COMPLETE QUESTIONS WITH DETAILED VERIFIED ANSWERS
(100% CORRECT ANSWERS) /ALREADY GRADED A+
1. Cartilage is made of ✓ collagen and protein
2. Joint Cartilage is made of ✓ extracellular matrix and
chondrocytes
3. Extracellular matrix contains ✓ type 2, 4, and 6 collagens as well
primarily as aggrecan proteoglycans
4. Type 2 collagen is responsible for ✓ protecting the ends of bone within a
joint
5. Aggrecan proteoglycan is mainly ✓ retaining water molecules, allowing
responsible for resistance to affects of strenuous
use of the joint
6. Chondrocytes within joint cartilage ✓ the strength and resistance to
is responsible for loading
7. What is the pathophysiology of ✓ when cartilage becomes damaged it
osteoarthritis? starts to lose elasticity, making it
more susceptible to injury. With
increasing stress and wear the
, bone starts to become affected
causing thickening of bone and
formation of bone spurs and
osteophytes. Abnormal bone
formations can break loose with
cartilage fragments and float within
joint space. Debris cause synovium
to mount and inflammatory
response to break down
cartilaginous debris.
8. What does the inflammatory ✓ the breakdown of remaining healthy
response during degeneration of cartilage, leading to further
cartilage increase? degeneration
9. Osteoarthritis symptoms: ✓ pain that is exacerbated with activity
and better with rest (early dz),
stiffness, swelling, pain and
stiffness worse in the morning (no
more than 30 min), pain worse with
prolong inactivity or weather
changes
10. Hip osteoarthritis symptoms: ✓ pain in low back and groin, limping
and knee pain from compensation
11. Knee osteoarthritis symptoms: ✓ locking, cracking, grinding, "give