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Emergency Nursing Orientation 2.0 – 30+ Solved Questions | Substance Abuse, Toxicology, Withdrawal, ED Interventions | 2025/2026

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This document includes 30+ fully solved and graded questions with verified answers from the Emergency Nursing Orientation 2.0: Substance Abuse exam for the 2025/2026 academic year. Developed for nurses in emergency and acute care settings, this material offers an in-depth review of clinical protocols, toxicology knowledge, and patient care strategies related to substance abuse and overdose situations. The quiz addresses a broad range of substance-related emergencies and patient scenarios, including: Commonly abused substances (e.g., heroin, alcohol, marijuana, GHB, ecstasy, inhalants) Acute complications and toxidromes (e.g., respiratory depression, tachycardia, myocardial ischemia, hallucinations, agitation) ED priorities in unknown substance ingestion Management of withdrawal syndromes and appropriate pharmacological interventions Substance classification (depressants, stimulants, hallucinogens, designer drugs) Age-specific and high-risk population considerations This exam resource is ideal for: Emergency department nurses and trauma unit staff New nurse hires undergoing orientation in acute or behavioral health care Nursing students in critical care or mental health rotations Healthcare professionals preparing for hospital-based certification or continuing education Each question is clearly answered and designed to enhance practical readiness and reinforce core nursing competencies in substance abuse recognition, stabilization, and management. Keywords: emergency nursing orientation, substance abuse exam, ED protocols, overdose management, GHB, heroin withdrawal, stimulant intoxication, nursing toxicology, Narcan administration, designer drugs, inhalant effects, patient safety, Lorazepam for withdrawal, behavioral health emergencies, alcohol dependence care

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Emergency Nursing Orientation 2.0:
Substance Abuse 2025/2026 Exam
Questions and Answers | A+ Score
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In substance abuse, which chemical is primarily responsible for alterations

in neurotransmission? - 🧠 ANSWER ✔✔Dopamine


What is the most commonly used illegal substance in the United States? - 🧠

ANSWER ✔✔Marijuana


Which cardiovascular disorder is most commonly associated with cocaine

abuse? - 🧠 ANSWER ✔✔Acute coronary syndrome (ACS)


Which intervention is most important in managing a patient who has

ingested or abused an unknown substance? - 🧠 ANSWER ✔✔Establish

and maintain an airway.

, Which complication is associated with heroin abuse? - 🧠 ANSWER

✔✔bacterial endocarditis


Which intoxicant is most likely to be abused by a preteen? - 🧠 ANSWER

✔✔Inhalants


Which abused substance belongs to the depressant drug class? - 🧠

ANSWER ✔✔Alcohol


You should expect to administer naloxone (Narcan) to patients who have

taken which substance? - 🧠 ANSWER ✔✔Heroin


After partying at a nightclub, a college student is brought to the ED by his

roommates. The patient states he's "high." He has tachycardia,

hypertension, and hyperthermia. Based on these findings, intoxication with

which substance is most likely? - 🧠 ANSWER ✔✔Ecstasy


A patient presents to the ED with hallucinations and fresh track marks on

his forearm. Which drug should you suspect of being injected by the

patient? - 🧠 ANSWER ✔✔Phencyclidine (PCP


Which of the following substances can cause feelings of paranoia - 🧠

ANSWER ✔✔Psilocybin
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