RW MRCP Part 1 – Gastroenterology Exam Questions and answers

RW MRCP Part 1 – Gastroenterology Exam Questions and answers Suspected C.diff infection nursing Side room Hand hygiene using soap and water Single-use gloves and aprons. Clostridioides difficile Gram positive rod - produces exotoxin --> intestinal damage leading to pseudomembranous colitis. Often when normal gut flora weakened by broad spec Abx e.g clindamycin + cephalosporins, PPis Clostridioides difficile pathophysiology Anaerobic gram-positive, spore-forming, toxin-producing bacillus Transmission: via the faecal-oral route by ingestion of spores releases two exotoxins (toxin A and toxin B) that act on intestinal epithelial cells and inflammatory cells resulting in colitis C.diff infection features Diarrhoea Abdominal pain Raised white blood cell count (WCC)