement membrane.
Dermatitis herpetiformis .....ANSWER.....IgA deposition in the
papillary dermis
Epidermolysis bullosa acquisita .....ANSWER.....Anti-type VII
collagen antibodies in the dermoepidermal junction.
,Page 3 of 91
Neonatal RDS .....ANSWER.....Reduced compliance (increased
lung recoil) due to decreased surfactant. The majority of lung
recoil force may be attributed to alveolar surface tension.
Horner syndrome characteristic
-What is being compressed .....ANSWER.....MAP: Miosis,
Anhydrosis, Ptosis. Compression of the superior cervical ganglion
(symp nerves)
Apical bronchogenic carcinoma.. think .....ANSWER.....pancost
tumor--> Horners
Pancost tumor compresses what and causes what
.....ANSWER.....brachial plexus
Causing horners
What is the best way to achieve fertility in patients with Turner
syndrome? .....ANSWER.....IVF. Most patients are infertile
secondary to ovarian failure and premature follicular atresia.
, Page 4 of 91
Thus, viable ova must be obtained from an external source for
pregnancy to occur.
Lining of Meckel diverticula .....ANSWER.....Ileal mucosa or
ectopic gastric, pancreatic, jejunal, or colonic tissue.
What type of murmur is characteristic in hypertrophic
cardiomyopathy? .....ANSWER.....Systolic crescendo-decrescendo
murmur heard between the apex and left sternal border
radiation to the suprasternal notch. Murmur becomes quieter with
increases in preload or afterload and louder with decreases in
preload or afterload.
What is the difference between DNA polymerase I and DNA
polymerase III? .....ANSWER.....DNA polymerase III synthesizes
DNA in the presence of RNA primers. Primase is necessary for the
proper functioning of DNA polymerase III. In contrast, DNA
polymerase I is responsible for the removal of RNA primers and
synthesis of new DNA in their place. Defects in DNA polymerase I
UWorld Self-Assessments 2 / Step 2 CK NBME Q & A;
100% Correct (2025)
Mitral stenosis .....ANSWER.....Most commonly caused by
rheumatic fever.
Diastolic thrill palpable over cardiac apex.
Low-pitched diastolic murmur best heard over the apex.
Rupture of high pressure bronchial veins may lead to hemoptysis.
Infective endocarditis .....ANSWER.....Causes mitral/tricuspid
regurgitation
Peutz-Jegher's syndrome .....ANSWER.....AD serine/threonine
kinase 11 mutation on chromosome 19.
Hyperpigmented buccal mucosa, lips, hands, genitalia and
hamartomatous polyps in GI tract.
Liposarcoma .....ANSWER.....Most common soft tissue tumor.
Numerous lipoblasts producing non-membrane-bound
,Page 2 of 91
cytoplasmic lipid. Causes nuclear indentations and scalloping of
nuclear membrane.
Note that lipomas, in contrast, consist of mature fat cells without
pleomorphism.
Pemphigus vulgaris .....ANSWER.....IgG anti-desmoglein
antibodies in the epidermis. Desmosomal junctions mediate
adherence of epidermal keratinocytes to one another.
Bullous pemphigoid .....ANSWER.....IgG anti-hemidesmosome
antibodies in the basement membrane.
Dermatitis herpetiformis .....ANSWER.....IgA deposition in the
papillary dermis
Epidermolysis bullosa acquisita .....ANSWER.....Anti-type VII
collagen antibodies in the dermoepidermal junction.
,Page 3 of 91
Neonatal RDS .....ANSWER.....Reduced compliance (increased
lung recoil) due to decreased surfactant. The majority of lung
recoil force may be attributed to alveolar surface tension.
Horner syndrome characteristic
-What is being compressed .....ANSWER.....MAP: Miosis,
Anhydrosis, Ptosis. Compression of the superior cervical ganglion
(symp nerves)
Apical bronchogenic carcinoma.. think .....ANSWER.....pancost
tumor--> Horners
Pancost tumor compresses what and causes what
.....ANSWER.....brachial plexus
Causing horners
What is the best way to achieve fertility in patients with Turner
syndrome? .....ANSWER.....IVF. Most patients are infertile
secondary to ovarian failure and premature follicular atresia.
, Page 4 of 91
Thus, viable ova must be obtained from an external source for
pregnancy to occur.
Lining of Meckel diverticula .....ANSWER.....Ileal mucosa or
ectopic gastric, pancreatic, jejunal, or colonic tissue.
What type of murmur is characteristic in hypertrophic
cardiomyopathy? .....ANSWER.....Systolic crescendo-decrescendo
murmur heard between the apex and left sternal border
radiation to the suprasternal notch. Murmur becomes quieter with
increases in preload or afterload and louder with decreases in
preload or afterload.
What is the difference between DNA polymerase I and DNA
polymerase III? .....ANSWER.....DNA polymerase III synthesizes
DNA in the presence of RNA primers. Primase is necessary for the
proper functioning of DNA polymerase III. In contrast, DNA
polymerase I is responsible for the removal of RNA primers and
synthesis of new DNA in their place. Defects in DNA polymerase I
