Toxicology Exam #1
1. In a probit graph, the median of the dose-response distribution is set to
five and each unit above or below the median is equivalent to one standard
deviation from the median: F
2. A chemical is tested in an acute exposure study and no effects are seen, even
at high doses (>5 g/kg). If the EPA accepts this data as being valid, regulators
may not require additional tests to be preformed on the compound.: T
3. In order to best control for the stress of direct (parenteral) exposure of
terrestrial animals in a study, the control animals are not dosed at all. This
allows the researcher to determine what part of the results is due to the stress
of the exposure method and what is due to the toxin that was administered.: F
1/3
, 4. If a frequency dose response curve is bimodal, this might suggest that there
are actually two genetic sub-populations in the organisms that were used in
the study.: T
5. For many compounds, pH does not affect whether the compound is ionized
or not.: T
6. For particulate material, the smaller the particle is the more likely it is that it
will be retained in the alveoli.: F
7. If an inhaled toxin has low solubility in blood it will tend to be ventilation
limited. The amount of the toxin absorbed will be limited by the rate at which
the individual is breathing.: F
8. Because of the pH of the fetus plasma is slightly different than that of the
2/3
1. In a probit graph, the median of the dose-response distribution is set to
five and each unit above or below the median is equivalent to one standard
deviation from the median: F
2. A chemical is tested in an acute exposure study and no effects are seen, even
at high doses (>5 g/kg). If the EPA accepts this data as being valid, regulators
may not require additional tests to be preformed on the compound.: T
3. In order to best control for the stress of direct (parenteral) exposure of
terrestrial animals in a study, the control animals are not dosed at all. This
allows the researcher to determine what part of the results is due to the stress
of the exposure method and what is due to the toxin that was administered.: F
1/3
, 4. If a frequency dose response curve is bimodal, this might suggest that there
are actually two genetic sub-populations in the organisms that were used in
the study.: T
5. For many compounds, pH does not affect whether the compound is ionized
or not.: T
6. For particulate material, the smaller the particle is the more likely it is that it
will be retained in the alveoli.: F
7. If an inhaled toxin has low solubility in blood it will tend to be ventilation
limited. The amount of the toxin absorbed will be limited by the rate at which
the individual is breathing.: F
8. Because of the pH of the fetus plasma is slightly different than that of the
2/3
